Lidocaine hydrochloride cavity lubrication defoaming agent

A technology of lidocaine hydrochloride and lubricant, applied in the field of medicine, can solve the problems of early diagnosis and discovery of unfavorable digestive tract diseases, increase patient pain, long examination time, etc., and achieve the effects of improving clarity, reducing pain, and accelerating removal

Active Publication Date: 2017-03-15
SHANDONG WEIGAO HONGRUI MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during the diagnosis process, due to the presence of a large amount of foam and mucus in the digestive tract, the visual field is unclear, the examination time is long,

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0038] Example 1

[0039] (1) 2 weight parts of sodium carboxymethyl cellulose is added to 100 weight parts of water to swell, stirred to be completely in water under the condition of 100-300 rev / min, to obtain lubricant solution,

[0040] (2) the lidocaine hydrochloride of 2 weight parts is crossed 100 mesh sieves, and then joins in the lubricant solution that step (1) obtains, obtains A agent;

[0041] Preparation method of agent B:

[0042] (1) 4.8 parts by weight of polydimethylsiloxane, 0.1 part by weight of silicon dioxide, 2.5 parts by weight of Tween-80 and 0.7 part by weight of Span-80 were mixed for 15-30min to obtain defoaming agent,

[0043] (2) adding 2 parts by weight of neutral protease, 3 parts by weight of trypsin and 50 parts by weight of sodium bicarbonate, 130 parts by weight of xylitol to the mixed material in step (1), at 60-150 rev / min Continue to mix for 10-30min under conditions to obtain agent B;

[0044] Add 1-10 g of agent B to 100 ml of agent A...

Example Embodiment

[0045] Example 2

[0046] (1) 0.5 weight portion of hydroxypropyl methylcellulose is added to 97.5 weight portions of water to swell, stirred to be completely in water under the condition of 100-300 rev / min, to obtain lubricant solution,

[0047] (2) the lidocaine hydrochloride of 2 weight parts is crossed 100 mesh sieves, and then joins in the lubricant solution that step (1) obtains, obtains A agent;

[0048] Preparation method of agent B:

[0049] (1) 0.95 parts by weight of polydimethylsiloxane, 0.05 parts by weight of silicon dioxide, 2.3 parts by weight of Tween-80 and 1.7 parts by weight of Span-80 were mixed for 15-30min to obtain defoaming agent,

[0050] (2) adding 15 parts by weight of neutral protease, 25 parts by weight of trypsin and 25 parts by weight of sodium bicarbonate, 80 parts by weight of sorbitol to the mixed material in step (1), at the condition of 60-150 rev / min Continue to mix for 10-30min to obtain agent B;

[0051] Add 1-10 g of agent B to 100 ml...

Example Embodiment

[0052] Example 3

[0053] (1) 1.5 parts by weight of sodium alginate is added to 99.5 parts by weight of water to swell, and under the condition of 100-300 rev / min, it is stirred to be completely in water to obtain lubricant solution,

[0054] (2) 5.0 parts by weight of lidocaine hydrochloride is passed through a 100-mesh sieve, and then added to the lubricant solution obtained in step (1) to obtain agent A;

[0055] Preparation method of agent B:

[0056] (1) 3.85 parts by weight of polydimethylsiloxane, 0.45 parts by weight of silicon dioxide, 2.0 parts by weight of Tween-80 and 1.5 parts by weight of Span-80 were mixed for 15-30min to obtain defoaming agent,

[0057] (2) adding 18 parts by weight of neutral protease, 30 parts by weight of trypsin, 20 parts by weight of disodium hydrogen phosphate, and 120 parts by weight of lactose to the mixed material in step (1), at a condition of 60-150 rpm Continue to mix for 10-30min to obtain agent B;

[0058] Add 1-10 g of agent...

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Abstract

The invention provides a lidocaine hydrochloride cavity lubrication defoaming agent, which comprises an agent A and an agent B. The agent A comprises, by weight, 0.5-5.0 parts of lidocaine hydrochloride, 0.1-2.0 parts of a lubricant and 90-100 parts of water. The agent B comprises, by weight, 10-60 parts of protease, 1.0-10 parts of a defoaming agent and 40-200 parts of an excipient. By steps of adding 1-10 g of the agent B into 100 ml of the agent A and mixing and adjusting pH to 6.0-8.5, the lidocaine hydrochloride cavity lubrication defoaming agent is obtained. The lidocaine hydrochloride cavity lubrication defoaming agent of the invention has an obvious lubricating effect on the digestive tract, can help reduce damage of an endoscope to the cavity when the endoscope enters the body cavity, can help reduce pains of patients during endoscopy and decrease spasm of esophagus and stomach, and is convenient for smooth detection under the endoscope.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a lidocaine hydrochloride cavity lubricating and defoaming agent, which is used for adjuvant medication before endoscopic examination and treatment of digestive tract or imaging examination. Background technique [0002] Gastrointestinal endoscopy refers to a tubular instrument inspection that can directly visualize the lesions of the gastrointestinal tract and abdominal organs under light illumination. It can not only confirm the diagnosis obtained by other inspection methods, but also make it difficult Diagnosed early-stage lesions are diagnosed, especially for the discovery of early-stage cancers of the digestive tract. However, during the diagnosis process, due to the large amount of foam and mucus in the digestive tract, the visual field is unclear, the examination time is long, the patient is suffering, and it is easy to cause misdiagnosis and missed diagnosis...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K38/48A61K31/167A61K47/38A61K47/36A61P1/00
Inventor 杜武华黄显峰林栋青王江尹翠竹程龙
Owner SHANDONG WEIGAO HONGRUI MEDICAL TECH CO LTD
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