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Mini-type wearable non-invasive blood glucose monitor

A blood glucose monitor and wearable technology, applied in the field of miniature wearable non-invasive blood glucose monitor, can solve the problem that the shape, specification or operation and use are not suitable for human body detection, measurement result accuracy, stability and repeatability Unsatisfactory performance, inability to meet live detection, dynamic real-time monitoring and rapid detection, etc., to achieve the effect of easy fixation and testing, good man-machine combination effect, and wide application range

Inactive Publication Date: 2017-09-19
浙江澍源智能技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Raman spectroscopy is very sensitive to test conditions. The acquisition lens of the existing optical probe has a fixed focal length, but in actual measurement, especially in live detection, it is often impossible to ensure that the light source is accurately focused on the measured sample, resulting in the accuracy of the measurement results , stability and repeatability are not ideal, and cannot meet the requirements of live detection, dynamic real-time monitoring, and rapid detection
[0007] In addition, the optical probes of existing blood glucose monitors are not designed and developed specifically for living body detection, especially for human body detection. They are not suitable for human body detection in terms of shape, specification, or operation, and cannot meet the needs of living body detection. Requirements for convenience and comfort

Method used

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  • Mini-type wearable non-invasive blood glucose monitor
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  • Mini-type wearable non-invasive blood glucose monitor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] A miniature wearable non-invasive blood glucose monitor, such as figure 1 As shown, it includes a fiber optic probe, a laser 1, and a spectral detector 6;

[0049] The optical fiber probe includes a laser channel, a Raman scattering collection channel and a detection channel;

[0050] An incident optical fiber (3), a first collimator lens 4, and a first optical filter 10 are sequentially arranged in the laser channel along the propagating direction of the incident laser light;

[0051] The incident optical fiber 3 transmits the incident laser light to the first collimating lens 4, and the direction of the incident laser light is controlled by the first collimating lens 4, so that the incident laser light is accurately directed to the first optical filter 10, and the first optical filter 10 Only lasers with specific wavelengths are allowed to pass through;

[0052] The detection channel is respectively connected to the laser channel and the Raman scattering channel thr...

Embodiment 2

[0065] On the basis of Example 1, this embodiment provides the method for calculating blood glucose concentration by partial least squares method, including:

[0066] The blood glucose concentration Y is obtained by formula (1):

[0067] Y=f(x)+Error (1)

[0068] In formula (1), f(x) is the dominant factor:

[0069] f(x)=k 1 x 1 +k 2 x 2 +…+k n x n +k n+1 x 1 2 +k n+2 x 2 2 +…+k 2n x n 2 +b

[0070] Among them, n is the number of characteristic peaks in the spectrum with the same position as the glucose standard spectrum, x n is the area of ​​the characteristic peak at the same position as the standard spectrum of glucose in the spectrum, k 1 ,k 2 ,...,k 2n is the first coefficient;

[0071] In this embodiment, the partial least squares method is used to obtain k 1 ,k 2 ,...,k 2n ;

[0072] Error means residual, Error=j 1 x' 1 +j 2 x' 2 +…+j m x' m +j m+1 x' 2 1 +j m+2 x' 2 2 +…+j 2m x' 2 m +c

[0073] Among them, m is the number of rem...

Embodiment 3

[0077] On the basis of Embodiment 1, this embodiment further includes a wristband 15 on which the self-focusing lens 13 is arranged.

[0078] The probe provided in Embodiment 1 can be fixed on a living body, especially a human body (such as a human wrist, arm, etc.) through a wrist strap and Velcro, not only capable of single detection, but also dynamic real-time monitoring.

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Abstract

The invention discloses a mini-type wearable non-invasive blood glucose monitor. The mini-type wearable non-invasive blood glucose monitor comprises an optical fiber probe, a laser device and a spectrometer detector, wherein the optical fiber probe comprises a laser channel, a Raman scattering collection channel and a detection channel; the laser channel is connected with the detection channel through an optical filter; the laser channel is internally provided with an incidence optical fiber, a first collimation lens and an optical filter; the detection channel is internally provided with a second collimation lens, a detection optical fiber and a self-focusing lens; the Raman scattering collection channel is internally provided with an optical filter, a third collimation lens and a collection optical fiber; the laser device is connected with the incidence optical fiber in the laser channel; and the spectrometer detector is connected with the second optical filter in the Raman scattering collection channel. According to the mini-type wearable non-invasive blood glucose monitor disclosed by the invention, the self-focusing lens is used as a collection lens so that a light source can be gathered to the surface of an object to be detected; and no gap is formed between the probe and the object to be detected and a condition that a signal in the environment enters the probe is avoided.

Description

technical field [0001] The invention relates to the fields of optical detection and material analysis, in particular to a miniature wearable non-invasive blood sugar monitor. Background technique [0002] In recent years, optical detection technology, especially wearable non-invasive detection equipment suitable for the human body, has become more and more popular. Optical detection technologies such as Raman spectroscopy, infrared spectroscopy, and fluorescence spectroscopy have been applied to the detection of human physiological indicators. [0003] Raman spectroscopy (Raman) can reveal the vibrational modes of molecules and crystals of organic and inorganic substances, and Raman spectrometers can identify material components through the frequency shift information of Raman spectroscopy. Applying it to the human body can realize various physiological indicators such as blood sugar and blood lipids, and even the rapid detection and dynamic real-time detection of cancer ce...

Claims

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Application Information

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IPC IPC(8): A61B5/1455
CPCA61B5/1455A61B5/14532A61B5/14556A61B5/681
Inventor 彭波郑毅高飞朱香平聂荣志
Owner 浙江澍源智能技术有限公司
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