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Decoquinate preparation as well as preparation method and application thereof

A technology for decoquinate and preparations, which is applied in the field of decoquinate preparations and its preparation, can solve problems such as high temperature, heating and melting, and decreased content of decoquinate, and achieve lower requirements, good dispersibility, and improved production efficiency effect

Active Publication Date: 2017-05-17
FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in this method, heating and melting are required, and the temperature is high, which easily causes the content of decoquinate to decline

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Weigh or measure appropriate amount of decoquinate, ethanol, polyvinylpyrrolidone K12, soybean lecithin and lactose respectively;

[0059] Simultaneously, the quality that makes decoquinate is 6% of the total mass of raw materials, the quality of ethanol is 5% of the total mass of raw materials, the quality of polyvinylpyrrolidone is 1% of the total mass of raw materials, and the quality of soybean lecithin is 1%. 1% of the total mass of auxiliary materials, and the balance is lactose;

[0060] Then, prepare decoquinate preparation according to the following steps:

[0061] (a) dissolving polyvinylpyrrolidone in ethanol, and completely dissolving polyvinylpyrrolidone to obtain a mixed solution;

[0062] (b) pulverizing the lactose until the particle size of the particles is below 80 mesh to obtain lactose powder;

[0063] (c) mixing decoquinate, soybean lecithin and part of lactose powder to obtain mixture A;

[0064] Wherein, the part of lactose powder is 30% of the...

Embodiment 2

[0068] Respectively weigh or measure an appropriate amount of decoquinate, ethanol-water solution (50% ethanol concentration), sodium carboxymethylcellulose, sorbitan monostearate and pregelatinized starch;

[0069] At the same time, the quality of decoquinate is 1% of the total mass of raw materials, the quality of ethanol-water solution is 3% of the total mass of raw materials, and the quality of sodium carboxymethyl cellulose is 0.5% of the total mass of raw materials. The quality of sorbitol monostearate is 0.3% of the total mass of raw and auxiliary materials, and the balance is pregelatinized starch;

[0070] Then, prepare decoquinate preparation according to the following steps:

[0071] (a) dissolving sodium carboxymethylcellulose in ethanol-water solution, and completely dissolving sodium carboxymethylcellulose to obtain a mixed solution;

[0072] (b) pulverizing the pregelatinized starch until the particle size is below 80 mesh; to obtain pulverized pregelatinized s...

Embodiment 3

[0078] Respectively weigh or measure an appropriate amount of decoquinate, ethanol, crospovidone, sorbitan trioleate and mannitol;

[0079] Simultaneously, the quality that makes decoquinate is 3% of the total mass of raw materials, the quality of ethanol is 5% of the total mass of raw materials, the quality of crospovidone is 2% of the total mass of raw materials, and sorbic acid trioleate The quality of Tan is 0.6% of the total mass of raw and auxiliary materials, and the balance is mannitol;

[0080] Then, prepare decoquinate preparation according to the following steps:

[0081] (a) dissolving the crospovidone in the ethanol-water solution, and completely dissolving the crospovidone to obtain a mixed solution;

[0082] (b) pulverizing the mannitol until the particle size is below 80 mesh to obtain mannitol powder;

[0083] (c) mixing decoquinate, sorbitan trioleate and part of mannitol powder to obtain mixture A;

[0084] Wherein, the part of mannitol powder is 30% of t...

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Abstract

The invention provides a decoquinate preparation as well as a preparation method and application thereof. According to the method provided by the invention, raw materials and auxiliary materials are low in price and a preparation process is simple; large-size high-end equipment is not needed and the decoquinate preparation can be relatively convenient and rapid to prepare; meanwhile, the prepared preparation has good dissolubility and dissolution. Meanwhile, in the preparation, decoquinate is matched with components including a wetting agent, a dispersant, a lipophilic surfactant, a soluble diluting agent and the like, so that tote dissolution of decoquinate can be effectively improved; furthermore, decoquinate can also be prepared into granules, tablets, dry suspension agents or premixing agents and meets the utilization requirements of different occasions; meanwhile, the decoquinate preparation can also be used for preparing medicines for treating coccus diseases and can achieve a good treatment effect.

Description

technical field [0001] The invention relates to the field of insecticide preparations, in particular to decoquinate preparations and their preparation methods and applications. Background technique [0002] Coccidiosis is an important disease of the poultry industry in the world and is caused by a variety of parasites of the genus Eimeria, including Eimeria acuminata, Eimeria brucei, Eimeria maxima, tenacious Eimeria, poisonous Eimeria and mutant Eimeria, etc. These parasites multiply in the intestinal epithelial cells, destroy the integrity of the intestinal mucosa, and reduce the digestion and absorption capacity of the intestine. In poultry, 6% to 10% of the mortality rate is caused by coccidiosis; at the same time, coccidiosis can also lead to the reduction of poultry growth rate and feed conversion rate, and the resulting global economic loss reaches billions of dollars every year. Dollar. [0003] At present, the prevention and treatment of coccidiosis is mainly bas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/47A61K47/26A61K47/36A61P33/02
CPCA61K9/00A61K31/47A61K47/26A61K47/36
Inventor 李成应焦伟丽徐奇清付良凯张庆
Owner FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
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