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Dual-computer injectable in-situ functional hydrogel biomaterial and preparation method thereof

A biomaterial, injection-type technology, used in tissue regeneration, non-active components of polymer compounds, medical preparations with non-active components, etc., can solve problems such as poor stability and weak mechanical properties, and achieve easy industrial production and preparation methods. Simple, broad-spectrum effects

Inactive Publication Date: 2017-05-24
广州永翔科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Physical cross-linking is mainly formed by intermolecular interactions (van der Waals force, hydrophobic interaction, charge interaction, hydrogen bond, etc.). This type of gel is simpler and safer to use because it does not involve chemical reactions in the formation process. The mechanical properties are also weak and the stability is poor

Method used

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  • Dual-computer injectable in-situ functional hydrogel biomaterial and preparation method thereof
  • Dual-computer injectable in-situ functional hydrogel biomaterial and preparation method thereof
  • Dual-computer injectable in-situ functional hydrogel biomaterial and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0024] 3.0g polyethylene glycol (PEG 1500 -SCM 2 ) was dissolved in 0.1M pH 7.4 PBS buffer solution, and its mass fraction was controlled between 5% and 15%, which was set as component one; 1.0g polylysine (ε-PL) was dissolved in 0.1M pH 7.4 PBS buffer solution, whose mass fraction is controlled between 1% and 10%, is set as component 2; then component 1 and component 2 are respectively loaded into a two-component mixing syringe, and the double component can be prepared by rapid mixing. Component injectable in situ functional hydrogel biomaterials. The product is obtained after sterilization and packaging.

Embodiment 2

[0026] 1.0g four-arm-polyethylene glycol (4-arm-PEG-SCM 4 , see NMR spectrum figure 1 ) was dissolved in 0.1M PBS buffer solution with pH 7.4, and its mass fraction was controlled between 5% and 15%, which was set as component one; 0.8g polylysine (ε-PL, see figure 2 ) was dissolved in 0.1M pH 7.4 PBS buffer solution, and its mass fraction was controlled between 1% and 10%, which was set as component two; then component one and component two were respectively loaded into two-component mixing syringes, passed This two-component injectable in situ functional hydrogel biomaterial can be prepared by rapid mixing. The product is obtained after sterilization and packaging.

Embodiment 3

[0028] 1.8g eight-arm-polyethylene glycol (8-arm-PEG-SCM 8 ) was dissolved in deionized water, and its mass fraction was controlled between 5% and 15%, which was set as component one; 0.2g amino-modified collagen (Collagen-NH 2 ) was dissolved in deionized water, and its mass fraction was controlled between 1% and 3%, and it was set as component two; then component one and component two were respectively loaded into two-component mixing syringes, and the mixture could be mixed quickly The two-component injectable in-situ functional hydrogel biological material is prepared, and the product is obtained after sterilization and packaging.

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Abstract

The invention belongs to the field of biomaterials, and particularly relates to a dual-component injectable in-situ functional hydrogel biomaterial and a preparation method thereof. According to the method, terminal functionalized polyether polymer is used as a first component, amino functionalized macromolecules are used as a second component, the two components are uniformly mixed with a dual-component injector to prepare the dual-component injectable in-situ functional hydrogel biomaterial. The preparation method is simple and quick, and can easily realize industrial production; and the prepared hydrogel is convenient to use, has good biocompatibility, is completely nontoxic and harmless to human bodies, and can be widely applied to the fields of tissue engineering, drug controlled release materials, wound dressing and the like.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a two-component injectable in-situ functional hydrogel biological material and a preparation method thereof. Background technique [0002] Hydrogels are insoluble in water, but can swell in water. Due to their high water content, excellent swelling properties, good biocompatibility, high permeability and 3D network structure, they are widely used in tissue engineering, wound repair and fields of regenerative medicine. In recent years, injectable hydrogels have become an important research field and have attracted extensive attention from all walks of life. Compared with ordinary gels, it has the following advantages: (1) It can be gelled quickly, can be filled in any shape, and can be used flexibly; (2) It can be used by injection, so that the trauma is less and the pain of patients is reduced; (3) It can be used Uniformly encapsulates various biologically active...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/20A61L27/24A61L27/52A61L26/00A61L24/00A61L24/08A61L24/10A61K47/34A61K47/36A61K47/42
CPCA61L27/18A61K47/34A61K47/36A61K47/42A61L24/0031A61L24/046A61L24/08A61L24/102A61L26/0019A61L26/0023A61L26/0033A61L26/008A61L27/20A61L27/24A61L27/52A61L2400/04A61L2400/06A61L2430/02A61L2430/22C08L89/00C08L71/02C08L5/08C08L77/04
Inventor 赵鹏吴亮亮刘静张浩文学军
Owner 广州永翔科技发展有限公司