Fully automatic plasma processing equipment and processing method

A plasma processing, fully automatic technology, applied in peptide preparation methods, chemical instruments and methods, peptides, etc., can solve the problems of poor reproducibility, human error in feeding, lack of storage space, etc., to improve recovery and yield , reduce production costs, reduce the effect of problem products

Active Publication Date: 2020-03-20
CHANGSHU NANOMICRO BIOTECHNOLOGY CO LTD
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Problems solved by technology

[0002] In the traditional plasma treatment scheme, it is often necessary to use a large (10,000 liter) buffer tank, but the storage space of the large buffer tank is insufficient, it is difficult to prepare a 10,000L batch of treatment solution in the large buffer tank, and the feeding is human error, mixing The variability of the treatment methods is endless, the acidity and ionic strength are not easy to control, and the ethanol concentration, conductivity and pH fluctuations cannot be completely controlled, which directly affects the solubility of proteins in plasma, resulting in unsatisfactory yield and purity.
However, if the manual method is adopted, the labor production cost is very high, and the reproducibility is poor

Method used

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  • Fully automatic plasma processing equipment and processing method
  • Fully automatic plasma processing equipment and processing method
  • Fully automatic plasma processing equipment and processing method

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Embodiment Construction

[0032] In view of the deficiencies in the prior art, the inventor of this case was able to propose the technical solution of the present invention after long-term research and extensive practice. The technical solution, its implementation process and principle will be further explained in conjunction with the accompanying drawings and embodiments as follows. However, it should be understood that within the scope of the present invention, the above-mentioned technical features of the present invention and the technical features specifically described in the following (such as embodiments) can be combined with each other to form new or preferred technical solutions. Due to space limitations, we will not repeat them here.

[0033] In a typical embodiment of the present invention, a fully automatic plasma processing equipment is provided, which includes:

[0034] pH pump for transporting pH adjustment solution;

[0035] Acetic acid pump for conveying acetic acid;

[0036] Ethan...

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Abstract

The invention discloses a full-automatic plasma processing equipment and method. The equipment comprises a pH pump, an acetic acid pump, an ethanol pump, a plasma pump, a plasma precipitation reaction pool, a buffer solution circulating pump, a buffer solution trap, a buffer solution tank, a three-way valve and a feedback control system; the pH pump, the acetic acid pump and the ethanol pump are communicated with the buffer solution trap and the buffer solution tank respectively through a first mixer, the feedback control system is arranged between the buffer solution trap and the buffer solution tank, and the feedback control system is electrically connected with the pH pump, the acetic acid pump and the ethanol pump; the first port of the three-way valve is communicated with the buffer solution tank, the second port of the three-way valve is communicated with the plasma precipitation reaction pool, the third port of the three-way valve is communicated with the buffer solution circulating pump, and the buffer solution circulating pump and the plasma pump are communicated with the buffer solution tank through a second mixer. Accordingly, full automation can be achieved, the conductivity, ethanol concentration and acidity and alkalinity of a buffer solution are accurately controlled, protein in the plasma is precipitated through online verification, the recovery rate and yield of the plasma protein can be increased, and profit rate is increased.

Description

technical field [0001] The invention relates to a fully automatic plasma processing device, in particular to a fully automatic plasma processing device and a method for processing plasma using the device, belonging to the technical field of plasma processing equipment. Background technique [0002] In the traditional plasma treatment scheme, it is often necessary to use a large (10,000 liter) buffer tank, but the storage space of the large buffer tank is insufficient, it is difficult to prepare a 10,000L batch of treatment solution in the large buffer tank, and the feeding is human error, mixing The variability of treatment methods such as proscriptions is endless, acidity and ionic strength are not easy to control, and ethanol concentration, conductivity and pH fluctuations cannot be fully controlled, thereby directly affecting the solubility of proteins in plasma, resulting in unsatisfactory yield and purity. However, if the manual method is adopted, the labor production c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K1/30C07K1/14
CPCC07K1/14C07K1/30
Inventor 李国荣
Owner CHANGSHU NANOMICRO BIOTECHNOLOGY CO LTD
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