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Fast high-selectivity super-sensitive nickel ion colorimetric fluorescent probe and preparation method thereof

A nickel ion, fluorophore technology, applied in fluorescence/phosphorescence, chemical instruments and methods, luminescent materials, etc., can solve the problems of complex synthesis, insufficient sensitivity, and insufficient response speed, and achieve simple synthesis, good stability, Responsive effect

Inactive Publication Date: 2017-06-13
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some problems with the currently reported colorimetric and fluorescent probes, including insufficient selectivity, insufficient sensitivity, insufficient response speed, and complex synthesis.

Method used

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  • Fast high-selectivity super-sensitive nickel ion colorimetric fluorescent probe and preparation method thereof
  • Fast high-selectivity super-sensitive nickel ion colorimetric fluorescent probe and preparation method thereof
  • Fast high-selectivity super-sensitive nickel ion colorimetric fluorescent probe and preparation method thereof

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Effect test

Embodiment 1

[0033]

[0034] (Scheme 1) Dissolve 410.5mg (1mmol) of rhodamine-like fluorophore compound in 15mL of anhydrous dichloromethane, then add 120.5mg (1mmol) of allyl chloroformate, then stir and react at 25°C for 3h, after the reaction The dichloromethane was evaporated to dryness to obtain the crude product. Finally, a mixed system of dichloromethane and petroleum ether (1:5, v / v) was used for column chromatography to obtain 306.6 mg of a pink pure product with a yield of 62%.

[0035] (Scheme 2) Dissolve 410.5mg (1mmol) of rhodamine-like fluorophore compound in 15mL of anhydrous dichloromethane, then add 180.8mg (1.5mmol) of allyl chloroformate, then stir and react at 25°C for 3h, and the reaction ends Afterwards, the dichloromethane was evaporated to dryness to obtain the crude product. Finally, a mixed system of dichloromethane and petroleum ether (1:5, v / v) was used for column chromatography to obtain 385.7 mg of a pink pure product with a yield of 78%.

[0036] (Scheme...

Embodiment 2

[0040] Fig. 1(a) is a diagram of the change in fluorescence spectrum of the nickel ion colorimetric fluorescent probe (20 μM) after adding nickel ions (0-5 μM). It can be clearly seen from the figure that with the increase of the concentration of nickel ions added, the fluorescence intensity at 645 nm of the solution gradually increases. Moreover, it can be seen from the illustration that the fluorescence intensity at 645 nm has a good linear relationship with the concentration of the added nickel ions, which proves that the fluorescent probe can be used for quantitative analysis of nickel ions.

[0041] Fig. 1(b) is a change diagram of the absorption spectrum of the nickel ion colorimetric fluorescent probe (20 μM) after adding nickel ions (0-2 μM). It can be seen from the figure that as the concentration of nickel ions increases, the absorbance value at 580 nm of the solution increases gradually. From the illustration, we can clearly see that after adding nickel ions, the c...

Embodiment 3

[0043] figure 2 It is a graph showing the change of fluorescence spectrum with time after adding nickel ions (2 μM) to the nickel ion colorimetric fluorescent probe (20 μM). It can be clearly seen from the figure that after the addition of nickel ions, the fluorescence intensity reaches the maximum after 2 minutes and remains unchanged, which indicates that the probe reacts rapidly with nickel ions and can provide a rapid analysis method for the determination of nickel ions.

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Abstract

The invention relates to a fast high-selectivity super-sensitive nickel ion colorimetric fluorescent probe and a preparation method thereof. Specifically, the probe provided by the invention is an allyl carbonic ester compound and can be used as a nickel ion colorimetric fluorescent probe for detecting nickel ions. The probe can realize at least one of the following technical effects: high selectively recognizing the nickel ion, quickly responding to the nickel ion, high sensitively analyzing the nickel ion, realizing the naked eye colorimetric analysis for the nickel ion and having stable properties, long-term storage and use and higher anti-jamming capability.

Description

technical field [0001] The invention relates to an allyl carbonate compound as a colorimetric fluorescent probe for nickel ions, which can rapidly perform ultrasensitive and selective identification of nickel ions, or it can measure the concentration of nickel ions in a sample. Background technique [0002] As one of the transition metals, nickel ion is an essential element for the human body and some crops. The content in the human body is extremely sensitive. When nickel is deficient, six dehydrogenases in the liver decrease, including glucose-6-phosphate dehydrogenase, lactate dehydrogenase, and lactate dehydrogenase. Hydrogenase, isocitrate dehydrogenase, malate dehydrogenase and glutamate dehydrogenase. These enzymes are involved in the generation of NADH, anaerobic glycolysis, the Krebs cycle and the release of nitrogen from amino acids. Moreover, when nickel is deficient, there are changes in the structure of liver cells and mitochondria, especially the irregular inn...

Claims

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Application Information

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IPC IPC(8): C07D311/78C09K11/06G01N21/64
CPCC07D311/78C09K11/06C09K2211/1007C09K2211/1088G01N21/643
Inventor 王作凯赵子扬柳彩云段庆霞朱宝存杜斌
Owner UNIV OF JINAN
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