A method for screening and functional analysis of oncogenes related to non-small cell lung cancer

A non-small cell lung cancer and functional analysis technology, which is applied in the field of non-small cell lung cancer-related oncogene screening and functional analysis based on big data, can solve the problems that hinder the research process of the molecular mechanism of the disease, and the data information is not fully utilized.
CN106778066BActive Publication Date: 2019-02-15THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
Publication Date
2019-02-15

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Abstract

The invention discloses a method for screening and functionally analyzing related oncogenes of non-small-cell lung cancer. The method includes steps of searching mRNA [messenger RNA (ribonucleic acid)] expression chip results related to the NSCLC (non-small-cell lung cancer) from GEO (gene expression omnibus) databases http: / / www.ncbi.nlm.nich.gov / geo / and acquiring mRNA expression results by the aid of GEO2R databases; searching identical mRNA gene expression results in two research results by the aid of Venn diagrams; functionally analyzing gene enrichment by the aid of bioinformatics technologies. The method has the advantages that mRNA differential expression genes are downloaded by the aid of the diversified online databases, the common differential expression genes in different research series are searched and are subjected to bioinformatics analysis, and accordingly significant exploration and bases can be provided for tumor marker screening, molecular pathogenesis and the like of the NSCLC.
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Description

technical field

[0001] The invention belongs to the field of biotechnology, and relates to a method for screening and functional analysis of oncogenes related to non-small cell lung cancer, in particular to a method for screening and functional analysis of oncogenes related to non-small cell lung cancer based on big data. Background technique

[0002] Lung cancer is a malignant tumor with the highest morbidity and mortality in China and the world. In the past 40 years, the 5-year survival rate of lung cancer has only increased from 12% to 16%. The main reason is that it is diagnosed at an advanced stage. On the contrary, the survival rate of early-diagnosed lung cancer can be increased to 80% after surgery. It can be seen that early detection and early diagnosis have important clinical significance for the treatment and prognosis of lung cancer. Currently widely used detection methods include non-invasive examinations (such as X-ray, CT, mammography, etc.) possibility of w...

Claims

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