Compound aescin A liposome hydrogel patch

A technology of compound aescin and hydrogel patch, which is applied in liposome delivery, pharmaceutical formula, active ingredient of salicylic acid, etc. It can solve unsatisfactory anti-swelling effect, poor transdermal absorption effect, and skin irritation Large and other problems, to achieve good transdermal absorption effect, high total transmittance, and small skin irritation

Active Publication Date: 2017-10-17
WUHAN AIMIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is mainly to provide an anti-swelling pharmaceutical composition, and to provide an anti-swelling pharmaceutical composition for the defects of poor transdermal absorption effect,

Method used

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  • Compound aescin A liposome hydrogel patch
  • Compound aescin A liposome hydrogel patch
  • Compound aescin A liposome hydrogel patch

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0028] Example 1

[0029]

[0030] Preparation method: 1) Take 25g of soybean lecithin, 5g of cholesterol, and 0.5g of ascorbic acid in a container, add 200g of 30% ethanol solution to dissolve, then add 0.8g of aescin A, 2.5g of diethylamine salicylate, mix well, place Place in a constant temperature water bath at 45°C, and remove the solvent by rotary evaporation until a thin film is formed, then add PBS buffer solution with a pH of 6, stir and shake until a suspension is formed, filter, and collect the filtrate to obtain 65 g of liposome solution;

[0031] 2) Get 5g of Carbomer, add 60g of 30% ethanol solution and stir to fully swell, then add 2g of glycerin, 3.5g of azone and 65g of the liposome solution obtained in step 1), adjust the pH value to 6 with hydrochloric acid, continue to stir and mix Evenly and ultrasonically degassed to no bubbles, 135g of compound aescin liposome hydrogel was obtained, coated, dried until the surface was solidified, covered with a backin...

Example Embodiment

[0032] Example 2

[0033]

[0034]

[0035] Preparation method: 1) Take 15g of lecithin, 8g of cholesterol, and 0.2g of ascorbic acid in a container, add 150g of 40% ethanol solution to dissolve, add 1.2g of aescin A sodium salt, 2g of diethylamine salicylate, mix well, and place Place in a constant temperature water bath at 40°C, and remove the solvent by rotary evaporation to form a thin film, then add PBS buffer solution with a pH of 5.5, stir and shake until a suspension is formed, filter, and collect the filtrate to obtain 55 g of liposome solution;

[0036] 2) Get 3 g of hydroxypropyl methylcellulose, add 70 g of 40% ethanol solution and stir to swell fully, then add 1.5 g of glycerin, 0.5 g of propylene glycol, 1.5 g of borneol, 1 g of peppermint and 55 g of the liposome solution obtained in step 1), Use hydrochloric acid to adjust the pH value to 5, continue to stir and mix, and ultrasonically degas until there are no bubbles to obtain 132g of compound aescin lip...

Example Embodiment

[0037] Example 3

[0038]

[0039] Preparation method: 1) Take 20 g of lecithin, 3 g of cholesterol, and 0.8 g of ascorbic acid in a container, add 150 g of 25% ethanol solution to dissolve, then add 0.5 g of escin A lysine salt, 4 g of diethylamine salicylate, and mix Evenly, place in a constant temperature water bath at a temperature of 50°C, and remove the solvent by rotary evaporation until a thin film is formed, then add PBS buffer solution with a pH of 7, stir and shake until a suspension is formed, filter, and collect the filtrate to obtain a liposome solution 70g;

[0040] 2) Take 4g of sodium alginate and 2g of gelatin, add 60g of 25% ethanol solution and stir to swell fully, then add 1g of glycerin, 2g of azone and 70g of the liposome solution obtained in step 1), adjust the pH value to 5.5 with hydrochloric acid, continue Stir and mix well and ultrasonically degas until there are no bubbles to obtain 139g of compound aescin liposome hydrogel, coat it, dry it unt...

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Abstract

The invention discloses an anti-swelling pharmaceutical composition. The composition is composed of aescin A or its salt, diethylamine salicylate according to the proportion of 0.3-1.5:2-5. The invention also discloses a compound aescin A liposome hydrogel patch containing the composition and a preparation method thereof. Compared with the prior art, the anti-swelling pharmaceutical composition has better transdermal absorption effect, anti-swelling effect and security.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to an anti-swelling pharmaceutical composition, and also relates to a compound aescin A liposome hydrogel patch containing the composition and a preparation method thereof. Background technique [0002] Aescin, also known as aescinic acid, is a general term for total saponins, β-aescin or isoaescin, etc. extracted from the seeds of Aesculus in the family Aescinaceae, belonging to triterpenoid saponins. The water solubility of aescin is poor, in order to increase its solubility, it is often made into sodium salt. Studies have shown that the components with higher content in aescin are aescin A, B, C, and D. Aescin can reduce pathological increased capillary permeability, increase venous tension, reduce inflammatory substance exudation, have anti-inflammation, detumescence, pain relief, improve blood circulation, and promote the recovery of acute closed soft tissue injury. [0003] Oral bioavai...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K31/60A61K9/70A61K9/127A61K47/32A61K47/22A61K47/38A61P7/10
CPCA61K9/127A61K9/7023A61K31/60A61K31/704A61K47/22A61K47/32A61K47/38A61K2300/00
Inventor 石召华刘飞鸽关小羽李群张群铄叶利春江强
Owner WUHAN AIMIN PHARMA
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