Micro-molecular chip, its preparation method and application
A technology for small molecules and small molecular compounds, which is applied in the analysis of materials, material analysis by optical means, material inspection products, etc. question
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Embodiment 1
[0164] Example 1 Screening of Small Molecular Compounds
[0165] The chip used in this example is a two-dimensional photocrosslinking chip, which includes a solid support, polyethylene glycol modified at both ends and a photocrosslinking agent; the polyethylene glycol modified at both ends is modified by a riveting group at one end, The other end is polyethylene glycol modified by a binding group, the solid support is connected to the riveting group, and the photocrosslinking agent is connected to the binding group; the riveting group is -SH, and the binding group is -COOH 3 , its preparation method is:
[0166] Step 1: Take polyethylene glycol and connect it with the riveting group and the binding group respectively to obtain polyethylene glycol modified at both ends;
[0167] Step 2: Take the solid support and connect it with the riveting group after pretreatment;
[0168] Step 3: After activating the binding group, it is coupled with the photocrosslinking agent through ac...
Embodiment 2
[0228] Example 2 Preparation of Small Molecule Chip
[0229] The chip used in this example is a two-dimensional photocrosslinking chip, which includes a solid support, polyethylene glycol modified at both ends and a photocrosslinking agent; the polyethylene glycol modified at both ends is modified by a riveting group at one end, The other end is polyethylene glycol modified by a binding group, the solid support is connected to the binding group, and the photocrosslinking agent is connected to the binding group; the binding group is -S-S-, and the binding group is -OH.
[0230] Take the following small molecule compounds:
[0231] (8R,9S,13S,14S,17R)-13-Methyl-17-ethyl-17-hydroxy-1,2,4,6,7,8,9,11,12,14,15,16- Dodecylcyclopentanol[1]phenylalanine-3-one;
[0232] (2S,5R,6R)-6-[[3-(2-Chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-formyl]amino]-3,3- Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt;
[0233] 3-(3-Ethylhexahydro-1-methyl-1H-azepine-3-...
Embodiment 3
[0246] Example 3 Preparation of Small Molecule Chip
[0247] The chip used in this embodiment is a three-dimensional photocrosslinking chip, which includes a solid support, an initiation composition, an initiation monomer and a photocrosslinking agent; the initiation monomer is connected to the solid support through the initiation composition, and the photocrosslinking agent and the initiation The monomer is connected; the initiating composition includes an initiator and a diluent; the initiator is a dithiol initiator. The preparation method of the chip comprises the following steps:
[0248] Step 1: mixing the initiator and the diluent to obtain the initiator composition;
[0249] Step 2: After taking the solid support and pretreating it, the polymerization of the monomer is initiated by the initiation composition to obtain a high molecular weight polymer;
[0250] Step 3: activate the high molecular polymer, and couple with the photocrosslinking agent through acid amine co...
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