High-viscosity attapulgite/polyacrylic acid nanometer composite gel and preparation method thereof

Abstract

The invention discloses a high-viscosity attapulgite / polyacrylic acid nanometer composite gel and a preparation method thereof. The nanometer composite gel is prepared from the following raw materials by weight: 1 to 3 parts of dimetyl terephthalate, 6 to 11 parts of attapulgite, 2 to 3 parts of dimethyl carbonate, 15 to 20 parts of a hydrochloric acid solution, 30 to 40 parts of a zinc sulfate solution, a proper amount of absolute ethyl alcohol, 1 to 2 parts of aluminum powder, 2 to 5 parts of a silane coupling agent KH-570, 2 to 5 parts of a silane coupling agent KH-550, 2 to 3 parts of chitosan, 0.4 to 1 part of cerium nitrate, 5 to 10 parts of acrylic acid, a proper amount of nitrogen and a proper amount of distilled water. According to the invention, chitosan used in the invention is rich in amino groups, so amino groups are provided and grafted onto attapulgite for participation in crosslinking so as to enhance the stability of a network structure; meanwhile, chitosan has adsorptivity, so the loading and adsorption capacity of a carrier is improved; and dimethyl terephthalate and dimethyl carbonate are cooperatively used, so the viscosity of the composite gel is improved.

Description

technical field [0001] The invention relates to an attapulgite carrier and its preparation, in particular to a high-viscosity attapulgite / polyacrylic acid nanocomposite gel and a preparation method thereof. Background technique [0002] Drug carrier release and targeting system can reduce drug degradation and loss, reduce side effects, and improve bioavailability, so more and more attention has been paid to its research. Due to its unique amphiphilic structure, polymer surfactants can self-assemble to form various forms of aggregates, such as micelles, microemulsions, gels, liquid crystals, vesicles, etc. These aggregates have the ability to entrap drug molecules and at the same time have good permeability to the membrane, which has become an important research field of drug carriers. Attapulgite is a hydrous-rich magnesium-aluminosilicate mineral with attapulgite as the main component and a special fibrous crystal structure. Due to its excellent adsorption, ion exchange, ...

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Problems solved by technology

[0003] In his master's thesis "Gel Phenomenon and Application of Attapulgite / Polymer Nanocomposites Prepared by In-Situ Polymerization", Zhu Longxiang prepared nanocomposite hydrogels using attapulgite and acrylic acid, but they are used as drug carriers. There are also problems of poor loading capacity, antibacterial properties, and slow-release properties