A traditional Chinese medicine composition for preventing and treating cognitive impairment in diabetes and its preparation method

Abstract

The invention relates to a traditional Chinese medicine composition for preventing and treating cognitive disorder caused by diabetes mellitus, and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw material medicines: 20-26 parts of radix astragali seu hedysari, 8-11 parts of radix polygoni multiflori preparata, 8-11 parts of stir-fried fructus alpiniae oxyphyllae, 8-11 parts of herba epimedii, 4-7 parts of male silkworm moth, 8-10 parts of radix rehmanniae preparata, 13-17 parts of radix salviae miltiorrhizae, 2-5 parts of processed radix polygalae and 1-3 parts of rhizoma coptidis. The preparation method comprises the following steps: (1) distilling the stir-fried fructus alpiniae oxyphyllae and extracting volatile oil; (2) carrying out reflux extraction on the radix polygoni multiflori preparata and the rhizoma coptidis by using ethanol; (3) carrying out reflux extraction on the male silkworm moth and the radix salviae miltiorrhizae by using ethanol; (4) decocting the raw material medicines including the radix astragali seu hedysari, the herba epimedii, the radix rehmanniae preparata and the processed radix polygalae together with medicine residue obtained in the step (2); (5) merging water and liquid and concentrating, adding ethanol for extracting concentrated liquor, and concentrating again to obtain thick paste; (6) adding soluble starch to prepare granules, drying, spraying the volatile oil of the stir-fried fructus alpiniae oxyphyllae, evenly mixing, and placing in a closed environment. Pharmacological experiments prove that the traditional Chinese medicine composition is reasonable in formula, remarkable in effects and obvious in curative effect, and has the obvious functions of reducing blood glucose and improving the cognitive disorder caused by diabetes mellitus type 2.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for preventing and treating diabetic cognitive impairment, a preparation method and application thereof. It belongs to the field of traditional Chinese medicine technology and traditional Chinese medicine treatment. Background technique [0002] Diabetes is a metabolic disorder syndrome characterized by hyperglycemia, and its incidence is increasing year by year. According to statistics from the International Diabetes Federation in 2013, the global prevalence of diabetes among adults aged 20 to 79 was 8.3%, and the number of patients reached 382 million; the number of people with diabetes in China was 98.4 million, ranking first in the world. With the increasing number of diabetic patients year by year, the cognitive impairment caused by it has become a concern. Cognitive impairment refers to the pathological process in which the brain's advanced intelligence processing process relat...

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Problems solved by technology

Syndrome differentiation is mostly marrow sea deficiency, heart and spleen deficiency, kidney deficiency and blood stasis, and phlegm obstruction. Advantages of multi-channel and multi-target effects, but most of them are in the stage of experimental research, and no drugs have yet been launched on the market

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