Pharmaceutical preparation containing low molecular weight xanthan gum for intra-articular injection and preparation method of pharmaceutical preparation
A low molecular weight, pharmaceutical preparation technology, applied in the field of medicine, can solve the problems of difficult discharge, difficult enzyme and free radical degradation, etc., and achieve the effects of long action time, less product impurities and excellent safety.
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Embodiment 1
[0022] Example 1 Preparation method of low molecular weight xanthan gum
[0023] Take 10 g of xanthan gum with a molecular weight of 3 million and dissolve it in 1000 ml of water for injection, add 50 g of sodium chloride and 50 mg of sodium EDTA, adjust the pH to 5, and stir at a speed of 50 rpm until fully dissolved. The solution was placed in a high-pressure reactor, the reaction pressure was 0.4 MPa, the reaction temperature was 75 °C, and the reaction time was 15 min. The sample was precipitated with 3000 ml of absolute ethanol, washed and dried to obtain a xanthan gum sample, and its concentration was detected by a multi-angle laser scatterer. Mw is 1.5 million.
Embodiment 2
[0024] Example 2 Preparation method of low molecular weight xanthan gum
[0025] Take 30 g of xanthan gum with a molecular weight of 3 million and dissolve it in 1000 ml of water for injection, add 30 g of sodium chloride and 100 mg of sodium EDTA, adjust the pH to 7, and stir at 100 rpm until fully dissolved. The solution was placed in a high-pressure reactor, the reaction pressure was 1 MPa, the reaction temperature was 100 °C, and the reaction time was 10 min. The sample was precipitated with 5000 ml of absolute ethanol, washed and dried to obtain a xanthan gum sample, and its Mw was detected by a multi-angle laser scatterer. to 1 million.
Embodiment 3
[0026] Example 3 Preparation method of low molecular weight xanthan gum
[0027] Take 100 g of xanthan gum with a molecular weight of 3 million and dissolve it in 1000 ml of water for injection, add 10 g of sodium chloride and 200 mg of sodium EDTA, adjust the pH to 10, and stir at a speed of 200 rpm until fully dissolved. The solution was placed in a high-pressure reactor, the reaction pressure was 1.6 MPa, the reaction temperature was 135 °C, and the reaction time was 25 min. The sample was precipitated with 7000 ml of absolute ethanol, washed and dried to obtain a xanthan gum sample, and its concentration was detected by a multi-angle laser scatterer. Mw is 200,000.
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