Capsule-like gas contrast agent for gastrointestinal CT and application method thereof

Abstract

The invention discloses a capsule-like gas contrast agent for gastrointestinal CT and an application method thereof. According to the invention, a gas production agent and dimethicone powder (in a weight ratio of 4: 1) are mixed and then sealed in three enteric capsule shells with different wall thicknesses to prepare three contrast agent capsules with different wall thicknesses. The capsule-like gas contrast agent is capable of producing gas in gastrointestinal cavities and eliminating bubbles in intestinal mucus. In use, a capsule with a thickest wall is orally taken at first; then a capsule with a medium-thickness wall is orally taken in 15 min; a capsule with a thinnest wall is orally taken in another 15 min; and then gastrointestinal CT scanning is carried out in 15 min. Plain CT scanning may be carried out immediately after the capsule-like gas contrast agent is taken. The capsule-like gas contrast agent utilizes the characteristic of high contrast between the gastrointestinal wall and gas, so a low dosage of the capsule-like gas contrast agent can be used for CT scanning without influence on image diagnosis quality. The capsule-like gas contrast agent has the clinical application value of improvement of accuracy of CT images in displaying of gastrointestinal lesions and reduction in radiation harm of CT inspection to the stomach and intestine.

Description

technical field [0001] The present invention relates to a novel medicine and its application method. Background technique [0002] Gastrointestinal examination methods are limited, currently used clinically include gastrointestinal barium meal X-ray fluoroscopy, CT and MR examination, and recently applied gastrointestinal capsule endoscopy. Among these methods, barium X-ray examination can observe gastrointestinal function and obvious space-occupying obstruction of mucosal modifying agents, but it is difficult to diagnose early gastrointestinal lesions, subtle structural changes and extraintestinal changes. MR is limited in gastrointestinal examinations due to image artifacts caused by gastrointestinal wall peristalsis and intestinal fluid flow. Gastrointestinal capsule endoscopy can clearly show gastrointestinal mucosal changes and intraluminal mass, but cannot show submucosal lesions and extraluminal changes, and the examination is expensive and uncomfortable. CT has the...

AI Technical Summary

Problems solved by technology

[0004] In the applicant's further clinical practice, it was found that the gas-generating powder in the conventional parent-child type enteric-coated capsule shell easily absorbs moisture in the air under normal conditions, reducing the gas-generating efficiency

In particular, the gas-producing capsule is easy to crack in the same segment of the small intestine, and cannot obtain balanced gas production in all segments of the entire small intestine, and the imaging effect of the entire small intestine needs to be improved

Furthermore, the originally designed capsule dosage form: the gas-producing drug capsule is 0.6 g / capsule of the gas-generating agent, the muscle-relaxing drug capsule is 5 mg / capsule of the muscle-relaxing drug, and 10-15 capsules of the gas-producing drug capsule are required for each CT examination , this method of use requires a large amount of capsules, which is difficult for patients to accept; in addition, the gas generating agent produces bubbles on the surface of the intestinal mucosa, causing artifacts and affecting the observation of the mucosal structure

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