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Method for preparing functional beverage for treating rheumatoid arthritis

A technology for rheumatoid arthritis and beverages, applied in the biological field, can solve the problems of large side effects and low efficacy of drugs, and achieve the effect of shortening the treatment time

Inactive Publication Date: 2017-09-08
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a drink for treating rheumatoid arthritis in order to solve the problem of large side effects and low curative effect of rheumatoid arthritis drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] ① Preparation of propolis flavonoid solution

[0029] Put the propolis in liquor with an alcohol content of 60°, extract it in a water bath at 80°C for 3 hours, extract once in total, and centrifuge at 5000r / min for 5 minutes to separate the solid and liquid, remove the solid propolis residue, and extract the propolis with liquor with an alcohol content of 60° The flavone extract is configured as a propolis flavonoid solution with a concentration of 0.326 mg / mL; the alcohol content is the volume percentage of ethanol contained in food-grade liquor.

[0030] ② Preparation of bee venom active peptide solution

[0031]The bee venom was eluted with Sephadex G-25 with distilled water, the flow rate was controlled at 28mL / h, the molecular weight of each separated component was measured, and the layers with molecular weights of 2035Da, 2587Da and 2840Da were collected under the Sephadex column The components were analyzed and freeze-dried, and the obtained solid sample was th...

Embodiment 2

[0044] ① Preparation of propolis flavonoid solution

[0045] Put the propolis in liquor with an alcohol content of 70°, extract it in a water bath at 90°C for 4 hours, extract twice in total, and centrifuge at 4000r / min for 6 minutes to separate the solid and liquid, remove the solid propolis residue, and extract the propolis with liquor with an alcohol content of 70° The flavonoid extract is configured into a propolis flavonoid solution with a concentration of 0.217 mg / mL;

[0046] Described alcohol content is the percentage by volume of ethanol contained in the food-grade liquor.

[0047] ② Preparation of bee venom active peptide solution

[0048] The bee venom is eluted with Sephadex G-25 with distilled water, the flow rate is controlled at 30mL / h, the molecular weight of each separated component is measured, and the layers with molecular weights of 2035Da, 2587Da and 2840Da are collected under the Sephadex column The components were analyzed and freeze-dried, and the obt...

Embodiment 3

[0061] ① Preparation of propolis flavonoid solution

[0062] Put the propolis in liquor with an alcohol content of 50°, extract it in a water bath at 70°C for 2 hours, extract 3 times in total, and centrifuge at 3000r / min for 4 minutes for solid-liquid separation, remove the solid propolis residue, and extract the propolis with liquor with an alcohol content of 50° The flavonoid extract is configured into a propolis solution with a concentration of 0.109 mg / mL;

[0063] Described alcohol content is the percentage by volume of ethanol contained in the food-grade liquor.

[0064] ② Preparation of bee venom active peptide solution

[0065] The bee venom was eluted with Sephadex G-25 with distilled water, the flow rate was controlled at 26mL / h, the molecular weight of each separated component was measured, and the layers with molecular weights of 2035Da, 2587Da and 2840Da were collected under the Sephadex column The components were analyzed and freeze-dried, and the obtained sol...

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PUM

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Abstract

The invention discloses a method for preparing a functional beverage for treating rheumatoid arthritis, and belongs to the technical field of biology. The functional beverage for treating rheumatoid arthritis is prepared by compounding a bee venom bioactive peptide solution and a propolis flavone solution, wherein the bee venom bioactive peptide solution is an animal polypeptide solution separated from bee venom, and the propolis flavone solution is an active substance extracted from raw propolis. A sephadex column chromatography is combined with high-speed crushing, centrifugation and an organic solvent extraction method to obtain bee venom bioactive peptide and propolis flavone. Compared with drugs namely aspirin, the beverage for treating rheumatoid arthritis has the effect of treating the rheumatoid arthritis without damaging renal functions. After the beverage provided by the invention is drunk, pains of bodies suffering from rheumatism can be relieved to a certain extent, and the beverage is small in side effects on bodies, and can be drunk for a long term.

Description

technical field [0001] The invention relates to a method for preparing a functional drink for treating rheumatoid arthritis, belonging to the field of biotechnology. Background technique [0002] Rheumatoid arthritis is a common chronic autoimmune disease. Its pathological manifestations are inflammatory synovial hyperplasia and destruction of articular cartilage and bone. Traditional Chinese medicine classifies it into the category of "arthritis". Traditional Chinese medicine has a long history of preventing and treating rheumatoid arthritis, and bee acupuncture is widely used clinically to treat arthralgia. The bee needle liquid in bee needles is bee venom. The melittin, melittin and cell hypertrophy degranulating peptide in bee venom have antibacterial, anti-inflammatory and analgesic effects. The flavonoids in propolis have anti-inflammatory and analgesic effects. , because propolis has multiple pharmacological activities, propolis products are favored by consumers in t...

Claims

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Application Information

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IPC IPC(8): A23L2/38A23L33/10A61K38/02A61P19/02A61P29/00A61K35/644
CPCA61K38/02A23L2/38A23L33/10A61K9/0095A61K35/644A23V2002/00A23V2200/30A23V2250/204A23V2250/55A61K2300/00
Inventor 王元秀孙敏梁杰
Owner UNIV OF JINAN
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