Preparation method of biomacromolecule compound stable quercetagetin

A technology of quercetin tagetin and biological macromolecules, applied in the field of delivery system, can solve the problems of low bioavailability, sensitivity, poor water solubility, etc., to improve water solubility, reduce photodegradation and thermal degradation rate, increase Effect of embedding rate and loading

Inactive Publication Date: 2017-07-28
CHINA AGRI UNIV
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  • Claims
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Problems solved by technology

[0007] Aiming at the shortcomings of quercetin tagetin in its poor water solubility, sensitivity to light, heat and oxygen, and low bioavailability, the present invention provides a preparation method of quercetin tagetin in a stable state of a biomacromolecular compound. The method is charact

Method used

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  • Preparation method of biomacromolecule compound stable quercetagetin
  • Preparation method of biomacromolecule compound stable quercetagetin

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Effect test

Embodiment 1

[0024] Such as figure 1 As shown, dissolve 0.4g zein, 0.08g propylene glycol alginate (the mass ratio of the two is 5:1) and 20mg quercetin in 40mL ethanol solution with a volume fraction of 80%, and magnetically stir to make it fully dissolve. Use a syringe to inject 40mL of the above solution into a large beaker filled with 120mL of water and keep stirring at a stirring speed of 200r / min to form a cloudy yellow solution, which is Zein-Propylene Glycol Alginate-Quercetin Wanshou Inulin Ternary Complex Dispersion. Concentrate the ternary compound dispersion by vacuum rotary evaporation, the pressure is -0.1MPa, the temperature is 40°C, the rotation speed is 300r / min, the evaporation time is 30min, the volume of the ternary compound concentrate is the volume of the ternary compound dispersion 1 / 4 of the ternary complex concentrate; the ternary complex concentrate was centrifuged to remove particle aggregates, the speed of the centrifuge was 4000r / min, and the centrifugation t...

Embodiment 2

[0027] Such as figure 1 As shown, dissolve 0.4g zein, 0.2g propylene glycol alginate (the mass ratio of the two: 2:1) and 50mg quercetin in 40mL ethanol solution with a volume fraction of 70%, and stir it with magnetic force to make it fully dissolve. Use a syringe to inject 40mL of the above solution into a large beaker filled with 200mL of water and keep stirring at a stirring speed of 500r / min to form a cloudy yellow solution, which is Zein-Propylene Glycol Alginate-Quercetin Wanshou Inulin Ternary Complex Dispersion. Concentrate the ternary compound dispersion by vacuum rotary evaporation, the pressure is -0.1MPa, the temperature is 50°C, the rotation speed is 300r / min, the evaporation time is 20min, the volume of the ternary compound concentrate is the volume of the ternary compound dispersion 1 / 4 of the ternary complex concentrate; the ternary complex concentrate is centrifuged to remove particle aggregates, the centrifuge speed is 4000r / min, and the centrifugation tim...

Embodiment 3

[0030] Such as figure 1 As shown, dissolve 0.4g zein, 0.8g propylene glycol alginate (the mass ratio of the two is 1:2), 100mg quercitin in 40mL ethanol solution with a volume fraction of 60%, and magnetically stir to make it fully dissolve. Use a syringe to inject 40mL of the above solution into a large beaker filled with 200mL of water and keep stirring at a stirring speed of 500r / min to form a cloudy yellow solution, which is Zein-Propylene Glycol Alginate-Quercetin Wanshou Inulin Ternary Complex Dispersion. Concentrate the ternary compound dispersion by vacuum rotary evaporation, the pressure is -0.1MPa, the temperature is 55°C, the rotation speed is 300r / min, the evaporation time is 15min, the volume of the ternary compound concentrate is the volume of the ternary compound dispersion 1 / 4 of the ternary complex concentrate; the ternary complex concentrate was centrifuged to remove particle aggregates, the speed of the centrifuge was 4000r / min, and the centrifugation time...

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Abstract

The invention discloses a preparation method of biomacromolecule compound stable quercetagetin, and belongs to the technical field of transmission systems in function factor steady-state technology. According to the method, zein and propylene glycol alginate serve as raw materials, the quercetagetin serves as bioactive substances, a zein-propylene glycol alginate biomacromolecule compound loaded the quercetagetin is prepared by an anti-solvent co-precipitation method, the weight ratio of the zein to the propylene glycol alginate is 40:1-1:10, and the adding amount of the quercetagetin is 0.1wt%-2.0wt%. The dried biomacromolecule compound is spongy, water solubility of the quercetagetin is remarkably improved, the embedding rate of the quercetagetin is 90% or more, the loading amount of the quercetagetin is 6%-15%, the light degradation rate and the heat degradation rate of the quercetagetin are reduced, and the bioavailability of the quercetagetin is obviously improved. The preparation method can provide new ideas and new pathways for function factor stabilization.

Description

technical field [0001] The invention belongs to the technical field of delivery system in the stabilization technology of functional factors, and in particular relates to a preparation method of stable quercetin tagetin of biomacromolecular complex. Background technique [0002] As a kind of polyhydroxy flavonoids, quercetin tagetin has various biological functions and pharmacological effects such as anti-oxidation, anti-cancer, anti-inflammation, anti-bacterial, anti-virus, etc. It can effectively prevent cardiovascular diseases and significantly improve human immunity . However, quercetin is insoluble in water, sensitive to light, heat, and oxygen, prone to degradation, and low in bioavailability, which obviously limits its application in the food field. Existing studies have shown that polysaccharides and protein biomacromolecules can be used for the embedding, protection and delivery of various bioactive substances due to their safety, biodegradability and strong stabil...

Claims

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Application Information

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IPC IPC(8): A61K47/42A61K47/36A61K31/352A61P39/06A61P29/00A61P35/00
CPCA61K47/42A61K31/352A61K47/36
Inventor 高彦祥孙翠霞代蕾
Owner CHINA AGRI UNIV
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