Application of Zedoary turmeric oil in preparation of camphor and isolation and extraction method of Zedoary turmeric oil

A technology of zedoary turmeric oil and camphor, which is applied in the field of extracting and preparing camphor from volatile oil of traditional Chinese medicine turmeric oil, can solve the problems of large environmental pollution, waste, and difficulty in realizing industrialized production, and achieves the effects of reducing manpower and material resources, simple preparation method and favorable industrialization.

Inactive Publication Date: 2017-04-26
DALIAN DEZE PHARMA CO LTD
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Camphor is mainly extracted from lauraceae plants such as camphor leaves. In the prior art, the extraction method of natural camphor has harsh conditions and needs to be carried out at ultra-low temperature (-33~-78 ° C), which is difficult to realize industrial production.
Chinese patent application 201510714006.X reports a method for refining camphor through isoborneol, but this method has defects such as high production cost, large environmental pollution, and low efficiency
A large number of by-products produced during the industrial production of zedoary oil to prepare elemene, these by-products are not well utilized at present, resulting in a certain waste, if these by-products can be well processed and utilized , can better save manpower and material resources, reduce environmental pollution, and leave precious resources

Method used

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  • Application of Zedoary turmeric oil in preparation of camphor and isolation and extraction method of Zedoary turmeric oil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Get the zedoary oil and put it into a vacuum precision fractionation device (such as figure 1 ) in the tower kettle, close the A, B, C, D, E pistons of the device, the heating temperature of the tower kettle is controlled at 180°C, the column height is 1.5m, the inner diameter of the column is 150mm, and the packing is made of 4mmx4mm stainless steel mesh, the number of theoretical plates >50, the reflux ratio is 6:1, use the D and E pistons to control the vacuum degree of the decompression precision fractionation device to make the vacuum degree in the device reach 800Pa, and the C piston is used to control the outflow of the buffer device. When the column temperature is 55°C, a solid-liquid mixture begins to flow out from the condenser. Open the A piston and start collecting this section of fraction. When the temperature rises to 63°C, the solid-liquid mixture flows out completely, and this section of fraction is collected. Close A. Piston, open the B piston, take out...

Embodiment 2

[0018] Take turmeric oil and put it in the tower kettle of the decompression precision fractionation device, close the A, B, C, D, E pistons of the device, control the heating temperature of the tower kettle at 220°C, the column height is 1.5m, and the inner diameter of the column is 150mm. Packing made of mesh, theoretical plate number > 50, reflux ratio of 6:1, vacuum degree of 900Pa, when the column temperature is 65°C, a solid-liquid mixture begins to flow out from the condenser, open the A piston, and start to collect this section Distillate, until 72 ° C, the solid-liquid mixture flows out completely, and the fraction of this section is collected. Close the A piston, open the B piston, take out this fraction and filter, the filtered solid is washed several times with petroleum ether, and then recrystallized with 8 times the volume of ether-petroleum ether (2:11v / v) to obtain white crystal camphor , it is 93% to detect camphor content with gas chromatograph.

Embodiment 3

[0020] Take zedoary oil and put it in the tower kettle of the decompression precision fractionation device, close the A, B, C, D, E pistons of the device, control the heating temperature of the tower kettle at 240 °C, the column height is 1.5m, the column inner diameter is 150mm, and the column is made of 4mmx4mm stainless steel Packing made of mesh, theoretical plate number > 50, reflux ratio of 6:1, vacuum degree of 1000Pa, when the column temperature is 72°C, a solid-liquid mixture begins to flow out from the condenser, open the A piston, and start to collect this section Distillate, until 80 ° C, the solid-liquid mixture flows out completely, and the fraction of this section is collected. Close the A piston, open the B piston, take out the fraction and filter, the filtered solid is washed several times with petroleum ether, and then recrystallized with 6 times the volume of absolute ethanol to obtain white crystal camphor, and the content of camphor is detected by gas chrom...

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Abstract

Application of Zedoary turmeric oil in the preparation of camphor and isolation and extraction method of the Zedoary turmeric oil are provided. Zedoary turmeric oil is added to a column bottom of a vacuum precision fractionation device and is subjected to vacuum precision fractionation under vacuum condition, a fraction with column temperature of 30-110 DEG C is collected, and the fraction is filtered and recrystallized to obtain camphor. It is the first time herein to extract camphor from Zedoary turmeric oil of the zingiberaceous plant Curcuma zedoaria, and the source range of natural camphor is widened. Byproducts of Zedoary turmeric oil in industrial production are made full use, resources are saved, manpower and material resources are decreased, and environmental pollution is zero. The camphor prepared herein by vacuum precision fractionation is 90 and above, the preparation method is simple, highly operable and easily industrializable; the invention is significant to clinical development of raw drugs or new preparations.

Description

technical field [0001] The invention belongs to the technical field of extraction of effective components of traditional Chinese medicines, and in particular relates to a method for extracting and preparing camphor from zedoary oil, a kind of volatile oil of traditional Chinese medicines. Background technique [0002] Camphor has the functions of dehumidifying and killing insects, warming and relieving pain, and resuscitating and eliminating pollution. It can be widely used in the fields of chemical industry, medicine, daily necessities, etc. It is also the main raw material for the production of borneonitrile and borneolate. Camphor is mainly extracted from Lauraceae plants such as Cinnamomum camphora leaves. In the prior art, the extraction method of natural camphor has harsh conditions and needs to be carried out at ultra-low temperature (-33~-78°C), making it difficult to realize industrial production. Chinese patent application 201510714006.X reports a method for refini...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C45/78C07C49/437
CPCC07C45/78C07C49/437
Inventor 徐文书梅冬雪杨友剑简卫光
Owner DALIAN DEZE PHARMA CO LTD
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