Composition for preventing and treating cardiac insufficiency and application thereof

A technology for cardiac insufficiency and a composition, applied in the field of medicine, can solve problems such as cardiac insufficiency, and achieve the effects of improving blood pressure, obvious social benefits and economic value, and having a wide range of sources.

Inactive Publication Date: 2017-03-15
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no relevant report on using polydatin as the main active ingredient, especially the combination of polydatin and vitamin C for the prevention and treatment of cardiac insufficiency

Method used

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  • Composition for preventing and treating cardiac insufficiency and application thereof
  • Composition for preventing and treating cardiac insufficiency and application thereof
  • Composition for preventing and treating cardiac insufficiency and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0022] 1 material

[0023] 1.1 Drug preparation

[0024] Preparation of 0.5% sodium carboxymethyl cellulose: Precisely weigh 1 g of sodium carboxymethyl cellulose powder (batch number: F20090916, Sinopharm Chemical Reagent Co., Ltd.), gradually add it into boiled distilled water to dissolve, stir while dissolving, until complete Dissolved and formulated to the corresponding concentration.

[0025] Preparation of 10 μmol / mL Polygoniside Solution: Precisely weigh 195mg Polygonin (purity 98.7%, batch number: ZL20120907YY, Nanjing Zelang Pharmaceutical Technology Co., Ltd.), and prepare it with 0.5% sodium carboxymethylcellulose to 50mL.

[0026] Preparation of 10 μmol / mL vitamin C solution: Precisely weigh 88 mg of vitamin C (batch number: 20130801, Sinopharm Chemical Reagent Co., Ltd.), and prepare it to 50 mL with 0.5% sodium carboxymethylcellulose.

[0027] Preparation of the composition solution of polydipside and vitamin C: the 10 μmol / mL polydatin solution prepared above ...

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PUM

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Abstract

The invention discloses a composition for preventing and treating cardiac insufficiency and applications thereof. The composition is composed of polydatin and vitamin C according to the molar ratio of 1:(0.01-100). A test proves that the composition is better than each of polydatin or vitamin C in treatment on abnormity of cardiac structure, treatment of abnormity of blood pressure, heart rate and electrocardiography, treatment on myocardial mitochondria energy metabolic disorder, and activity of resisting oxidizing stress reactions. The two components have significant synergistic effects, so that the composition can be used for producing health-caring products for preventing cardiac insufficiency as an active component, or is used for producing medicines for preventing/treating the cardiac insufficiency as an active component, thereby reducing incidence of arrhythmia, reduction of cardiac pumping function, sudden death and the like of cardiac insufficient patients. The polydatin and the vitamin C in the composition are wide in sources, are safe and low-toxicity and are low in cost. The composition is very suitable for promotion in large scale.

Description

technical field [0001] The invention relates to a composition for preventing and treating cardiac insufficiency and its application, belonging to the technical field of medicine. Background technique [0002] Cardiac insufficiency, also known as heart failure (heart failure for short), is a clinical syndrome in which the pumping function of the heart is reduced due to a variety of causes and cannot discharge enough blood to meet the metabolic needs of systemic tissues and organs. The outcome of the progression of sexual heart disease is one of the important cardiovascular diseases and one of the leading causes of death. The main causes of clinical cardiac insufficiency include hypertension, myocardial infarction, cardiomyopathy, pulmonary hypertension, diabetes, hyperthyroidism, etc. Since cardiac insufficiency is a common disease with many causes and types, it is mainly treated by nourishing qi, nourishing yin, promoting blood circulation and removing blood stasis. , the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034A23L33/00A61P9/04A61K31/375
Inventor 高建平王会琳武容崔肖华姚平安
Owner SHANGHAI UNIV OF T C M
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