Pharmaceutical preparation containing low molecular weight xanthan gum for intra-articular injection and preparation method of pharmaceutical preparation

A low molecular weight, pharmaceutical preparation technology, applied in the field of medicine, can solve the problems of difficult discharge, difficult enzyme and free radical degradation, etc., and achieve the effects of long action time, less product impurities and excellent safety.

Active Publication Date: 2017-05-24
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, xanthan gum with conventional molecular weight (relative molecular weight is 2 million to 20 million) is very stable, and

Method used

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  • Pharmaceutical preparation containing low molecular weight xanthan gum for intra-articular injection and preparation method of pharmaceutical preparation
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  • Pharmaceutical preparation containing low molecular weight xanthan gum for intra-articular injection and preparation method of pharmaceutical preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Preparation method of low molecular weight xanthan gum

[0023] Take 10 g of xanthan gum with a molecular weight of 3 million and dissolve it in 1000 ml of water for injection, add 50 g of sodium chloride and 50 mg of sodium EDTA, adjust the pH to 5, and stir at a speed of 50 rpm until fully dissolved. The solution was placed in a high-pressure reactor, the reaction pressure was 0.4 MPa, the reaction temperature was 75 °C, and the reaction time was 15 min. The sample was precipitated with 3000 ml of absolute ethanol, washed and dried to obtain a xanthan gum sample, and its concentration was detected by a multi-angle laser scatterer. Mw is 1.5 million.

Embodiment 2

[0024] Example 2 Preparation method of low molecular weight xanthan gum

[0025] Take 30 g of xanthan gum with a molecular weight of 3 million and dissolve it in 1000 ml of water for injection, add 30 g of sodium chloride and 100 mg of sodium EDTA, adjust the pH to 7, and stir at 100 rpm until fully dissolved. The solution was placed in a high-pressure reactor, the reaction pressure was 1 MPa, the reaction temperature was 100 °C, and the reaction time was 10 min. The sample was precipitated with 5000 ml of absolute ethanol, washed and dried to obtain a xanthan gum sample, and its Mw was detected by a multi-angle laser scatterer. to 1 million.

Embodiment 3

[0026] Example 3 Preparation method of low molecular weight xanthan gum

[0027] Take 100 g of xanthan gum with a molecular weight of 3 million and dissolve it in 1000 ml of water for injection, add 10 g of sodium chloride and 200 mg of sodium EDTA, adjust the pH to 10, and stir at a speed of 200 rpm until fully dissolved. The solution was placed in a high-pressure reactor, the reaction pressure was 1.6 MPa, the reaction temperature was 135 °C, and the reaction time was 25 min. The sample was precipitated with 7000 ml of absolute ethanol, washed and dried to obtain a xanthan gum sample, and its concentration was detected by a multi-angle laser scatterer. Mw is 200,000.

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Abstract

The invention discloses a pharmaceutical preparation containing low molecular weight xanthan gum for intra-articular injection. The pharmaceutical preparation contains the low molecular weight xanthan gum, has the relative molecular mass of 0.1-1.99million, has the content of 0.01-5% (w/v), and has an osmotic pressure of 200-400 mOsmol/L and a pH value of 5.5-9. The pharmaceutical preparation containing low molecular weight xanthan gum for intra-articular injection is obtained by the following preparation method: regulating the pH value of raw xanthan gum aqueous solution with the concentration of 1-10% and the relative molecular weight of 3 million to 5-10, adding the solution into a high-pressure reactor, stirring under a certain pressure and temperature for reacting, precipitating the product by using absolute ethyl alcohol, washing, drying so as to obtain the xanthan gum with the relative molecular mass of 0.1-1.99million; and uniformly mixing the xanthan gum and other components, thereby obtaining the preparation. The pharmaceutical preparation containing low molecular weight xanthan gum for intra-articular injection disclosed by the invention can be applied to improving and treating rheumatic arthritis, rheumatoid arthritis, osteoarthritis, synovitis and/or cartilage injury and has the advantages of long in-vivo retention time, capacity of being discharged out of the body through degradable and metabolic pathways and high safety.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical preparation containing low molecular weight xanthan gum for intra-articular injection and a preparation method. Background technique [0002] Osteoarthritis (OA) is a common inflammatory disease in joints such as fingers, hips, shoulders and knees, characterized by cartilage degradation and bone hyperplasia, accompanied by joint pain, limited movement, and severe disease Some patients even lose motor function, which seriously affects the daily life of patients. At present, the prevalence of primary osteoarthritis in different ages in my country is: 30.1% for 40 to 49 years old, 48.7% for 50 to 59 years old, 62.2% for 60 to 69 years old, and 62% for those over 70 years old. my country has become one of the countries with the largest number of OA patients in the world. OA has brought great pain and economic burden to middle-aged and elderly people, and has becom...

Claims

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Application Information

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IPC IPC(8): A61K31/723A61K9/06A61P19/02A61P29/00A61P19/04C08B37/00
CPCA61K9/0019A61K9/06A61K31/723A61K47/02C08B37/0033
Inventor 凌沛学刘飞韩冠英朱希强陈磊张晓元陈勉陈启鑫邵华荣程艳玲张建强张治云王勤
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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