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Lidocaine hydrochloride cavity lubrication defoaming agent

A technology of lidocaine hydrochloride and lubricant, applied in the field of medicine, can solve the problems of early diagnosis and discovery of unfavorable digestive tract diseases, increase patient pain, long examination time, etc., and achieve the effects of improving clarity, reducing pain, and accelerating removal

Active Publication Date: 2017-03-15
SHANDONG WEIGAO HONGRUI MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during the diagnosis process, due to the presence of a large amount of foam and mucus in the digestive tract, the visual field is unclear, the examination time is long, the patient’s pain is increased, and it is easy to cause misdiagnosis and missed diagnosis, which is not conducive to the early diagnosis and detection of digestive tract diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] (1) Add 2 parts by weight of sodium carboxymethyl cellulose to 100 parts by weight of water to swell, and stir under the condition of 100-300 rpm until completely in water to obtain a lubricant solution,

[0040] (2) 2 weight parts of lidocaine hydrochloride are passed through a 100-mesh sieve, and then added to the lubricant solution obtained in step (1) to obtain agent A;

[0041] Preparation method of agent B:

[0042] (1) Mix 4.8 parts by weight of polydimethylsiloxane, 0.1 parts by weight of silicon dioxide, 2.5 parts by weight of Tween-80 and 0.7 parts by weight of Span-80 for 15-30 minutes to obtain the defoaming agent,

[0043] (2) Add 2 parts by weight of neutral protease, 3 parts by weight of trypsin and 50 parts by weight of sodium bicarbonate, 130 parts by weight of xylitol in the mixed material of step (1), at 60-150 rpm Continue to mix for 10-30min under the condition to obtain agent B;

[0044] Add 1-10g of agent B into 100ml of agent A, stir and mix e...

Embodiment 2

[0046] (1) Add 0.5 parts by weight of hydroxypropyl methylcellulose to 97.5 parts by weight of water to swell, and stir under the condition of 100-300 rpm until completely dissolved in water to obtain a lubricant solution,

[0047] (2) 2 weight parts of lidocaine hydrochloride are passed through a 100-mesh sieve, and then added to the lubricant solution obtained in step (1) to obtain agent A;

[0048] Preparation method of agent B:

[0049] (1) Mix 0.95 parts by weight of polydimethylsiloxane, 0.05 parts by weight of silicon dioxide, 2.3 parts by weight of Tween-80 and 1.7 parts by weight of Span-80 for 15-30 minutes to obtain defoaming agent,

[0050] (2) Add 15 parts by weight of neutral protease, 25 parts by weight of trypsin, 25 parts by weight of sodium bicarbonate, and 80 parts by weight of sorbitol in the mixed material of step (1), at 60-150 rpm Continue to mix for 10-30 minutes to obtain agent B;

[0051] Add 1-10g of agent B into 100ml of agent A, stir and mix evenl...

Embodiment 3

[0053] (1) Add 1.5 parts by weight of sodium alginate to 99.5 parts by weight of water to swell, and stir under the condition of 100-300 rpm until completely dissolved in water to obtain a lubricant solution,

[0054] (2) The lidocaine hydrochloride of 5.0 weight parts is crossed 100 mesh sieves, then joins in the lubricant solution that step (1) obtains, obtains A agent;

[0055] Preparation method of agent B:

[0056] (1) Mix 3.85 parts by weight of polydimethylsiloxane, 0.45 parts by weight of silicon dioxide, 2.0 parts by weight of Tween-80 and 1.5 parts by weight of Span-80 for 15-30 minutes to obtain defoaming agent,

[0057] (2) Add 18 parts by weight of neutral protease, 30 parts by weight of trypsin, 20 parts by weight of disodium hydrogen phosphate, and 120 parts by weight of lactose into the mixed material of step (1), at 60-150 rpm Continue to mix for 10-30 minutes to obtain agent B;

[0058] Add 1-10g of agent B into 100ml of agent A, stir and mix evenly to obt...

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Abstract

The invention provides a lidocaine hydrochloride cavity lubrication defoaming agent, which comprises an agent A and an agent B. The agent A comprises, by weight, 0.5-5.0 parts of lidocaine hydrochloride, 0.1-2.0 parts of a lubricant and 90-100 parts of water. The agent B comprises, by weight, 10-60 parts of protease, 1.0-10 parts of a defoaming agent and 40-200 parts of an excipient. By steps of adding 1-10 g of the agent B into 100 ml of the agent A and mixing and adjusting pH to 6.0-8.5, the lidocaine hydrochloride cavity lubrication defoaming agent is obtained. The lidocaine hydrochloride cavity lubrication defoaming agent of the invention has an obvious lubricating effect on the digestive tract, can help reduce damage of an endoscope to the cavity when the endoscope enters the body cavity, can help reduce pains of patients during endoscopy and decrease spasm of esophagus and stomach, and is convenient for smooth detection under the endoscope.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a lidocaine hydrochloride cavity lubricating and defoaming agent, which is used for adjuvant medication before endoscopic examination and treatment of digestive tract or imaging examination. Background technique [0002] Gastrointestinal endoscopy refers to a tubular instrument inspection that can directly visualize the lesions of the gastrointestinal tract and abdominal organs under light illumination. It can not only confirm the diagnosis obtained by other inspection methods, but also make it difficult Diagnosed early-stage lesions are diagnosed, especially for the discovery of early-stage cancers of the digestive tract. However, during the diagnosis process, due to the large amount of foam and mucus in the digestive tract, the visual field is unclear, the examination time is long, the patient is suffering, and it is easy to cause misdiagnosis and missed diagnosis...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K38/48A61K31/167A61K47/38A61K47/36A61P1/00
Inventor 杜武华黄显峰林栋青王江尹翠竹程龙
Owner SHANDONG WEIGAO HONGRUI MEDICAL TECH CO LTD
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