Phase-detection optical fiber SPR (Surface Plasmon Resonance) biochemical sensing system

A sensing system and phase detection technology, applied in the field of SPR principles, can solve problems such as low stability, limitations, and large volume, and achieve the effects of low cost, good stability, and high resolution

Inactive Publication Date: 2017-05-31
DALIAN UNIV OF TECH
View PDF10 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, phase-detection SPR sensors are usually combined with prism sensing elements and require an interference optical path. Therefore, they are large in size, low in stability, and expensive in production costs. Most of them are limited to laboratory research and cannot be widely used in industrial production.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Phase-detection optical fiber SPR (Surface Plasmon Resonance) biochemical sensing system
  • Phase-detection optical fiber SPR (Surface Plasmon Resonance) biochemical sensing system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0013] 1. Preparation process

[0014] 1) The side of the multi-dual-core optical fiber is treated with microstructure by grinding technology, and the side of the bent optical fiber is ground into a plane, so that the core is exposed;

[0015] 2) Depositing a gold film with a thickness of 50nm on the surface of the exposed fiber core by magnetron sputtering technology;

[0016] 3) Connect the two points of the processed dual-core fiber to the single-mode fiber respectively, one end to the light source, and the other end to the collimator lens;

[0017] 4) Pass the light emitted by the collimating lens through the Wollaston prism, and receive it by the photodetector;

[0018] 5) Connect the photodetector to the computer with a USB data cable;

[0019] 2. Operation

[0020] 1) Encapsulate the sensing element in the flow cell, keep it sealed, and reduce the volatilization of experimental samples;

[0021] 2) The sensing element is connected with the light source and the colli...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a phase-detection optical fiber SPR (Surface Plasmon Resonance) biochemical sensing system, and belongs to the technical field of optical fiber sensing biochemical detection. An SPR phase detection technology is combined with an optical sensing technology to realize a high-resolution, low-cost and small-sized SPR biochemical detection function. According to the technical scheme, an SPR detection signal and a Mach-Zehnder interference signal are provided by taking a dual-core optical fiber of which the side face is ground and on which a gold membrane is deposited, laser is taken as a light source, a single-mode optical fiber is used for transmitting light, a photoelectric detector is taken as a receiving device of optical signals, and LabVIEW software is used for acquiring, processing and storing data. The resolution of the sensing system can be increased through detection of an SPR signal in a phase detection way, and the size of the sensing system can be reduced by an optical fiber sensing element, so that low-cost, convenient, rapid, high-resolution and low-concentration biochemical sample detection analysis can be realized.

Description

technical field [0001] The invention belongs to the technical field of optical fiber sensing biochemical detection, uses a high-resolution surface plasmon resonance (SPR) phase detection method combined with a portable dual-core optical fiber sensing element, and relates to the SPR principle. The structure of the whole system is simple. Through the combination of SPR phase detection technology and optical fiber sensing technology, a high-sensitivity, high-resolution miniaturized SPR biochemical system can be realized, and specific detection of micro-concentration protein samples can be realized. It has broad application prospects in medical and other detection fields. Background technique [0002] Surface Plasmon Resonance (SPR) is a new photoelectric detection technology in recent years. It is a physical phenomenon that applies light wave transmission and electromagnetic wave excitation. When the light transmitted in the prism or waveguide is coupled into the metal film, a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): G01N21/41
CPCG01N21/41G01N21/553G01N21/4133
Inventor 彭伟陈诗蒙刘云
Owner DALIAN UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap