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Preparation method for multifunctional medicine elution coating for intravascular stent

A vascular stent and drug coating technology, applied in the fields of coating, medical science, surgery, etc., can solve the problems of chronic inflammation, neo-atherosclerosis, delayed endothelial healing, etc., to reduce the incidence of thrombosis and reduce inflammation effect of reaction

Active Publication Date: 2017-05-31
GUANGZHOU NANCHUANG EVEREST MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The implantation of drug-eluting stents (DES) reduces the restenosis rate from 30% of bare metal stents to less than 10%. endothelial cell growth, resulting in delayed endothelial healing; neoatherosclerosis, drug-eluting stent implantation also presents acute and chronic inflammatory responses

Method used

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  • Preparation method for multifunctional medicine elution coating for intravascular stent
  • Preparation method for multifunctional medicine elution coating for intravascular stent
  • Preparation method for multifunctional medicine elution coating for intravascular stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Prepare a solution of the following ingredients:

[0021]

[0022] The above mixed system was stirred and dispersed at 50 rpm to form a solution.

[0023] Place the cleaned stent on the stent movement axis of the ultrasonic atomization spraying system, the ultrasonic power is 2W, the solution flow rate is 2.00ml / min, and the number of sprays is 10 times, then the sprayed stent is dried at room temperature for 18 hours, and then Vacuum dry in a vacuum oven at 30° C. for 12 hours, and the coating thickness is about 5 microns.

Embodiment 2

[0025] Prepare a solution of the following ingredients:

[0026]

[0027] The above mixed system was stirred and dispersed at a speed of 300 rpm to form a solution.

[0028] Place the cleaned stent on the stent movement axis of the ultrasonic atomization spraying system, the ultrasonic power is 10W, the solution flow rate is 0.50ml / min, and the number of sprays is 20 times, then the sprayed stent is dried at room temperature for 12 hours, and then Vacuum dry in a vacuum oven at 20° C. for 10 hours, and the coating thickness is about 3 microns.

Embodiment 3

[0030] Prepare a solution (for drug coating) of the following ingredients:

[0031]

[0032] The above mixed system was stirred and dispersed at a speed of 500 rpm to form a solution.

[0033] Place the cleaned stent on the stent movement axis of the ultrasonic atomization spraying system, the ultrasonic power is 5W, the solution flow rate is 1.00ml / min, and the number of sprays is 30 times, then the sprayed stent is dried at room temperature for 24 hours, and then Vacuum dry in a vacuum oven at 25° C. for 24 hours, and the coating thickness is about 10 microns. The stent coating is observed under a microscope and an electron microscope. The stent has a good appearance before and after the stent is stretched.

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Abstract

The invention discloses a preparation method for a multifunctional medicine elution coating for an intravascular stent. The preparation method comprises the steps of putting 9.8 to 30 percent of degradable polymer carriers, 0.2 to 20 percent of medicine A and medicine B and 50 to 90 percent of solvents in percentage by weight into a container; performing stirring and dispersion into a solution by a rotating speed of 50 to 1000 rpm; uniformly spraying the solution onto the support frame surface by an ultrasonic atomization spray coating method; performing drying for 12 to 48 hours at a room temperature; then, performing vacuum drying for 10 to 72 hours in a vacuum drying box at 25 to 85 DEG C. The medicine coating prepared by the method has the advantages that the simultaneous loading of the two kinds of medicine of statins medicine and polyphenols medicine is realized; the multiplication and the migration of smooth muscle cells are inhibited through the controlled release of the carried medicine; the endothelial cell multiplication is promoted; the fast endothelialization is realized; the effect of resisting thrombus formation and stabilizing or reversing new atherosclerosis is achieved; the occurrence of stent late thrombosis is reduced.

Description

technical field [0001] The invention belongs to the field of cardiovascular interventional treatment devices, and more specifically relates to a preparation method of a multifunctional drug-eluting coating for vascular stents. Background technique [0002] Coronary heart disease is a high incidence of human diseases. The effective means of treating coronary heart disease is the implantation of vascular stents. In China alone, more than 700,000 vascular stents are clinically used every year. The implantation of drug-eluting stents (DES) reduces the restenosis rate from 30% of bare metal stents to less than 10%. The growth of endothelial cells is inhibited, resulting in delayed endothelial healing; new atherosclerosis, drug-eluting stent implantation also has acute and chronic inflammatory responses. Endothelial delay, inflammatory response, and in-stent neoatherosclerosis are important causes of in-stent restenosis and late-stage in-stent thrombosis after implantation of dru...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/16A61L31/14A61L31/10
CPCA61L31/10A61L31/14A61L31/16A61L2300/42A61L2300/422A61L2300/606A61L2300/802A61L2420/06C08L67/04C08L35/00C08L69/00
Inventor 王进谢灵霞李欣黄楠李娜
Owner GUANGZHOU NANCHUANG EVEREST MEDICAL TECH CO LTD
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