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Use of xanthohumol in prevention and treatment of acute lung injury and acute respiratory distress syndrome

A technology for acute respiratory distress and acute lung injury, applied in the field of medicine, can solve the problems of reducing mortality and complicated pathogenesis, and achieve the effect of obvious clinical symptoms, good therapeutic effect and high cure rate

Inactive Publication Date: 2017-02-15
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complexity of its pathogenesis, although several large clinical trials have been used to explore a variety of treatment strategies (including the use of glucocorticoids, ketoconazole, the potential of inhaled NO or supplemental surfactants, etc.), so far it is still There is no feasible and effective treatment to reduce its mortality

Method used

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  • Use of xanthohumol in prevention and treatment of acute lung injury and acute respiratory distress syndrome
  • Use of xanthohumol in prevention and treatment of acute lung injury and acute respiratory distress syndrome
  • Use of xanthohumol in prevention and treatment of acute lung injury and acute respiratory distress syndrome

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0033] Therapeutic effect of xanthohumol on mice with acute lung injury in vivo

[0034] Establishment of acute lung injury model in mice: 60 male C57 / B mice (6-8 weeks old, 18-20g) were randomly divided into 6 groups, 10 mice in each group: blank group, LPS (0.5 mg / kg) group, Xanthohumol administration group (50 mg / kg), xanthohumol (10, 50 mg / kg) + LPS group, dexamethasone (5 mg / kg) + LPS group were used as positive control groups. Operation method: First, dilute xanthohumol and dexamethasone with normal saline and intraperitoneally inject mice, and the blank group and LPS group intraperitoneally inject equal volumes of normal saline. One hour after administration, LPS nasal instillation was used to establish the model, and mice in the blank group and xanthohumol-administered group were instilled with equal volumes of normal saline in the nasal cavity. After 12 hours of LPS instillation, the mice were sacrificed, and the bronchoalveolar lavage fluid (BALF) and lung tissues o...

experiment example 2

[0038] In vitro anti-inflammatory and antioxidant activities of xanthohumol and regulation of signaling pathways

[0039] Cell model establishment: the RAW 264.7 cells in the logarithmic growth phase were plated in a 96-well culture plate, and after 24 hours of culture, different concentrations of xanthohumol were added for 1 hour, and then LPS (1 μg / ml) was given for 24 hours. MTT was used to detect cytotoxicity; cells were plated in 24-well culture plates, and the treatment method was the same as above. (a) collected supernatants for ELISA to detect cytokines, collected cells for Western Bloting to detect the expression levels of iNOS, COX-2 and HMGB1; (b) prepared DCFH-DA (final concentration: 10 μM) was added to each well, placed in a 37 °C incubator for 30 min to detect ROS products.

[0040] The cells were spread in a 6-well culture plate, and after 24 hours of culture, they were treated with different concentrations of xanthohumol for 18 hours or treated with xanthohumo...

experiment example 3

[0044] Mechanisms of anti-inflammatory and antioxidant effects in vivo and in vitro

[0045] Establishment of acute lung injury model in vivo: In order to further explore the protective mechanism of xanthohumol on LPS-induced acute lung injury, wild-type (WT) and Nrf2 knockout (Nrf2 - / - ) mice to construct an LPS-induced mouse acute lung injury model (the modeling method is the same as above), and the lung tissue and alveolar lavage fluid (BALF) of the mice were collected for the following related experiments.

[0046] Experimental results: The protective mechanism of xanthohumol on mice with acute lung injury is as follows: Figure 7-10, xanthohumol significantly inhibited oxidative stress-induced Txinp activation and Trx-1 depletion, inhibited NLRP3 inflammasome and NF-κB inflammatory signaling pathways; significantly activated Nrf2, AMPK and GSK3β; significantly inhibited TNF-α, IL -6, IL-1β and ROS production, but in Nrf2 - / - Attenuated inhibition in mice; Nrf2 - / - In m...

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Abstract

The invention provides use of xanthohumol in the prevention and treatment of acute lung injury and acute respiratory distress syndrome. The xanthohumol can be used for preventing and treating the acute lung injury and the acute respiratory distress syndrome. By treating the acute lung injury or the acute respiratory distress syndrome by virtue of xanthohumol, the toxic and side effects are small, clinical symptoms are obvious, and the curing rate is high.

Description

technical field [0001] The invention discloses the use of xanthohumol in preventing and treating acute lung injury and acute respiratory distress syndrome, belonging to the field of medicine. Background technique [0002] Xanthohumol is a natural prenyl flavonoid compound extracted from hops, one of the important raw materials for industrial brewing of beer. It has anti-cancer, anti-virus, prevention and treatment of diabetes and atherosclerosis. effect. But there is no report about the use of xanthohumol in the treatment of acute lung injury. [0003] Acute lung injury (ALI) and its severe form acute respiratory distress syndrome (ARDS) are caused by various factors such as trauma, blood transfusion and infection. Pulmonary edema is a pathophysiological feature of acute progressive respiratory insufficiency or respiratory failure and is the leading cause of death in intensive care. The pathogenesis of acute lung injury is complex, mainly involving various pathways such a...

Claims

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Application Information

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IPC IPC(8): A61K31/12A61P11/00
CPCA61K31/12
Inventor 慈鑫鑫吕红明温中梅于钦磊
Owner JILIN UNIV
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