Biodegradable mesoporous carbon and silicon nano-sphere and method for preparing same

A biodegradable, silicon nanotechnology, applied in nanotechnology, nanotechnology, nanotechnology, etc. for materials and surface science, can solve problems such as tissue damage, achieve high specific surface area, improve compatibility, good biodegradability degradability effect

Active Publication Date: 2017-03-22
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the inability to degrade in time, mesoporous inorganic nanospheres will accumulate in the liver and spleen, which will cause severe tissue damage

Method used

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  • Biodegradable mesoporous carbon and silicon nano-sphere and method for preparing same

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] (1) Add 6 g of cetyltrimethylammonium chloride (CTAC) and 0.18 g of triethanolamine (TEA) into 55 ml of water, and stir at 60° C. for 1 hour. Add 20 ml of n-hexane solution of tetraethyl orthosilicate (TEOS), the volume ratio of TEOS to n-hexane is 1:6. After 18 hours of reaction, it was centrifuged. The obtained solid product was added to 60 ml of 0.5 wt % ammonium nitrate ethanol solution, and stirred at 60° C. for 5 hours. Centrifuge, wash with ethanol three times, and dry to obtain biodegradable mesoporous silica nanospheres.

[0044] (2) Add 0.2 gram of biodegradable mesoporous silica nanospheres obtained in step (1) and 2 milliliters of γ-aminopropyltriethoxysilane (APTES) to 50 milliliters of toluene and stir at 80°C 10 hours. Centrifugal separation, washing with water and drying to obtain aminated biodegradable mesoporous silica nanospheres.

[0045] (3) Add 0.2 g of the aminated biodegradable mesoporous silica nanospheres obtained in step (2) and 0.06 g of ...

Embodiment 2

[0048] (1) Add 6 g of CTAC and 0.18 g of TEA into 55 ml of water, and stir at 60° C. for 1 hour. Add 20 ml of TEOS in n-hexane solution, the volume ratio of TEOS to n-hexane is 1:8. After 12 hours of reaction, it was centrifuged. The obtained solid product was added to 60 ml of 0.5 wt % ammonium nitrate ethanol solution, and stirred at 60° C. for 5 hours. Centrifuge, wash with ethanol three times, and dry to obtain biodegradable mesoporous silica nanospheres.

[0049] (2) Add 0.2 g of biodegradable mesoporous silica nanospheres obtained in step (1) and 2 ml of APTES into 50 ml of toluene, and stir at 80° C. for 10 hours. Centrifugal separation, washing with water and drying to obtain aminated biodegradable mesoporous silica nanospheres.

[0050] (3) Add 0.2 g of the aminated biodegradable mesoporous silica nanospheres obtained in step (2) and 0.05 g of glucose into 20 ml of water, and conduct a hydrothermal reaction at 150° C. for 24 hours. The solid product was separated ...

Embodiment 3

[0053] (1) Add 6 g of CTAC and 0.18 g of TEA into 55 ml of water, and stir at 60° C. for 1 hour. Add 20 ml of TEOS in n-hexane solution, the volume ratio of TEOS to n-hexane is 1:4. After 24 hours of reaction, it was centrifuged. The obtained solid product was added to 60 ml of 0.5 wt % ammonium nitrate ethanol solution, and stirred at 60° C. for 5 hours. Centrifuge, wash with ethanol three times, and dry to obtain biodegradable mesoporous silica nanospheres.

[0054] (2) Add 0.2 g of biodegradable mesoporous silica nanospheres obtained in step (1) and 2 ml of APTES into 50 ml of toluene, and stir at 80° C. for 10 hours. Centrifugal separation, washing with water and drying to obtain aminated biodegradable mesoporous silica nanospheres.

[0055] (3) Add 0.2 g of the aminated biodegradable mesoporous silica nanospheres obtained in step (2) and 0.08 g of glucose into 20 ml of water, and conduct a hydrothermal reaction at 170° C. for 12 hours. The solid product was separated ...

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Abstract

The invention discloses a mesoporous carbon and silicon nano-sphere and a method for preparing the same. The mesoporous carbon and silicon nano-sphere comprises mesoporous silicon dioxide nano-spheres and carbon. The mesoporous silicon dioxide nano-spheres are biodegradable nano-spheres; the carbon is distributed on the surfaces of hole walls of the mesoporous silicon dioxide nano-spheres. The method includes carrying out hydrothermal polymerization on the surfaces of the hole walls of the biodegradable mesoporous silicon dioxide nano-spheres by the aid of carbon sources such as glucose; carbonizing the biodegradable mesoporous silicon dioxide nano-spheres to obtain the biodegradable mesoporous carbon and silicon nano-sphere. The mesoporous carbon and silicon nano-sphere and the method have the advantage that the mesoporous carbon and silicon nano-sphere is excellent in biodegradability.

Description

technical field [0001] The invention relates to a mesoporous carbon-silicon nanosphere and a preparation method thereof, in particular to a biodegradable mesoporous carbon-silicon nanosphere and a preparation method thereof. Background technique [0002] With the vigorous development of nanotechnology, the application of nanoporous materials in the field of drug delivery and controlled release has attracted widespread attention. Drugs are bound to nanoporous materials by adsorption, coating or chemical bonding. Nanoporous materials are much smaller in size than capillaries, and can deliver loaded drugs to various tissues and organs of the human body. The nanoporous material has a sustained release effect, thus extending the half-life of the drug. On the premise of achieving the same drug effect, the dosage of the drug can be reduced, and the toxic and side effects of the drug can be reduced or eliminated at the same time. [0003] At present, most of the biodegradable nan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B33/12B82Y30/00A61K47/04A61K9/14
CPCA61K9/143A61K47/02C01B33/12C01P2004/04C01P2004/62C01P2004/64C01P2004/80C01P2006/12C01P2006/16
Inventor 刘惠玉顾凯王弘毓黄志军
Owner BEIJING UNIV OF CHEM TECH
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