Pharmaceutical composition having functions of soothing liver and harmonizing stomach, and clearing heat and relieving pain and preparation method thereof

A technology for clearing heat and relieving pain and a composition is applied in the field of pharmaceutical compositions with functions of soothing liver and stomach, clearing heat and relieving pain and the field of preparation thereof, which can solve the problems of side effects, easy recurrence of disease, unstable curative effect, etc. Good curative effect, no toxic side effects

Inactive Publication Date: 2017-06-13
THE AFFILIATED HOSPITAL OF TRADITIONAL CHINESE MEDICAL TO SOUTHWEST MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the pathogenesis of FD has not been fully clarified. Most Western medicine believes that abnormal secretion of gastrointestinal hormones and gastrointestinal motility disturbance are important mechanisms for the pathogenesis of FD. The curative effect is unstable, the disease is prone to relapse, and there are certain side effects at the same time

Method used

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  • Pharmaceutical composition having functions of soothing liver and harmonizing stomach, and clearing heat and relieving pain and preparation method thereof
  • Pharmaceutical composition having functions of soothing liver and harmonizing stomach, and clearing heat and relieving pain and preparation method thereof
  • Pharmaceutical composition having functions of soothing liver and harmonizing stomach, and clearing heat and relieving pain and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation of embodiment 1 composition of the present invention

[0031] Prescription: Bupleurum 100g, Baishao 150g, Coptidis 90g, Evodia 60g, Curcuma 100g, Salvia miltiorrhiza 120g, Yanhusuo 120g, wine rhubarb 30g, Codonopsis 150g, astragalus 200g, woody 90g, citrus aurantium 100g, licorice 30g.

[0032] Preparation Process:

[0033] (1) Weigh each bulk drug according to the prescription;

[0034] (2) Soak Salvia Miltiorrhiza and Corydalis Corydalis in 5 times the amount of 60% ethanol for 7 days, filter, recover ethanol from the filtrate, and concentrate it into a liquid extract for future use. Add 7 times the amount of water to soak the dregs of the medicine and the other eleven flavors for 0.5 hours, and decoct twice, 1 hour each time. At the same time, collect the volatile oil and place it separately; filter the decoction, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.02-1.05 (80°C), let stand f...

Embodiment 2

[0036] The preparation of embodiment 2 compositions of the present invention

[0037] Prescription: 80 parts of Bupleurum, 120 parts of white peony, 72 parts of coptis, 48 ​​parts of evodia, 80 parts of curcuma, 96 parts of salvia miltiorrhiza, 96 parts of yanhusuo, 24 parts of rhubarb, 120 parts of codonopsis, 240 parts of astragalus, 108 parts of woody fragrance, citrus aurantium Shell 120 parts, licorice 36 parts.

[0038] Preparation process: except that the addition of dextrin is 560g, other preparation processes are the same as in Example 1.

Embodiment 3

[0039] The preparation of embodiment 3 compositions of the present invention

[0040] Prescription: 120 parts of Bupleurum, 180 parts of Paeoniae Alba, 108 parts of Coptidis, 72 parts of Evodia, 120 parts of Curcuma, 144 parts of Salvia, 144 parts of Corydalis, 36 parts of Rhubarb, 180 parts of Codonopsis, 160 parts of Astragalus, 72 parts of Woody, Hovenia Shell 80 parts, licorice 24 parts.

[0041] Preparation process: except that the addition of dextrin is 840g, other preparation processes are the same as in Example 1.

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Abstract

The invention provides a pharmaceutical composition having functions of soothing liver and harmonizing stomach, and clearing heat and relieving pain. The pharmaceutical composition is prepared from 80 to 120 parts by weight of radix bupleuri, 120 to 180 parts by weight of white peony root, 72 to 108 parts by weight of coptis root, 48 to 72 parts by weight of fructus evodiae, 80 to 120 parts by weight of rhizoma curcumae, 96 to 144 parts by weight of red sage root, 96 to 144 parts by weight of rhizoma corydalis, 24 to 36 parts by weight of rheum officinale, 120 to 180 parts by weight of root of hairy asiabell, 160 to 240 parts by weight of radix astragali, 72 to 108 parts by weight of costusroot, 80 to 120 parts by weight of fructus aurantii and 24 to 36 parts by weight of licorice root. The invention also provides a preparation method and use of the pharmaceutical composition. The pharmaceutical composition has reasonable compatibility, has effects of soothing liver and harmonizing stomach, and clearing heat and relieving pain, has a remarkable effect on functional dyspepsia, has good safety and provides a novel drug choice for clinical treatment.

Description

technical field [0001] The invention relates to a pharmaceutical composition with the functions of soothing the liver and regulating the stomach, clearing away heat and relieving pain, its preparation method and application. Background technique [0002] Functional dyspepsia (FD) refers to a group of patients who have symptoms such as upper abdominal fullness, early satiety, belching, dull pain in the upper abdomen, loss of appetite, nausea, and vomiting, and the organic diseases that cause these symptoms are excluded after examination. Group clinical syndrome, the symptoms are persistent or recurrent, and the course of the disease is generally defined as more than one month or more than twelve weeks accumulated in December. FD is the most common functional gastrointestinal disease in clinical practice, and its incidence is on the rise, accounting for 30-40% of outpatient visits to gastroenterology. [0003] At present, the pathogenesis of FD has not been fully clarified. M...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P1/14A61P1/00A61P29/00A61P1/02
CPCA61K36/233A61K36/285A61K36/344A61K36/481A61K36/484A61K36/537A61K36/65A61K36/66A61K36/708A61K36/71A61K36/718A61K36/752A61K36/754A61K36/9066A61K2236/331A61K2236/333A61K2236/51A61K2300/00
Inventor 段国勋杨思进徐州肖国辉李志陈辉赵龙喻玉
Owner THE AFFILIATED HOSPITAL OF TRADITIONAL CHINESE MEDICAL TO SOUTHWEST MEDICAL UNIV
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