Artificial lung and artificial heart-lung circuit device
A technology of artificial lung and gas exchanger, applied in the direction of medicine equipment, other medical equipment, suction equipment, etc., can solve the problem of gas exchange performance, heat exchange performance deterioration, increase blood pressure loss, increase blood cell damage And other issues
Inactive Publication Date: 2017-05-24
TERUMO KK
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Problems solved by technology
[0007] However, if the surface area of the hollow fiber membrane for gas exchange and the unit for heat exchange are reduced, the gas exchange performance and heat exchange performance will be deteriorated, respectively.
If hollow fiber membranes for gas exchange and units for heat exchange are densely installed, the pressure loss on the blood side may increase and the amount of blood cell damage may increase.
Method used
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Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1～3
[0118] In Examples 1 to 3, in order to design an artificial lung having a performance factor Fp superior to the performance factor Fp of the currently commercially available artificial lung shown in Table 1, the following improvements were made to the gas exchanger part and the heat exchanger part Designed and implemented.
[0119] The hollow fiber for gas exchange was made into a small diameter, and the arrangement|positioning of the hollow fiber membrane bundle was examined. In addition, the unit for heat exchange uses resin tubes for heat exchange, and its material and heat transfer area are adjusted, and the arrangement of resin tubes for heat exchange is considered. The details are listed in Table 6.
[0120] The blood filling volume of the whole artificial lung is preferably 200 mL or less, and more preferably designed to be 190 mL or less. The blood filling volume of only the gas exchanger is preferably 65 mL or less, more preferably designed to be 60 mL or less.
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The purpose of the present invention is to provide a technology with which the performance of components of an artificial lung can be examined in a unified manner and with which the artificial lung, which is capable of exhibiting a comprehensively excellent performance, is designed and evaluated. Provided is an artificial lung which comprises a gas exchanger unit having an external perfusion-type hollow fibre membrane bundle for gas exchange and comprises a heat exchanger unit having heat exchange elements. The artificial lung measures gas exchange performance, a heat exchange performance coefficient, the amount of blood filled, and blood-side pressure loss and calculates Fp = (gas exchange performance * heat exchange performance coefficient) / (amount of blood filled * blood-side pressure loss). The value of Fp is 1.5-2.5.
Description
technical field [0001] The present invention relates to the design or performance evaluation technology of artificial lung. Background technique [0002] An artificial lung is an artificial organ that supplies oxygen to the blood and removes carbon dioxide from the blood, which is one of the functions of a biological lung. Currently, the external perfusion type using hollow fiber membranes is the mainstream. It is mainly used to form an extracorporeal circulation circuit instead of a biological lung for several hours during an operation on the heart performed by stopping the beating heart, so-called open heart surgery. In addition, it is also used as a breathing assistance device and a percutaneous cardiopulmonary assist device for patients with acute lung failure and heart failure. [0003] In the artificial lung used for extracorporeal circulation of blood, since the blood is exported outside the patient's body and loses heat, it is necessary to restore the blood to a te...
Claims
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IPC IPC(8): A61M1/18A61M1/14
CPCA61M1/3666A61M2207/00A61M1/1621A61M1/3606A61M1/1629A61M1/1698A61M2205/3331A61M2205/3379A61M1/3623
Inventor 斋藤乔佐佐木瑛祐
Owner TERUMO KK