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Formula and preparing method of metronidazole suppository

A technology of Shuangzoltai suppository and formula, which is applied in the field of vaginal suppositories, can solve the problems of difficulty in controlling the uniformity of the main drug, and achieve the effects of ensuring uniformity and combination, reasonable proportioning, and optimizing texture

Inactive Publication Date: 2017-06-13
JIANGSU YUANHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] This product is a compound preparation, and the uniformity of the three main ingredients is difficult to control

Method used

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  • Formula and preparing method of metronidazole suppository
  • Formula and preparing method of metronidazole suppository
  • Formula and preparing method of metronidazole suppository

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0021] Take 8.4g of mixed fatty acid glycerides, 51.1g of paraffin and 8.4g of lanolin and heat it on a water bath at 70°C to completely dissolve to form a matrix;

[0022] Then weigh 200g metronidazole, 160g clotrimazole and 8.4g chlorhexidine acetate as raw materials and add them to the matrix, stir and mix evenly, then carry out emulsification and homogeneous emulsification for 30 minutes;

[0023] Then pass in cooling water, stir and circulate to cool down to 50°C, set the temperature of the pouring barrel at 38°C, the temperature of the feeding valve at 38°C, the pouring temperature at 40°C according to the process requirements, and the grain weight of 1.72g / grain, inject it into the PVC plug mold, and quickly Cooling, edge rolling and heat sealing, packaging to get the finished product.

[0024] According to the compound preparation of the present invention obtained by the above-mentioned embodiment formula and preparation method, the uniformity of the three main ingredi...

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PUM

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Abstract

The invention relates to a formula and preparing method of metronidazole suppository. 1000 grains of metronidazole suppository is prepared from 200 g of metronidazole, 160 g of clotrimazole, 8.4 g of chlorhexidine acetate, 8.4 g of wool grease, 51.1 g of paraffin and 1300 g of mixed fatty glyceride. According to metronidazole suppository prepared through the formula and preparing method, the uniformity of the drug components particular the main drug can be improved, the pharmacological effects of killing fungi, germs, trichomonas infection and mixed infection can be brought into play fully, and the treatment effect is good.

Description

technical field [0001] The invention belongs to the technical field of vaginal suppositories, in particular to a formulation of Shuangzotai suppository and a preparation method thereof. Background technique [0002] Shuangzotai suppository is used for bacterial vaginosis, fungal vaginitis, trichomonal vaginitis and mixed infectious vaginitis. This product is a compound preparation, each capsule contains 200 mg of metronidazole, 160 mg of clotrimazole, and 8 mg of chlorhexidine acetate. Excipients are: paraffin, lanolin, Tween-80, mixed fatty acid glycerides. The metronidazole contained in this product is an anti-anaerobic and anti-trichomonad drug; clotrimazole is a broad-spectrum antifungal drug, which has antibacterial effects on a variety of superficial and deep fungi, and its mechanism of action is to inhibit the synthesis and influence of fungal cell membranes. Its metabolic process; chlorhexidine acetate is a quaternary ammonium cationic surfactant, which has a bacte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4174A61K31/4164A61K31/155A61K9/02A61K47/44A61P15/02A61P31/04A61P31/10A61P33/02
CPCA61K31/4174A61K9/0034A61K9/02A61K31/155A61K31/4164A61K47/44A61K2300/00
Inventor 王联民范宇何井亮贾瑞巧
Owner JIANGSU YUANHENG PHARMA