Compound with calcium gluconate grafted aliphatic polyester, method for preparing compound and application thereof

An aliphatic polyester and calcium gluconate technology, which is applied in the fields of polymer chemistry and biomedical materials, can solve problems that need to be improved, and achieve the effects of suitable degradation performance, strong operability, and good repair ability

Active Publication Date: 2017-09-26
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the complex has improved the interaction and degradation performance of the aliphatic polyester and cells through the functions of the corresponding components, it still needs to be improved

Method used

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  • Compound with calcium gluconate grafted aliphatic polyester, method for preparing compound and application thereof
  • Compound with calcium gluconate grafted aliphatic polyester, method for preparing compound and application thereof
  • Compound with calcium gluconate grafted aliphatic polyester, method for preparing compound and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Calcium gluconate anhydrous was processed to 80 μm by a ball mill, dried in vacuum at 70°C for 48 hours, and stored under the protection of argon for future use.

[0059] Under anhydrous and oxygen-free reaction conditions, calcium gluconate, lactide monomer, stannous octoate Sn(Oct) 2 and toluene (refined) were added to the reaction tube, the reaction tube was closed, and the reaction was carried out at 100° C. for 48 hours. After the reaction is complete, the product is dissolved in a solvent such as dichloromethane, isopropanol is settled, and then dried in a vacuum oven at 45° C. for 72 hours. The compound of calcium gluconate grafted aliphatic polyester of the present invention is obtained. Wherein the ratio of stannous octoate and lactide monomer is 2:100 (molar ratio), the weight ratio of calcium gluconate and lactide monomer is 0.5:100, and the volume of described toluene is lactide monomer and 2 times the sum of the weight of calcium gluconate.

Embodiment 2

[0061] Anhydrous calcium gluconate was processed by a ball mill to 100nm, dried in vacuum at 70°C for 48h, and stored under the protection of argon for future use.

[0062] Under anhydrous and oxygen-free reaction conditions, calcium gluconate, lactide monomer, stannous octoate Sn(Oct) 2 and toluene (refined) were added to the reaction tube, the reaction tube was closed, and the reaction was carried out at 100° C. for 48 hours. After the reaction is complete, the product is dissolved in a solvent such as dichloromethane, isopropanol is settled, and then dried in a vacuum oven at 45° C. for 72 hours. The compound of calcium gluconate grafted aliphatic polyester of the present invention is obtained. Wherein the ratio of stannous octoate and lactide monomer is 2:100 (molar ratio), the weight ratio of calcium gluconate and lactide monomer is 2:100, and the volume of described toluene is lactide monomer and 2 times the sum of the weight of calcium gluconate.

Embodiment 3

[0064] Anhydrous calcium gluconate was processed by a ball mill to 100 μm, dried in vacuum at 70°C for 48 hours, and stored under the protection of argon for future use.

[0065] Under anhydrous and oxygen-free reaction conditions, calcium gluconate, lactide monomer, stannous octoate Sn(Oct) 2 and toluene (refined) were added to the reaction tube, the reaction tube was closed, and the reaction was carried out at 100° C. for 48 hours. After the reaction is complete, the product is dissolved in a solvent such as dichloromethane, isopropanol is settled, and then dried in a vacuum oven at 45° C. for 72 hours. The compound of calcium gluconate grafted aliphatic polyester of the present invention is obtained. Wherein the ratio of stannous octoate and lactide monomer is 2:100 (molar ratio), the weight ratio of calcium gluconate and lactide monomer is 10:100, and the volume of described toluene is lactide monomer and 2 times the sum of the weight of calcium gluconate.

[0066] fig...

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Abstract

The invention discloses a compound with calcium gluconate grafted aliphatic polyester, a method for preparing the compound and application thereof. The method includes carrying out heterogeneous graft copolymerization reaction on calcium gluconate and aliphatic polyester monomers under the effects of catalysts to obtain the compound with the calcium gluconate grafted aliphatic polyester. The calcium gluconate is used as a main graft chain, and the aliphatic polyester monomers are used as graft monomers. The compound, the method and the application have the diversified advantages that the method includes simple and controllable preparation processes and is high in operability, and the compound can be widely produced on a large scale; the compound is excellent in cell compatibility and apatite enrichment promoting ability in cell culture experiments and biological simulation mineralization experiments, and the like.

Description

technical field [0001] The invention relates to a grafted biomedical composite material, in particular to a calcium gluconate grafted aliphatic polyester composite, a preparation method and application thereof, belonging to the fields of polymer chemistry and biomedical materials. Background technique [0002] Calcium gluconate is an important derivative of gluconic acid, which has excellent solubility, easy absorption and physiological compatibility, and is widely used in clinical medicine and food fields. Calcium gluconate is commonly used as calcium supplement and anti-inflammatory preparation. It has been reported in the literature that calcium gluconate can be used as a reinforcing agent for polyvinylpyrrolidone and methyl methacrylate copolymers. The results showed that the composite material has good biocompatibility and can enable bone reconstruction. At present, calcium gluconate is commonly used as a cross-linking agent for alginate and a chelating agent for prot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/68C08G63/08C08G63/06C08J3/16A61K9/16A61K47/34A61L27/18A61L27/50A61L27/58
CPCA61K9/1647A61K47/34A61L27/18A61L27/50A61L27/58C08G63/06C08G63/08C08G63/681C08G2230/00C08J3/16C08J2367/04
Inventor 甘志华宋乐园
Owner BEIJING UNIV OF CHEM TECH
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