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Quality control method for euphorbia fischeriana steud processed with vinegar

A technology of vinegar wolf and wolf poison, applied in the field of quality control of vinegar wolf poison, can solve problems such as difficulty in ensuring clinical safety and stable curative effect, no unified quality control method, etc., and achieves good reproducibility, good quality and controllable quality. Effect

Active Publication Date: 2017-07-11
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Vinegar chamaejasme is widely used clinically, and has intestinal side effects, but there is no unified quality control method at present, and it is difficult to guarantee clinical safety and stable curative effect

Method used

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  • Quality control method for euphorbia fischeriana steud processed with vinegar
  • Quality control method for euphorbia fischeriana steud processed with vinegar
  • Quality control method for euphorbia fischeriana steud processed with vinegar

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Experimental program
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Embodiment 1

[0020] 1. The content determination method for simultaneous determination of two components is:

[0021] 1.1 Medicinal materials, instruments and reagents

[0022] Self-made vinegar chamaejasma: Weigh 100g of chamaejasma decoction pieces (LD), stir-fry continuously and evenly at 160°C for 10min (CLD1), 20min (CLD2), 30min (CLD3), 40min (CLD4) until the surface of the medicine turns brown-yellow . Three batches were concocted. The obtained sample names are CLD11, CLD21, CLD31, CLD41, CLD12, CLD22, CLD32, CLD42, CLD13, CLD23, CLD33, CLD43, respectively.

[0023] Waters 2695-2489 PDA high-performance liquid chromatography system; Milli-Q pure water instrument; BP211D electronic balance (German Sartorius company); KQ-500DE medical numerical control ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd.).

[0024] Reference substance for analysis: Prostratin with a purity greater than 98%, purchased from sigma; Pekinenin G self-made (WangKL, Yu HL, Wu H, Wang XZ, Pan YZ, Ch...

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Abstract

The invention relates to a quality control method for euphorbia fischeriana steud processed with vinegar, and belongs to the field of traditional Chinese medicine decoction piece quality control, wherein the quality of euphorbia fischeriana steud processed with vinegar is judged by measuring the contents of diterpenoid components such as Prostatin and Pekinenin G in euphorbia fischeriana steud processed with vinegar. According to the present invention, the quality control method for euphorbia fischeriana steud processed with vinegar is established, and the quality control method for simultaneous determining the contents of the two toxic and pharmacological components such as Prostratin and Pekinenin G in euphorbia fischeriana steud processed with vinegar by using high performance liquid chromatography is provided, wherein the quality standard is simple, and the drug quality can be well controlled; and the quality control method has advantages of strong specificity and good reproducibility, and truly reflect the safety, the effectiveness and the controlled quality of the drug.

Description

technical field [0001] The invention belongs to the field of quality control of decoction pieces of traditional Chinese medicine, and in particular relates to a quality control method of chamaejamae chamaejama. Background technique [0002] Euphorbia ebracteolata Hayata or Euphorbia fischeriana Steud is the dry root of Euphorbia ebracteolata Hayata or Euphorbia fischeriana Steud. "Compendium of Materia Medica" lists it as a poisonous herb. Improper clinical use can cause strong irritation to the skin, oral cavity and gastrointestinal mucosa. Clinically, it can mainly cause severe abdominal pain, diarrhea, blood in the stool and other gastrointestinal irritation. [0003] Vinegar chamaejasme is widely used clinically and has intestinal toxicity and side effects. However, there is no uniform quality control method at present, and it is difficult to guarantee clinical safety and stable curative effect. Wolfbane belongs to the Euphorbiaceae poisonous traditional Chinese medicin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88
CPCG01N30/88G01N2030/884
Inventor 刘莲黄剑宇郁红礼吴皓王奎龙王卫
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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