1, 5-diaryl-1, 2, 4-triazole compounds and pharmacy use thereof

A technology of triazoles and compounds, applied in drug combinations, organic chemistry, antineoplastic drugs, etc.
CN106543092AActive Publication Date: 2017-03-29EAST CHINA NORMAL UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
EAST CHINA NORMAL UNIV
Publication Date
2017-03-29

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Abstract

The invention discloses 1, 5-diaryl-1, 2, 4-triazole compounds or pharmaceutically acceptable salts thereof shown as structural formula (I)-(III), and pharmaceutical compositions containing the compounds. The invention also discloses application of the compounds or pharmaceutically acceptable salts thereof in preparation of drugs for treatment of various malignant tumors and tumor metastasis related diseases. The compounds shown as formula (I)-(III) can realize concentration gradient dependent inhibition of the proliferation, invasion, infiltration and the like of breast cancer cells, prostate cancer cells, colon cancer cells, liver cancer cells, non-small cell lung cancer cells, bladder cancer cells and other tumor cells, have low toxicity, and have wide application prospects in bio-pharmaceutical industry.
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Description

technical field

[0001] The invention relates to a class of 1,5-diaryl-1,2,4-triazole compounds and related analogues, and the compounds or pharmaceutical compositions containing them can be used to prepare and treat various malignant Drugs for tumors and related diseases of tumor metastasis. The invention also relates to a preparation method of the 1,5-diaryl-1,2,4-triazole compound. Background technique

[0002] Cancer, also known as malignant tumor, is one of the main causes of disease death worldwide. Nowadays, the morbidity and mortality of many cancers are still showing a trend of rapid growth, seriously endangering human health. According to statistics from the American Cancer Society, the main cause of clinical death of more than 90% of cancer patients is not tumor growth in situ, but distant metastasis of tumor cells.

[0003] Tumor metastasis is a complex process: tumor cells are released from the primary tumor site and invade surrounding tissues, enter the blood...

Claims

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