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Pellet type sustained-release tablet and preparation method thereof

A sustained-release tablet and pellet-type technology, which is applied in pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc. cracks etc.

Inactive Publication Date: 2017-01-11
HYBIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the two drugs are currently prepared into pellet-type sustained-release tablets, which has the problems of easy rupture of the coating film, low release rate, and inability to synchronize sustained-release

Method used

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  • Pellet type sustained-release tablet and preparation method thereof
  • Pellet type sustained-release tablet and preparation method thereof
  • Pellet type sustained-release tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] The preparation of embodiment 1 pellet type sustained-release tablet

[0082]

[0083]

[0084] Preparation method: dissolve metoprolol tartrate and PVA in purified water to prepare a drug solution, and spray the drug solution on SiO 2 The surface of the pellet core is prepared as a drug-loaded pellet core; then the prescribed amount of Eudragit NE 30D and PEG3350 are formulated into a 15% solution, and the drug-loaded pellet core is coated to obtain the metoprolol tartrate sustained-release coated pellets.

[0085] Felodipine is micronized to obtain a powder smaller than 50 μm, which is dispersed in an aqueous solution of sodium lauryl sulfate and used as a binder for fluidized bed top spray granulation. The binder is sprayed on the surface of the mixture of HPMC K4M, PEG6000, microcrystalline cellulose PH101 and corn starch, and top-spray granulation is carried out to obtain felodipine slow-release granules.

[0086] Mix metoprolol tartrate sustained-release co...

Embodiment 2

[0091] The preparation of embodiment 2 micropill type sustained-release tablets

[0092]

[0093] The preparation method is the same as in Example 1.

Embodiment 3

[0094] The preparation of embodiment 3 micropill type sustained-release tablets

[0095]

[0096]

[0097] The preparation method is the same as in Example 1.

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Abstract

The invention relates to the field of medicinal preparation, and especially relates to a pellet type sustained-release tablet and a preparation method thereof. The pellet type sustained-release tablet comprises metoprolol salts and felodipine. The preparation method can reduce the happening rate of rupture of the coating membrane of metroprolol succinate sustained-release pellets during the tablet compressing process; thus the release degrees of metoprolol are very similar before and after the tablet compressing; and compared with the preparations on the market, the release degree of metoprolol can be well repeated. The pellet type sustained-release tablet can simultaneously release metoprolol and felodipine for 24 hours in a sustained-release mode.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a pellet-shaped sustained-release tablet and a preparation method thereof. Background technique [0002] Hypertension is a systemic disease characterized by elevated arterial pressure, which may be accompanied by functional or organic changes in the heart, blood vessels, brain, kidneys and other organs. It has primary hypertension and secondary hypertension points. Hypertension is the most common chronic disease and the most important risk factor for cardiovascular and cerebrovascular diseases. Stroke, myocardial infarction, heart failure and chronic kidney disease are its main complications. [0003] Metoprolol, belongs to class 2A, that is, β1-receptor blockers without partial agonistic activity (cardioselective β-receptor blockers). It has selective blocking effect on β1-receptor, no PAA (partial agonistic activity), no membrane stabilizing effect. Its blocking ef...

Claims

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Application Information

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IPC IPC(8): A61K9/36A61K9/32A61K31/4422A61K47/32A61K47/38A61K47/36A61K47/44A61P9/12A61K31/138
Inventor 左灵静刘慧陶安进马亚平袁建成
Owner HYBIO PHARMA
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