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Application of Longhuren Dan in the preparation of drugs for preventing and/or treating diabetes

A kind of diabetes drug, the technology of the dragon and tiger, applied in the direction of drug combination, pharmaceutical formula, metabolic diseases, etc., to achieve the effect of improving insulin resistance, improving quality of life, reducing blood sugar and the risk of complications

Active Publication Date: 2021-01-26
SHANGHAI ZHONGHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the drugs for the treatment of diabetes mainly include insulin secretion promoters (sulfonylureas, repaglinide), insulin sensitizers (biguanides, thiazolidinediones) and glucosidase inhibitors (acarbose). , but they often have side effects of varying degrees, such as hypoglycemia, weight gain, cardiovascular and rhabdomyolysis, etc.

Method used

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  • Application of Longhuren Dan in the preparation of drugs for preventing and/or treating diabetes
  • Application of Longhuren Dan in the preparation of drugs for preventing and/or treating diabetes
  • Application of Longhuren Dan in the preparation of drugs for preventing and/or treating diabetes

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Experimental animals: SPF grade ICR mice and spontaneous diabetic db / db mice, 8 weeks old, male, provided by Guangdong Medical Experimental Animal Center.

[0020] Experimental drugs and reagents are shown in Table 1:

[0021] Table 1 Test Drugs and Reagents

[0022]

[0023]

[0024] The experimental equipment is shown in Table 2:

[0025] Table 2 Experimental equipment

[0026]

[0027] Experimental program

[0028] (1) Effect of Longhurendan on glucose tolerance and insulin tolerance in normal Kunming mice

[0029] Select quarantine-qualified male Kunming mice, weighing 18-22g, fasting (without water) for 12 hours, and randomly divide them into 3 groups according to blood glucose levels (the difference between groups is not more than 1.1mmol / L), which are respectively normal group and metformin positive control group, Longhurendan (100mg / kg), 8 rats in each group. The dose of metformin group was 0.2 mg / kg, and the normal group was given an equal volume ...

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Abstract

The invention relates to application of Dragon tiger panacea to preparation of medicine for preventing and / or treating diabetes, and belongs to the technical field of diabetes medicine preparation. The invention provides application of Dragon tiger panacea to preparation of medicine for preventing and / or treating diabetes. The application provided by the invention has the advantages that the protection effect of the Dragon tiger panacea on the islet cells can be realized; the improvement of molecular mechanism of the Dragon tiger panacea on insulin resistance can be realized.

Description

technical field [0001] The invention relates to the technical field of preparation of diabetes medicines, in particular to the application of Longhuren Dan in the preparation of medicines for preventing and / or treating diabetes. Background technique [0002] Diabetes is the third chronic non-communicable disease that seriously threatens human health after tumors and cardiovascular diseases. Diabetes is a chronic metabolic disease. Hyperglycemia occurs when the pancreas cannot produce enough insulin or when the body cannot effectively use insulin. Persistent high blood sugar eventually leads to damage to multiple organs, especially the blood vessels and nervous system. . [0003] At present, the number of diabetic patients is rising sharply, and diabetes and its complications have brought a heavy burden to human health and social development. According to the statistics of the International Diabetes Federation (IDF), there were 151 million people with diabetes worldwide in ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61P3/10A61K31/045
CPCA61K31/045A61K36/285A61K36/48A61K36/484A61K36/54A61K36/57A61K36/61A61K36/67A61K36/899A61K36/9064A61K36/9068A61K2300/00
Inventor 金家骅汪弼晔丁礼琴曹无介朱丽兰天李柠
Owner SHANGHAI ZHONGHUA PHARMA