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Injectable bone substitutes for augmenting implant fixation

A technology for implants, uses, applications, bone diseases, drug combinations, etc.

Inactive Publication Date: 2017-03-08
BONE SUPPORT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Revision arthroplasty presents substantial challenges to the surgeon if the primary prosthesis is already engaged with polymethylmethacrylate (PMMA)

Method used

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  • Injectable bone substitutes for augmenting implant fixation
  • Injectable bone substitutes for augmenting implant fixation
  • Injectable bone substitutes for augmenting implant fixation

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0079] Preparation of the bone cavity may require removal of damaged bone, and in the case of removal of a pre-existing prosthesis, this may include removal of the PMMA cement to provide a bone cavity suitable to receive and secure the prosthesis. Suitably, a straight box or offset chisel may be used to orient the bone canal into which the prosthesis is to be implanted, and the canal cleared to accept a starter reamer. Opening into the distal portion of the bone canal can then be initiated using a single priming reamer on the T-handle, where the reamer is introduced to a level appropriate for preoperative X-ray templated prosthesis dimensions. The proximal portion of the bone canal can then be enlarged using one or more upsizing broaches until a template implant size is reached, which is selected to ensure a tight fit of the prosthesis to be implanted. After the bone substitute composition has been introduced into the cavity, the prosthetic stem can be advanced into place by a...

Embodiment 1

[0102] Example 1 Preparation of injectable biphasic ceramic bone substitute composition

[0103] In this example, three different types of hardenable ceramic bone substitute materials were prepared. All three samples consisted of 59.6wt% α-CSH, 40.0wt% HA, 0.4wt% CSD, and had the same liquid-to-powder ratio (L / P=0.43mL / g), but the liquid phase and the added There are different types of compounds, see the table below.

[0104] sample name liquid phase Added compound CSH / HA Iohexol (180mg I / mL) - CSH / HA+gentamycin brine Gentamicin Sulfate CSH / HA+Vancomycin Iohexol (180mg I / mL) Vancomycin Hydrochloride

[0105] CSH / HA

[0106] Mixing 11.6 g of ceramic bone substitute with 5.0 mL of a liquid phase containing iohexol (180 mg I / mL) resulted in an L / P ratio of 0.43 mL / g. Mix for 30 seconds using a specially designed mixing and injection device (WO 2005 / 122971). The resulting paste can be injected with a 16G needle for up to 5 minutes an...

Embodiment 2

[0114] Example 2 Demonstration of Injectable Biphasic Ceramic Bone Substitute Compositions Comprising Vancomycin Enhances Implant Fixation Using a Model System

[0115] The effect of the injectable composition prepared according to Example 1 on implant fixation was determined in a model system by determining the pull-out force and torsion resistance of screws inserted into cancellous bone models that had been augmented with the injectable composition.

[0116] The spongy bone model consists of (Sawbones.com) rigid open cell foam block (Product No. 1522-507). The foam block has a more than 95% open pore structure with an open cell size of 1.5-2.5 mm, similar to human cancellous bone, making it suitable for dynamic testing or cement injection. The foam block has a density of 0.12g / cc, a compressive strength of 0.28MPa, and a compressive modulus of 18.6MPa, which are relatively low in the order and are used because they most closely simulate osteoporotic bone, where the fixatio...

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Abstract

The invention relates to the use of a cyclic glycopeptide to enhance the resistance of a composition to one or more of a tensile, shear and torsional force, where the composition comprises a bone substitute powder, an aqueous liquid and the cyclic glycopeptide. The invention also relates to a composition for use in the treatment of a musculoskeletal disorder in a mammal receiving an implant to enhance bone re-growth for stabilization of the implant, and to a method for the use of the composition in treatment of the mammal. The composition comprises a bone substitute powder, an aqueous liquid and a cyclic glycopeptide.

Description

technical field [0001] The present invention relates to the use of cyclic glycopeptides for enhancing the resistance of a bone substitute composition to one or more of tensile, shear and torsional forces. The bone substitute composition, when mixed, forms an injectable and / or moldable and hardenable composition useful in orthopedic surgery, wherein said composition is used in combination with an implant to enhance fixation of the implant, thereby Enhances bone regrowth required for implant stability. Background technique [0002] Until the last century, doctors relied on casts and splints to support and stabilize bones from outside the body. The advent of sterile surgery has reduced the risk of infection and allowed doctors to set and stabilize fractured bones from the inside. Implants are now widely used in orthopedic surgery, for repairing broken bones, and for arthroplasty. Internal fixation is used to stabilize and support the broken bone until it is strong enough to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/04A61L27/54
CPCA61L27/025A61L27/12A61L27/54A61L24/02A61L24/0015A61K38/14A61P19/00A61L2300/252A61L2400/06A61L2300/406A61L2430/02
Inventor 阿吉里斯·卡西欧普塔斯伊娃·克里斯蒂娜·丽登比约恩·弗雷德里克·林德贝里
Owner BONE SUPPORT
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