Preparation method of silk fibroin compound bioglass tissue repair material

A technology of silk fibroin and bioglass, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of poor drug adhesion and poor mechanical properties, and achieve the effect of improving mechanical properties, increasing porosity, and facilitating adhesion

Inactive Publication Date: 2017-09-15
HEFEI CHUANGWO TECH CO LTD
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  • Abstract
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Problems solved by technology

However, in view of the existence of its amorphous silicon skeleton, bioglass still presents an amorphous form, poor...

Method used

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Embodiment 1

[0020] A preparation method of silk fibroin composite biological glass tissue repair material includes the following steps:

[0021] Step 1: De-pupa the silkworm cocoons and place them in a boiling aqueous sodium carbonate solution with a mass concentration of 0.5%, with a bath ratio of 1:50. Remove the surface sericin, remove the silky cocoons and wring them dry, and repeat After the above operation once, wash with deionized water and blow dry to obtain degummed silk fibroin. Use 9M lithium bromide aqueous solution to dissolve the degummed silk fibroin. The weight ratio of silk fibroin to lithium bromide aqueous solution is 1:10, and the dissolution temperature is 40°C. The dissolution time is 2h. After the silk fibroin is completely dissolved, add 1.5 times the volume of the solution to dilute with deionized water, centrifuge for ten minutes at a speed of 3500 rpm, and then filter with vacuum filtration. The filtrate is placed in a dialysis bag , Dialysis was continued for thre...

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PUM

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Abstract

The invention relates to a preparation method of a silk fibroin compound bioglass tissue repair material and belongs to the field of biomedical materials. The preparation method comprises the following steps: preparing a silk fibroin nano solution; preparing a bioglass solution; and performing electrostatic spinning to prepare the repair material. The silk fibroin can improve the mechanical properties of the material and the bioglass can improve the medical property of the material. The tissue repair material prepared by the invention has good mechanical properties, tissue repair property and medical adhesiveness.

Description

Technical field [0001] The invention belongs to the field of biomedical materials, and particularly relates to a preparation method of a silk fibroin composite bioglass tissue repair material. Background technique [0002] Since the discovery of bioglass, people have paid more attention to the influence of bioglass components on biological activity. The rise of nanotechnology has enabled people to realize that structure also has an important impact on biological activity, and pay more attention to the impact of size effects and microscopic fine structures on the structure and performance of materials. The nano-bioglass and mesoporous bioglass developed and designed from the nanometer size have attracted the attention of domestic and foreign scholars. Bioglass can activate cell genes, help enhance cell proliferation and differentiation, and has the effects of osteoinduction and bone conduction. However, in view of the existence of its amorphous silicon framework, bioglass still ...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/56A61L27/54A61L27/58A61L27/50
CPCA61L27/46A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/112A61L2300/252A61L2300/412A61L2300/604A61L2430/02C08L89/00
Inventor 王吉鹏
Owner HEFEI CHUANGWO TECH CO LTD
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