Method for preparing implantable bone grafts by de-organification and 3D printing of animal bones

A 3D printing and animal bone technology, applied in bone implants, medical science, prostheses, etc., can solve the problems of not being able to adapt to the shape of the patient's bone graft area, and not being able to fully fill the defect area, etc., and achieve a good market prospect , good bone formation, simple and easy method

Inactive Publication Date: 2017-01-25
THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The currently used xenografts are mostly made into small pieces or strips, which often cannot well adapt to the shape of the bone graft area required by the patient in clinical use, and cannot fully fill the defect area

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: This method uses animal bone deorganization 3D printing to prepare an implantable bone graft, the specific content is as follows:

[0021] (1) Take fresh bovine bone to remove soft tissue, wash it with normal saline, place it at 1000°C for 4 hours, and then crush it to obtain bone particles with a particle size of less than 1mm;

[0022] (2) Heat polylactic acid to 70°C to form a paste, and then mix it with bone particles at a mass ratio of 1:3;

[0023] (3) Three-dimensional scanning is performed on the part of the patient to be implanted before the operation, and the three-dimensional model of the bone graft is drawn by using the drawing software, and the drawn structure is printed by the 3D printer, and the implantable bone graft is obtained after cooling.

Embodiment 2

[0024] Example 2: This method uses animal bone deorganization 3D printing to prepare implantable bone grafts, the specific content is as follows:

[0025] (1) Take fresh sheep bone to remove soft tissue, wash it with normal saline, place it at 1100°C for 3 hours, and then pulverize it to obtain bone particles with a particle size of less than 1mm;

[0026] (2) Heat chitosan and fibrin glue to 70°C to form a paste, and then the adhesive (chitosan:fibrin glue = mass ratio 1:1) and bone particles in a mass ratio of 1:5 to mix;

[0027] (3) By performing three-dimensional scanning on the part of the patient to be implanted before the operation, the three-dimensional model of the bone graft is drawn by using the drawing software, and the drawn structure is printed by a 3D printer, and the implantable bone graft is obtained after cooling.

Embodiment 3

[0028] Example 3: This method uses animal bone deorganization 3D printing to prepare implantable bone grafts, the specific content is as follows:

[0029] (1) Fresh pork bones were taken to remove soft tissue, washed with normal saline, placed at 1000°C for 4 hours, and then crushed to obtain bone particles with a particle size of less than 1 mm;

[0030] (2) Heat chitosan to 60°C to form a paste, and then mix it with bone particles at a mass ratio of 1:4;

[0031] (3) Three-dimensional scanning is performed on the part of the patient to be implanted before the operation, and the three-dimensional model of the bone graft is drawn by drawing software, and the above-mentioned material is drawn to form a filament. After cooling, the drawn structure is drawn by a 3D printer. Printed, cooled to create an implantable bone graft.

[0032] After using this product: 1. It can further increase the probability of bone fusion; 2. Through the growth of bone tissue, this product can comple...

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PUM

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Abstract

The invention discloses a method for preparing implantable bone grafts by de-organification and 3D printing of animal bones. The method comprises the steps of de-organification, adhesive injection and reinforcement as well as 3D molding printing. Besides, the method is simple and easy, suitable for orthopedic bone defect repair, bone tumor, spine graft fusion surgery and other areas requiring bone graft materials. Also, the bone graft is characterized by wide range of raw materials, low cost, micro-structure similar to human skeleton, good features for promotion of osteogenesis, osteoinductivity and osteoconductivity, complete degradation in human body as well as no rejection, and consequentlyenjoys a bright market perspective.

Description

technical field [0001] The invention belongs to the technical field of tissue biomaterials, and in particular relates to a method for preparing implantable bone grafts by adopting deorganized 3D printing of animal bones. Background technique [0002] As the largest tissue and organ in the human body, bone bears important responsibilities for life activities, but it is the most likely to cause defects. Every year, millions of patients with bone tissue defects need surgical treatment. In my country, it is estimated that traffic accidents and production safety accidents cause traumatic fractures, spinal degenerative diseases, bone tumors, bone tuberculosis and other orthopedic diseases, resulting in millions of patients with bone defects or dysfunction. Bone grafts have become the most in-demand grafts after blood transfusions. How to find more and better materials for bone tissue regeneration has become the common pursuit and motivation of many scientists all over the world. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/28
CPCA61F2/28A61F2240/001
Inventor 涂洪波赵建华刘鹏刘明永刘遥遥殷翔范伟力
Owner THE THIRD AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIV OF PLA
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