Application of alpha-oxoglutarate (salt) in aspects of fatigue resistance and muscle strength improvement

A technology of ketoglutarate and ketoglutaric acid, which is applied in the fields of muscular system diseases, neuromuscular system diseases, food science, etc., can solve problems such as insufficient intermediate products of tricarboxylic acid cycle metabolism, and achieve good promotion and application prospects. Relieves body fatigue and improves exercise capacity

Inactive Publication Date: 2017-07-21
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these programs can only alleviate the symptoms of fatigue to a certain extent, and have not fundamentally solved the problem of insufficient intermediate products of the tricarboxylic acid cycle metabolism

Method used

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  • Application of alpha-oxoglutarate (salt) in aspects of fatigue resistance and muscle strength improvement
  • Application of alpha-oxoglutarate (salt) in aspects of fatigue resistance and muscle strength improvement
  • Application of alpha-oxoglutarate (salt) in aspects of fatigue resistance and muscle strength improvement

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 Effects of α-ketoglutarate (salt) and its derivatives on the exercise ability and muscle strength of mice

[0028] 1. In order to study the effect of α-ketoglutarate (salt) and its derivatives on the exercise ability and muscle strength of mice, the experiment took mice as the research objects, and selected 40 C57BL / 6J mice aged 5 weeks. Divided into 4 groups as follows:

[0029] Control group: drinking sterile water;

[0030] Treatment group 1: Add 2% α-ketoglutarate derivative, dimethyl α-ketoglutarate (dAKG) to drinking water;

[0031] Treatment group 2: Add 2% α-ketoglutarate, calcium α-ketoglutarate (AKGCa) to drinking water;

[0032] Treatment group 3: 2% α-ketoglutarate (AKG) was added to the drinking water.

[0033] The above groups adjusted the drinking water pH to 7.0, fed and drinking ad libitum, 12 mice cycled light, the ambient humidity was 70%±10%, and the temperature was kept constant at 23°C±1°C. Add 2% α-ketoglutarate (salt) and its deriva...

Embodiment 2

[0046] Example 2 Effects of α-ketoglutarate (salt) and its derivatives on blood biochemical indicators in mice

[0047] 1. In order to study the effect of α-ketoglutarate (salt) and its derivatives on the blood biochemical indicators of mice, the experiment took mice as the research objects, and selected 40 5-week-old C57BL / 6J mice, with an average score of 4 groups, as follows:

[0048] Control group: drinking sterile water;

[0049] Treatment group 1: Add 2% α-ketoglutarate derivative, dimethyl α-ketoglutarate (dAKG) to drinking water;

[0050] Treatment group 2: Add 2% α-ketoglutarate, calcium α-ketoglutarate (AKGCa) to drinking water;

[0051] Treatment group 3: 2% α-ketoglutarate (AKG) was added to the drinking water.

[0052] The above groups adjusted the drinking water pH to 7.0, fed and drinking ad libitum, 12 mice cycled light, the ambient humidity was 70%±10%, and the temperature was kept constant at 23°C±1°C. 2% α-ketoglutarate (salt) and its derivatives were ad...

Embodiment 3

[0058] Example 3 Effects of α-ketoglutarate (salt) and its derivatives on the activity of mouse skeletal muscle exercise metabolic enzymes

[0059] 1. In order to study the effect of α-ketoglutarate (salt) and its derivatives on mouse skeletal muscle exercise metabolic enzymes, the experiment took mice as the research object, and selected 40 5-week-old C57BL / 6J mice, with an average Divided into 4 groups as follows:

[0060] Control group: drinking sterile water;

[0061] Treatment group 1: Add 2% α-ketoglutarate derivative, dimethyl α-ketoglutarate (dAKG) to drinking water;

[0062] Treatment group 2: Add 2% α-ketoglutarate, calcium α-ketoglutarate (AKGCa) to drinking water;

[0063] Treatment group 3: 2% α-ketoglutarate was added to the drinking water.

[0064] The above groups adjusted the drinking water pH to 7.0, fed and drinking ad libitum, 12 mice cycled light, the ambient humidity was 70%±10%, and the temperature was kept constant at 23°C±1°C. Add 2% α-ketoglutarat...

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Abstract

The invention discloses an application of alpha-oxoglutarate (salt) and an derivative thereof in serving or preparing drugs or healthcare products for alleviating body fatigue and improving muscle strength. According to discovery of researches, the alpha-oxoglutarate (salt) and the derivative thereof can remarkably improve rapid movement, slow movement and grasp power of animals, lower serum urea nitrogen and lactate levels, improve muscle metabolism enzyme activity and accelerate energy supply; the alpha-oxoglutarate is amino acid metabolites and is an endogenous component originally existing in blood after human motion, no negative effect on human bodies is caused after use, and efficacies of enhancing muscle strength and alleviating body fatigue are achieved under the premise that normal health condition is guaranteed; meanwhile, excessive alpha-oxoglutarate can be completely metabolized by the body, no adverse effect on human health is caused, the alpha-oxoglutarate can be used directly, technical and cost supports are provided for preparation of the healthcare products for alleviating the body fatigue and improving athletic ability, and good application prospect is achieved.

Description

technical field [0001] The invention belongs to the technical field of human health products and medicines. More specifically, it relates to the application of α-ketoglutarate (salt) and its derivatives in the preparation of human health products and medicines for anti-fatigue and improving exercise capacity. Background technique [0002] Fatigue refers to a kind of normal physiological phenomenon that must occur when mental or physical strength reaches a certain stage. The performance of fatigue is mainly the decrease of energy in the body and the decline of muscle strength during exercise. Measuring the time from continuous exercise to exhaustion can reflect the endurance of the body, and changes in biochemical indicators of the body caused by heavy exercise can reflect the degree of fatigue. Therefore, the so-called anti-fatigue is to delay the occurrence of fatigue and accelerate the elimination of fatigue. Improving endurance and delaying fatigue are important topics ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/194A61K31/225A61P21/00A61P21/06A23L33/10
CPCA61K31/194A61K31/225
Inventor 束刚蔡兴才袁业现朱晓彤王丽娜王松波高萍江青艳
Owner SOUTH CHINA AGRI UNIV
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