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Method for detecting phthalic acid bis(2-ethyl)hexyl acrylate in traditional Chinese medicine decoction

A technology of phthalic acid and traditional Chinese medicine, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of difficult promotion, high detection cost, long detection time, etc.

Active Publication Date: 2017-02-22
SHANGHAI TONGJI HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Previous PAEs detection methods have the following disadvantages: the detection time is too long, the peak time is unstable, the price is expensive, the detection cost is high, and it is not easy to promote

Method used

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  • Method for detecting phthalic acid bis(2-ethyl)hexyl acrylate in traditional Chinese medicine decoction
  • Method for detecting phthalic acid bis(2-ethyl)hexyl acrylate in traditional Chinese medicine decoction
  • Method for detecting phthalic acid bis(2-ethyl)hexyl acrylate in traditional Chinese medicine decoction

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Experimental program
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Embodiment

[0054] Instruments and reagents

[0055] Agilent1100 high performance liquid chromatography (degassing device Agilent G1322A, quaternary pump Agilent G1311A, column oven Agilent G1316A, ultraviolet detector Agilent G1314A); constant temperature water bath HWS-26 (Huitai Instruments); electronic balance (Mettler- Toledo company ME204); precision electronic balance (Mettler - Toledo company XS105DU). Di(2-ethyl)hexyl phthalate standard substance (aladdin company); Anhydrous sodium sulfate (AR Lingfeng company 7757-82-6); n-hexane (AR Lingfeng company 110-54-3); Methanol (AR Lingfeng 67-56-1); liquid phase methanol and acetonitrile (Merck); self-made distilled water. Batch number of traditional Chinese medicine liquid packaging bag: SH101024 (Changchun Boya).

[0056] Take Chinese herbal medicines (100g each of Codonopsis pilosula, Astragalus membranaceus and Chinese yam) and add 4000ml of distilled water in a Chinese medicine decoction machine, decoct for one hour, take the me...

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Abstract

The invention provides a method for detecting phthalic acid bis(2-ethyl)hexyl acrylate (DEHP) in traditional Chinese medicine decoction packing materials through high performance liquid chromatography. Chromatographic column separation is adopted, acetonitrile, methyl alcohol and water are adopted as a moving phase, and a method capable of detecting trace DEHP is obtained by optimizing flow speed, column temperature, wave length and other conditions. According to the method, the mass concentrations and peak areas of all components have a good linear relation, correlation coefficients are all larger than 0.999, and the phthalic acid bis(2-ethyl)hexyl acrylate component is well separated within 5 min. The detection limit is 1.534566 mg / L, the recovery rate is 101.5948%, the instrument precision relative standard deviation is 0.501%, and the method relative standard deviation (RSD) is 2.101%.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine analysis, and in particular relates to a method for detecting bis(2-ethyl)hexyl phthalate in traditional Chinese medicine substitute decoction by using high performance liquid chromatography. Background technique [0002] Plasticizers are phthalates (PAEs), also known as phthalates, because they can enhance the toughness and plasticity of plastics and reduce the processing temperature, so they are widely used in plastic packaging. Under certain conditions, PAEs can migrate out of plastic packaging, and residual PAEs in medical plastic packaging may migrate into pharmaceuticals and cause pollution. After being ingested by the human body, PAEs will interfere with the normal endocrine function of the body, and long-term accumulation in the body will lead to more serious consequences. After the "plasticizer" incident was exposed, the presence of PAEs was detected one after anothe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 成冬海祝德秋
Owner SHANGHAI TONGJI HOSPITAL