Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation method of enteral nutritional self-microemulsion

An enteral nutrition and self-microemulsion technology, applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc. question

Inactive Publication Date: 2017-05-24
安徽华明制药有限公司
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The particle size of submicroemulsion is between 100-1000nm, the appearance is opaque, turbid or milky, and its stability is not as good as that of nanoemulsion. Although it can be sterilized by autoclaving, if the sterilization time is too long or repeated sterilization, it will also Stratification, which belongs to the thermodynamically unstable system

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011] Implementation example 1:

[0012] The oil phase was added to the water phase at a speed of 10 ml / min under magnetic stirring, the temperature of the water phase was 35°, and the magnetic stirring was 500 r / min. Stir the two phases until the emulsion is transparent, and then continue to stir for 0.5h.

[0013] Implementation example 2:

[0014] The oil phase was added into the water phase at a speed of 20 ml / min under magnetic stirring, the temperature of the water phase was 45°, and the magnetic stirring was 500 r / min. Stir the two phases until the emulsion is transparent, and then continue to stir for 0.5h.

[0015] Implementation example 3:

[0016] The oil phase was added to the water phase at a speed of 30 ml / min under magnetic stirring, the temperature of the water phase was 55°, and the magnetic stirring was 500 r / min. Stir the two phases until the emulsion is transparent, and then continue to stir for 0.5 h.

[0017] The stability of the three samples prepa...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention provides a preparation method of an enteral nutritional self-microemulsion and discloses enteral nutritional composition. The enteral nutritional self-microemulsion is prepared from the components in percentage by mass as follows: 0.5%-5% of protein, 36%-61% of fat, vitamins, minerals, 8%-30% of an emulsifier and 5%-30% of a co-emulsifier. On one hand, the prepared enteral nutritional composition self-microemulsion can solve the problems of poor stability and large storage size due to larger particle size and presence of water phase of a traditional emulsion, on the other hand, solubility and dispersity of nutrients are improved, in-vivo absorption of a drug is promoted, and bioavailability is improved. The enteral nutritional self-microemulsion has the characteristics of low viscosity, stable quality and the like, facilitates improvement of drug absorption, improves the bioavailability and reduces toxic and side effects.

Description

technical field [0001] The invention relates to a nutritional energy supplement prepared as enteral nutrition self-microemulsion, which improves the stability of the product. Background technique [0002] The concept of microemulsion (microemulsion) was first proposed by Hoar-HSchulman in 1943. It is a transparent or translucent, low-viscosity, Isotropic and thermodynamically stable solution system. With the rapid development of nanotechnology, the development of new technologies and new dosage forms of microemulsions has been promoted, and the varieties of emulsions have been further enriched. Nanoemulsion (nanoemulsion) is a colloidal dispersion system formed by dispersing emulsion droplets with a particle size of 10-100nm in another liquid. The emulsion droplets are mostly spherical, relatively uniform in size, transparent or translucent, and can be sterilized by autoclaving or Centrifugation cannot make it stratified, and it is usually a thermodynamically stable system...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K45/06A61K31/715A61K38/00A61K47/44A61K47/34A61K47/12A61K47/10A61P3/02
Inventor 不公告发明人
Owner 安徽华明制药有限公司