Phellinus igniarius alcohol extract and application thereof in uremia medicine

A technology of Phellinus linteus extract and uremia, which is applied in the field of medicine, can solve the problems of aggravation of the disease, large toxic and side effects, increase serum creatinine and urea, etc., achieves broad application prospects, reduces pathological damage, and improves the effects of renal function.

Inactive Publication Date: 2017-02-22
NORTHWEST UNIV(CN)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although western medicine has a certain curative effect, it has the disadvantages of large toxic side effects and high recurrence rate. For example, medicinal activated charcoal is effective in the initial stage of the disease, but it will aggravate the disease in the later stage. It cannot improve the increase of blood creatinine and urea, and symptoms that are difficult to control , which will eventually develop into more serious consequences

Method used

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  • Phellinus igniarius alcohol extract and application thereof in uremia medicine
  • Phellinus igniarius alcohol extract and application thereof in uremia medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The preparation of embodiment 1 Phellinus Phellinus ethanol extract

[0016] At present, the methods of extracting medicinal materials include percolation method, heating reflux method, ultrasonic extraction method, Soxhlet extraction method and so on. The applicant adopts a simple and quick ultrasonic extraction method to investigate Phellinus after being dried and crushed, soaked with 6-8 times the volume of 85% ethanol for about 24 hours, ultrasonic time (15 minutes, 30 minutes, 45 minutes, 60 minutes) and Effect of ultrasonic times (2 times and 3 times) on extraction rate (extracted extract / crude drug amount). The results showed that under the premise of ultrasonic extraction twice, the extraction rates were 2.0%, 2.2%, 2.7%, and 3.2% when the ultrasonic time was 15 minutes, 30 minutes, 45 minutes, and 60 minutes; Under the conditions, the extraction rates were 2.5%, 2.9%, 3.5%, and 3.7% when the ultrasonic time was 15 minutes, 30 minutes, 45 minutes, and 60 minute...

Embodiment 2

[0018] In order to verify the effect of Phellinus ethanol extract on the treatment of uremia, the applicant used the adenine-induced uremia rat model to conduct a pharmacodynamic test. The various test conditions are as follows:

[0019] 1. Experimental drugs and experimental animals

[0020] Phellinus ethanol extract suspension, prepared with tap water containing 2% gum arabic powder. Healthy male SD rats, weighing 220-240 g, were purchased from the Animal Center of Fourth Military Medical University.

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Abstract

The invention discloses a phellinus igniarius alcohol extract, which is extracted through a following extraction method comprising the steps of after smashing phellinus igniarius, soaking with 80 to 95 percent ethyl alcohol in 6 to 8 times of volume for 12 to 36 hours, ultrasonic extracting for 3 to 5 times, recovering the ethyl alcohol, and concentrating to obtain a brown paste object. The phellinus igniarius alcohol extract provided by the invention can be beneficial to reducing renal function biochemical criterions such as blood urea and serum creatinine, improving a renal function, and reducing the pathological damage of adenine metabolite on a kidney so as to have a better protection function, provides a new medicine for clinically treating uremia, and has a wide application prospect.

Description

technical field [0001] The invention relates to a new application of Phellinus ethanol extract for treating uremia in a body, and belongs to the technical field of medicine. Background technique [0002] Uremia is one of the major diseases affecting human health. The incidence of uremia continues to rise along with the increasing prevalence of hypertension and diabetes. Uremia refers to the irreversible loss of renal function and nephrons on the basis of various chronic kidney diseases, resulting in a clinical syndrome characterized by metabolic products, acid-base balance disorders, and endocrine disorders. Statistics from the International Society of Nephrology show that the annual incidence of uremia in the natural population is 98-198 / 1 million, and the incidence rates in economically developed Japan and the United States are 996 / 1 million and 802 / 1 million, respectively. [0003] At present, medical therapy, dialysis therapy and kidney transplantation are commonly use...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/07A61P13/12
CPCA61K36/07A61K2236/333A61K2236/39
Inventor 赵英永陈华
Owner NORTHWEST UNIV(CN)
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