Method and system for rapid calculation of pressure difference of bifurcated vessel and FFR based on CFD simulation

Abstract

The invention discloses a method for rapid calculation of a pressure difference of a bifurcated vessel and an FFR based on CFD simulation. The method comprises the following steps of receiving geometrical parameters and a geometrical model of a second of the bifurcated vessel, wherein the blood vessel comprises a near end point and a far end point and the geometrical parameters include a first geometrical parameter, a second geometrical parameter and a third geometrical parameter; receiving entrance blood flow volume and blood flow pressure at the near end point of the bifurcated vessel section; calculating a reference lumen diameter at a first position of the blood vessel based on the first geometrical parameter, the second geometrical parameter, the third geometrical parameter and the position data of the first position; utilizing computational fluid dynamics (CFD) simulation to obtain pressure distribution on the geometrical model based on the geometrical model and the entrance blood flow volume and the blood flow pressure at the near end point; and utilizing a pressure correction formula to correct the pressure distribution based on the first geometrical parameter and the third geometrical parameter, and computing to obtain a pressure difference value deltaP between first blood flow pressure at the near end point of the blood vessel and second blood flow pressure at the first position.

Description

technical field [0001] The invention is applied in the medical field, and in particular relates to a fast calculation method and system for blood vessel pressure difference and FFR obtained from computer fluid dynamics (CFD) simulation based on image correction. Background technique [0002] Conventional cardiovascular imaging techniques, such as coronary angiography, coronary CT angiography, and intraluminal imaging techniques, can image the anatomy of the coronary arteries and show the location and extent of vascular injury. Locating criminal blood vessels has certain limitations. Fractional flow reserve FFR can make up for the shortcomings of the above-mentioned imaging techniques, optimize the diagnosis of ischemic heart disease and the selection of criminal vessels, reduce unnecessary stent implantation, and improve the long-term therapeutic effect of patients. The gold standard for heart disease. [0003] FFR can be obtained by dividing the maximum myocardial blood f...

AI Technical Summary

Problems solved by technology

[0005] Although the above-mentioned existing technologies provide methods for determining blood vessel pressure drop from different angles and different calculation methods, they still have at least one or more of the following technical defects: (1) the use of pressure guide wires to intervene in blood vessels to collect blood vessels The geometric parameters are expensive and cause physical damage to the patient; (2) Although the single-scale calculation method can obtain the pressure drop in the case of conventional vascular stenosis, it cannot correctly distinguish and evaluate different degrees (such as limitation and Different Effects of Geometric Parameter Changes on Blood Flow Pressure under Stenosis of Diffuse Lesions

(3) Computer fluid dynamics (CFD) simulation based on the geometric model reconstructed by coronary angiography or CT, which has high computational complexity, large amount of calculation, and long time-consuming

(4) Relying on human assessment of lesion size, such as lesion length, has great subjectivity and error, especially for diffuse lesions

(5) It is necessary to use adenosine to induce the maximum coronary hyperemia to calculate the hyperemia blood flow velocity, which is complicated to operate and increases the pain of the patient

(6) It is necessary to carry out three-dimensional reconstruction of the branches of the diseased blood vessels, and the workload is heavy; (7) In the case of blood vessels with bifurcations, due to the change of the reference lumen area, the FFR cannot be accurately calculated

A frequently encountered problem in assessing the severity of bifurcation stenosis during revascularization is that it is difficult to determine the reference lumen of the vessel at the center of the bifurcation, thereby affecting the synthesis of stenosis from the proximal main vessel to the distal vessel. analyze

Tu Shengxian and others proposed to establish a new model, using a large number of curved elliptical planes to measure the bifurcation center, thus solving the ambiguity of determining the severity of the bifurcation center stenosis, but the accuracy is still limited

Generally, when reconstructing blood vessels in CFD simulation, all bifurcations need to be considered, which requires a heavy workload, and it is difficult to quickly calculate FFR. If only a single main vessel is considered in CFD simulation, other small points are ignored. Fork, the calculated pressure will be inaccurate, which will affect the accuracy of FFR

Images