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Preparation method of double network hydrogel with orthogonal regulation of mechanical properties and drug release properties

A technology with mechanical properties and dual networks, applied in medical science, prosthesis, etc., can solve the problems of lack of orthogonal control of mechanical properties and drug release properties, and achieve the effects of convenient remote control, short time, and wide application range.

Active Publication Date: 2019-08-23
CHINA UNIV OF GEOSCIENCES (BEIJING)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hydrogel has self-healing ability and good biocompatibility, but it does not have orthogonal regulation of mechanical properties and drug release properties

Method used

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  • Preparation method of double network hydrogel with orthogonal regulation of mechanical properties and drug release properties
  • Preparation method of double network hydrogel with orthogonal regulation of mechanical properties and drug release properties

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1. Preparation of polyacrylic acid powder grafted with β-cyclodextrin:

[0033] 1. Add 400mg (13.3mg / mL) polyacrylic acid to 30ml pH 5.6 phosphate buffer solution, stir evenly with magnetic force;

[0034] 2. Add 2130 mg of activator 1-ethyl-(3-dimethylaminopropyl) carbodiimide to the solution in step 1 (2 times the molar amount of carboxyl groups on polyacrylic acid in step 1) and N -Hydroxysuccinimide 1278mg (2 times the molar weight of carboxyl groups on polyacrylic acid in step 1), stirred at room temperature for 2h;

[0035] 3. Add 630 mg of monoamino β-cyclodextrin (0.1 times the molar amount of carboxyl groups on polyacrylic acid in step 1) to the solution in step 2, and stir at room temperature for 24 hours;

[0036] 4. Transfer the solution in step 3 to a 8000-14000 dialysis bag, and dialyze with deionized water for 2 weeks;

[0037] 5. Freeze-dry the dialyzed solution in step 4. The freeze-drying conditions are as follows: the temperature of the cold well of...

Embodiment 2

[0045] 1. Preparation of polyacrylic acid powder grafted with β-cyclodextrin:

[0046] 1. Add 400mg (13.3mg / mL) polyacrylic acid to 30ml pH 5.4 phosphate buffer solution, stir evenly with magnetic force;

[0047] 2. Add activator 1-ethyl-(3-dimethylaminopropyl) carbodiimide 1065 mg (1 time of carboxyl molar weight on polyacrylic acid in step 1) and N to the solution in step 1 - 639 mg of hydroxysuccinimide (1 times the molar amount of carboxyl groups on the polyacrylic acid in step 1), stirred at room temperature for 1 h;

[0048] 3. Add 630 mg of monoamino β-cyclodextrin (0.1 times the molar amount of carboxyl groups on polyacrylic acid in step 1) to the solution in step 2, and stir at room temperature for 24 hours;

[0049] 4. Transfer the solution in step 3 to a 8000-14000 dialysis bag, and dialyze with deionized water for 2 weeks;

[0050] 5. Freeze-dry the dialyzed solution in step 4. The freeze-drying conditions are as follows: the temperature of the cold well of the c...

Embodiment 3

[0058] The difference between this example and Example 1 is that 500 mg (16.7 mg / mL) polyacrylic acid is added in the first step in Step 1, and the others are the same as Example 1.

[0059] The samples obtained in Example 3 were detected by the method in Example 1, and corresponding effects can also be achieved, so details are not repeated here.

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Abstract

The invention discloses a method for preparing dual-network hydrogel capable of orthogonally regulating the mechanical property and the drug release property through photo-crosslinking. The method includes the steps that firstly, polyacrylic acid and monoamino beta cyclodextrin serve as reactants to prepare polyacrylic acid powder grafted with beta cyclodextrin; secondly, the polyacrylic acid powder grafted with beta cyclodextrin is dissolved in a phosphoric acid buffer solution, and acrylamide, N'N-methylene bisacrylamide and a photoinitiator are added, and after the materials are uniformly stirred and mixed, cross-linking is conducted under ultraviolet. The method is simple in process, short in preparation period, controllable in size, high in repeatability and good in stability. The mechanical property of the prepared double-network hydrogel and the release property to polypeptides and other drugs can be orthogonally regulated and do not interfere with each other. The one-weight network controls the mechanical strength by adjusting a polymer network, and the one-weight network regulates controlled release by adjusting the affinity with drug molecules. The double-network hydrogel has a wide application prospect in the aspects of biological medicine, tissue engineering and the like.

Description

technical field [0001] The invention belongs to the technical field of preparation of tissue engineering biomaterials, in particular to a method for preparing double network hydrogels with orthogonal regulation of mechanical properties and drug release properties. Background technique [0002] Double network hydrogel is a new research direction in the past ten years. It has a designable structure, toughness, impact resistance, low friction and other excellent mechanical properties, and has a wide range of potential applications in tissue engineering, biomedicine and other fields. For covalent double-network hydrogels, the design principles are as follows: (1) hard and brittle polyelectrolyte as the first network, flexible and flexible neutral polymer as the second network; (2) the molar concentration of the second network It is 20-30 times that of the first network; (3) the first network is tightly cross-linked and the second network is loosely cross-linked to achieve an asy...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/56C08F222/38C08F2/48C08L33/26C08L87/00A61L27/20A61L27/16A61L27/52
Inventor 张以河安琪栾兴龙
Owner CHINA UNIV OF GEOSCIENCES (BEIJING)
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