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A preparation method of acid etching modified microfluidic paper chip

A microfluidic paper chip, acid etching technology, applied in chemical instruments and methods, laboratory containers, laboratory utensils, etc., can solve the problems of poor reproducibility and stability, increased production costs, channel viscosity, etc. High problems, to achieve the effect of easy large-scale industrial production, high stability, and low environmental pollution

Active Publication Date: 2019-05-10
HUNAN NORMAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the literature reports mainly use wax printing, inkjet printing, photolithography, laser etching or plasma treatment to construct hydrophilic and hydrophobic regions to prepare paper chips. The disadvantages of this method are the high viscosity, reproducibility and stability of the constructed channels. It is not good and the pattern form is limited. At the same time, it needs relatively expensive instruments and professional personnel to use and maintain, which increases the production cost to a large extent, so it cannot be applied to all patterns.
At present, advanced technology has been developed to avoid the need for special instruments and reagents, the leakage of plasma gas and the yellowing of paper caused by ultraviolet light, but there is no report on the preparation of microfluidic paper chips by acid etching.

Method used

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  • A preparation method of acid etching modified microfluidic paper chip
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Experimental program
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Effect test

Embodiment 1

[0020] (1) Preparation of superhydrophobic filter paper: according to the existing silanized paper modification technology, superhydrophobic filter paper with a contact angle of 140°~150° was prepared;

[0021] Soak the filter paper with octadecyltrichlorosilane-n-hexane solution with a volume fraction of 0.1%, ultrasonically react for 5 min, rinse with n-hexane, ethanol, and distilled water three times after taking out the tweezers, and let it dry naturally at room temperature. superhydrophobic filter paper;

[0022] (2) Fabrication of the filter paper mask: on the ordinary chromatography qualitative analysis filter paper, the channel configuration of different patterns is designed by drawing software, and the filter paper mask is obtained after manual processing;

[0023] (3) Partial hydrophilic modification of superhydrophobic filter paper: Soak the filter paper mask prepared in step (2) in 1 mol / L hydrochloric acid solution, take it out after soaking completely, and cover ...

Embodiment 2

[0027] (1) Preparation of superhydrophobic filter paper: according to the existing silanized paper modification technology, superhydrophobic filter paper with a contact angle of 140°~150° was prepared;

[0028] Soak the filter paper with octadecyltrichlorosilane-n-hexane solution with a volume fraction of 0.1%, ultrasonically react for 5 min, rinse with n-hexane, ethanol, and distilled water three times after taking out the tweezers, and let it dry naturally at room temperature. superhydrophobic filter paper;

[0029] (2) Fabrication of the filter paper mask: on the ordinary chromatography qualitative analysis filter paper, the channel configuration of different patterns is designed by drawing software, and the filter paper mask is obtained after manual processing;

[0030] (3) Partial hydrophilic modification of superhydrophobic filter paper: Soak the filter paper mask prepared in step (2) in 0.5 mol / L carbonic acid solution, take it out after infiltration, and cover it with ...

Embodiment 3

[0034] (1) Preparation of superhydrophobic filter paper: according to the existing silanized paper modification technology, superhydrophobic filter paper with a contact angle of 140°~150° was prepared;

[0035]Soak the filter paper with octadecyltrichlorosilane-n-hexane solution with a volume fraction of 0.1%, ultrasonically react for 5 min, rinse with n-hexane, ethanol, and distilled water three times after taking out the tweezers, and let it dry naturally at room temperature. superhydrophobic filter paper;

[0036] (2) Fabrication of the filter paper mask: on the ordinary chromatography qualitative analysis filter paper, the channel configuration of different patterns is designed by drawing software, and the filter paper mask is obtained after manual processing;

[0037] (3) Partial hydrophilic modification of super-hydrophobic filter paper: Soak the filter paper mask prepared in step (2) in 0.8 mol / L oxalic acid solution, take it out after soaking completely, and cover it w...

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Abstract

A preparation method of an acid etching modification type microfluidic paper-based analytical device includes the steps of (1) preparing super-hydrophobic filter paper; (2), preparing a filter paper mask; (3) subjecting the super-hydrophobic filter paper to local hydrophilic modification. The acid etching modification type microfluidic paper-based analytical device prepared by the preparation method has the advantages that the microfluidic paper-based analytical device is excellent in permeation effect for water and mixed solutions with a specific ratio of water, is reusable, high in stability, resistant to acid and organic solvents, highly hydrophilic and hydrophobic, easy for large-scale industrial production, can be treated through recovery or incineration after use to lead to little environmental pollution, and is particularly applicable to the fields related to clinical analysis, food safety and control and environment monitoring.

Description

technical field [0001] The invention relates to the technical field of new materials, in particular to a method for preparing acid-etched modified microfluidic paper chips. Background technique [0002] Paper chip (Microfluidic Paper-Based Analytical Devices) is a newly developed microfluidic technology on paper in recent years. It is an ideal object to replace traditional analysis methods based on silicon, glass and polymers due to its advantages such as less and less. The Whitesides research group first proposed the concept of a microfluidic paper chip as a chemical analysis device in 2007, making the paper chip gradually recognized by researchers. Its unique aspect lies in the use of hydrophobic reagents to pattern and limit hydrophilic flow channels. , guide the sample from the entrance to the determined position and realize a series of analysis and detection. This pioneering idea has made it widely used and developed in medical clinical detection, environmental analysi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00
CPCB01L3/502707B01L2300/126
Inventor 马铭何燕陈波
Owner HUNAN NORMAL UNIVERSITY