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Adenosine triphosphate disodium tablet and preparation method thereof

A technology of disodium adenosine triphosphate tablets and disodium adenosine triphosphate, which is applied in chemical instruments and methods, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of unsteady dissolution and other problems, and achieve easy stirring dead angle and stability in use Good, simple structure effect

Inactive Publication Date: 2017-05-10
南京康凯生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing adenosine triphosphate disodium tablets all adopt dry compression technology or adopt methods such as inclusion to increase the stability of the preparation, the dissolution is unstable, and clinically patients often have some side effects when taking it

Method used

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  • Adenosine triphosphate disodium tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Weigh 10 g of adenosine triphosphate disodium, 25 g of hydroxypropyl methylcellulose, 35 g of L-methionine, 20 g of calcium carbonate, 15 g of guar gum, 15 g of alginic acid, and 2 g of magnesium stearate.

[0017] Preparation process: put the adenosine triphosphate disodium raw drug in a crushing equipment and pulverize it; mix the pulverized adenosine triphosphate disodium raw material with the above-mentioned excipients in a particle mixer according to the amount, granulate according to the conventional method, compress into tablets, and enteric-coated , the finished product is packaged.

[0018] Particle mixers above, see figure 1 , including a base 1, a mixing cylinder 2 arranged on the base 1, a stirring motor 3 is arranged in the base 1, the main shaft of the stirring motor 3 is in contact with the center of the bottom wall of the mixing cylinder 2 Connected, the bottom wall in the mixing cylinder 2 is provided with a stirring pole 4, and at least two cavities 5...

Embodiment 2

[0022] Weigh 5 g of adenosine triphosphate disodium, 30 g of hydroxypropyl methylcellulose, 30 g of L-methionine, 30 g of calcium carbonate, 5 g of guar gum, 25 g of alginic acid, and 0.5 g of magnesium stearate.

[0023] The preparation process is the same as above.

Embodiment 3

[0025] Weigh 15 g of adenosine triphosphate disodium, 20 g of hydroxypropyl methylcellulose, 40 g of L-methionine, 10 g of calcium carbonate, 25 g of guar gum, 20 g of alginic acid, and 3.0 g of magnesium stearate.

[0026] The preparation process is the same as above.

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Abstract

The invention relates to adenosine triphosphate disodium, and belongs to the technical field of preparation of western medicines. The adenosine triphosphate disodium tablet consists of the following ingredients in parts by weight: 5-15 parts of adenosine triphosphate disodium, 20-40 parts of hydroxypropyl methylcellulose, 30-50 parts of L-methionine and the like. The ingredients are mixed by a specific particle stirrer; and the tablet is enteric coated and is slowly released stably.

Description

technical field [0001] The invention belongs to the technical field of western medicine preparations, in particular to an adenosine triphosphate disodium tablet. Background technique [0002] Adenosine triphosphate disodium tablets are indicated for the adjuvant treatment of progressive muscular atrophy, sequelae of cerebral hemorrhage, cardiac insufficiency, myocardial disease and hepatitis. Existing adenosine triphosphate disodium tablets all adopt the dry compression process or use methods such as inclusion to increase the stability of the preparation, and the dissolution is unstable, and some side effects are often produced when patients take it clinically. Contents of the invention [0003] In order to overcome the deficiencies of the prior art, the present invention provides a disodium adenosine triphosphate tablet through a large number of tests on auxiliary material screening, process optimization and equipment improvement. The tablet is sustained-release, has sma...

Claims

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Application Information

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IPC IPC(8): A61K9/28A61K31/7076B01F7/16A61P21/00A61P9/10A61P7/04A61P9/00A61P1/16
CPCA61K9/2054A61K9/2806A61K31/7076B01F27/191B01F27/85
Inventor 时贞平
Owner 南京康凯生物科技有限公司