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Silver-carrying antibacterial hydrocolloid dressing and preparation method thereof

A hydrocolloid and silver-loaded technology, applied in medical science, absorbent pads, bandages, etc., can solve problems such as inability to use bactericides or adjuvants, limit the range of hydrocolloids to choose, reduce bactericidal activity, etc., to reduce biological safety risk, maintain the balance of skin flora, and increase the effect of antibacterial properties

Inactive Publication Date: 2017-02-01
HENAN HUIBO MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the antibacterial agent has strong antibacterial performance and good safety, it is an excellent antibacterial material that can be used for infected wounds, but this component belongs to cationic fungicides, so it cannot be combined with anionic fungicides or auxiliary agents. Compatible use, otherwise its bactericidal activity will be greatly reduced, which greatly limits the selection range of other hydrocolloid additives

Method used

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  • Silver-carrying antibacterial hydrocolloid dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1. Fully mix 20 parts of sodium carboxymethyl cellulose and 0.001 parts of silver-containing compound with superfine grinding and use it as component A; 2. Mix SIS thermoplastic elastomer (40 parts), 25 parts of liquid paraffin, viscosity increasing 5 parts of resin, 5 parts of antioxidant BHT, and 10 parts of plasticizer dioctyl adipate were sequentially added to the kneader at 150°C and 45 r / min, and mixed for 30 minutes, and the uniformly mixed material was used as component B; 1. Add component A into the kneader, stir at 120°C, 45r / min for 30min, and mix it evenly as component C; Add 3 parts of the material to component C, and stir for 10 minutes at 100°C and 45r / min; 5. Apply the uniformly mixed material on the isolation layer 3, and cover the polyurethane backing 1, and extinguish it by Co60 radiation. Bacteria can be made into finished products. When in use, the isolation layer 3 is removed, the hydrocolloid functional core 2 is pasted on the wound, and the back...

Embodiment 2

[0029] 1. Thoroughly mix 35 parts of sodium carboxymethyl cellulose and 0.5 parts of silver-containing compound with superfine grinding and use as component A; 2. Mix SIS thermoplastic elastomer (25 parts), 15 parts of liquid paraffin, viscosifying Add 10 parts of resin, 2.5 parts of antioxidant BHT, and 5 parts of plasticizer dioctyl adipate into the kneader in turn. Mix for 30 minutes under the conditions of 150 ° C and 45 r / min, and use the uniformly mixed material as component B. 3. Add component A to the kneader, stir for 30min at 120°C and 45r / min to make it evenly mixed as component C; Add 2.4 parts of skin extract to component C, and stir for 10 minutes at 100°C and 45r / min; 5. Apply the uniformly mixed material on the isolation layer 3, and cover the polyurethane backing 1, and pass through Co60 radiation According to sterilization, it can be made into a finished product. When in use, the isolation layer 3 is removed, the hydrocolloid functional core 2 is pasted on t...

Embodiment 3

[0031] 1. Superfinely mix 50 parts of sodium carboxymethyl cellulose and 5 parts of silver-containing compound and use it as component A; 2. Mix SIS thermoplastic elastomer (5 parts), 5 parts of liquid paraffin, Add 20 parts of resin, 0.01 part of antioxidant BHT, and 1 part of plasticizer dioctyl adipate into the kneader in turn. Mix for 30 minutes under the conditions of 150°C and 45 r / min, and use the uniformly mixed material as component B. 3. Add component A to the kneader, stir for 30 minutes at 120°C and 45r / min to make it evenly mixed as component C; Add 0.03 parts of skin extract to component C, and stir for 10 minutes at 100°C and 45r / min; 5. Apply the uniformly mixed material on the isolation layer 3, and cover the polyurethane backing 1, and pass through Co60 radiation According to sterilization, it can be made into a finished product. When in use, the isolation layer 3 is removed, the hydrocolloid functional core 2 is pasted on the wound, and the backing 1 is in ...

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Abstract

The invention discloses silver-carrying antibacterial hydrocolloid dressing and a preparation method thereof. The silver-carrying antibacterial hydrocolloid dressing is sequentially provided with a backing, a hydrocolloid functional dressing core and an isolation layer from top to bottom; the hydrocolloid functional dressing core is prepared from the following raw materials including sodium carboxymethylcellulose, an SIS thermoplastic elastomer, liquid paraffin, tackifying resin, an antioxidant, dioctyl adipate as a plasticizer, a bacteriostatic agent and a collaborative bacteriostatic agent. In a preparation process, the silver ion bacteriostatic agent and the plant extract collaborative bacteriostatic agent are added; with addition of the plant extract collaborative bacteriostatic agent, the addition concentration of the silver ion bacteriostatic agent is lowered when the antibacterial activity of the dressing is effectively improved; with addition of the silver ion bacteriostatic agent, the antibacterial wide adaptability and the antibacterial durability are both improved; and as the two bacteriostatic agents are used in a matching manner, a wound can be effectively prevented from being infected, and the silver-carrying antibacterial hydrocolloid dressing also has the advantages of blocking bacteria, absorbing exudate, avoiding wound adhesion, supplying an ideal wet healing environment for a wound, promoting healing of the wound and reducing formation of scars.

Description

technical field [0001] The invention belongs to the field of medical dressings, in particular to a silver-loaded antibacterial hydrocolloid dressing and a preparation method thereof. Background technique [0002] Human skin will cause trauma due to various external factors, thereby losing its natural protective function and causing other complications. Traditional gauze dressings are mainly made of cotton and linen raw materials through deep processing. The manufacturing process is simple, the price is low, and the use is convenient. However, traditional gauze dressings cannot maintain the moist environment required for wound healing, and tend to adhere to wound tissue, causing secondary mechanical damage during dressing changes. In addition, traditional dressings are not antibacterial, and the wound surface is susceptible to bacterial infection, producing unpleasant odors and causing wound complications, which is not conducive to wound healing. With the advancement of mod...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/46A61L15/44A61L15/42A61L15/28A61L15/24A61L15/20
CPCA61L15/46A61L15/20A61L15/24A61L15/28A61L15/42A61L15/44A61L2300/104A61L2300/30A61L2300/404C08L1/286C08L53/02
Inventor 曹晶晶李延浩周新钦张艳琦彭克林
Owner HENAN HUIBO MEDICAL CO LTD
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