Application of narrow-range chitosan oligosaccharide in preparation of functional food for preventing hyperglycemia induced by long-term high-fat diet

A functional food, narrow distribution technology, applied in the functions of food ingredients, medical preparations containing active ingredients, applications, etc., to achieve the effects of promoting glucose transport, improving excessive gluconeogenesis, and preventing hyperglycemia

Active Publication Date: 2018-06-19
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chitosan oligosaccharides are obtained by chemical or enzymatic hydrolysis of chitosan. Studies have found that chitosan oligosaccharides have various activities such as anti-tumor, lowering cholesterol, and lowering blood pressure. They are used as antioxidants and antibacterial agents in food. Chitosan oligosaccharides There is a close relationship between the molecular weight of chitosan and the effect of application technology, but the application and mechanism of action of narrow-distribution chitosan oligosaccharides in functional foods that prevent long-term high-fat diet-induced hyperglycemia have not been reported, which affects its further application.

Method used

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  • Application of narrow-range chitosan oligosaccharide in preparation of functional food for preventing hyperglycemia induced by long-term high-fat diet
  • Application of narrow-range chitosan oligosaccharide in preparation of functional food for preventing hyperglycemia induced by long-term high-fat diet
  • Application of narrow-range chitosan oligosaccharide in preparation of functional food for preventing hyperglycemia induced by long-term high-fat diet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Example 1: Effects of narrowly distributed chitosan oligosaccharides on oral glucose tolerance and insulin tolerance in long-term high-fat diet mice

[0053] The oral glucose tolerance (OGTT) test was performed on the 7th and 15th week of mouse feeding, and the insulin tolerance (ITT) test was performed on the 8th and 16th week. figure 1 It can be known that the addition of the narrow-distribution chitosan oligosaccharide of the present invention can significantly improve the oral glucose tolerance and insulin tolerance of mice with hyperglycemia induced by a high-fat diet (P<0.05). And it is better than the chitosan oligosaccharide with a commercially available average molecular weight of 3000.

Embodiment 2

[0054] Example 2: Effects of narrowly distributed chitosan oligosaccharides on fasting blood glucose and insulin levels in long-term high-fat diet mice

[0055] Table 2 Effects of narrowly distributed chitosan oligosaccharides on fasting blood glucose and insulin levels in long-term high-fat diet mice

[0056]

[0057] As shown in Table 2, the high-fat diet for 16 weeks significantly increased the fasting blood glucose, and the fasting blood glucose value of the mice in the narrow distribution chitosan oligosaccharide group significantly decreased. The insulin content of the mice in the high fat group was slightly lower than that in the normal group, but there was no significant difference. Insulin content in the narrowly distributed chitosan oligosaccharide group was significantly higher than in the fat group, indicating that this is an important compensatory response for the body to maintain blood sugar at normal levels after high-fat diet feeding. Insulin resistance ind...

Embodiment 3

[0058] Example 3: Effects of narrowly distributed chitosan oligosaccharides on liver fat infiltration in mice with long-term high-fat diet

[0059] refer to figure 2 It can be seen that, compared with the normal group, the liver of high-fat diet mice showed significant fat infiltration, the cytoplasm was occupied by a large number of fat vacuoles, and the cell boundaries became blurred, indicating that high-fat diet disrupted the normal metabolism of liver lipids in mice , a large accumulation of fat in the liver. The shape of liver cells in the mice in the narrow distribution chitosan oligosaccharide group was significantly restored, the fat vacuoles in the liver cells became smaller and smaller, the accumulation of lipids was reduced, and the fatty degeneration of the liver tissue was significantly reduced in the fat group. Compared with the high-fat diet mice, the commercially available chitosan oligosaccharide group with an average molecular weight of 3000 has reduced fa...

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Abstract

The present invention discloses an application of narrow-range chitosan oligosaccharide in a preparation of functional food for preventing hyperglycemia induced by a long-term high-fat diet. Functionsof the narrow-range chitosan oligosaccharide for preventing the hyperglycemia manifest as a reduction of fasting blood glucose. At the same time, the narrow-range chitosan oligosaccharide also improves oral glucose resistance and insulin resistance induced by the high-fat diet, increases insulin secretion and insulin sensitivity, reduces insulin resistance indexes, alleviates liver tissue fatty degeneration, and restores pancreatic tissue structures. Due to the fact that the used chitosan oligosaccharide is relatively concentrated in molecular weight distribution, a mechanism of a hypoglycemic effect is clearer. By improving excessive gluconeogenesis caused by the high-fat diet, the narrow-range chitosan oligosaccharide promotes glucose transport in muscle tissues and thereby exerts hypoglycemic effects. The used narrow-range chitosan oligosaccharide is developed into the functional food for assisting sugar-lowering and at the same time also provides strong research foundation for theapplication of the chitosan oligosaccharide in assisting the sugar-lowering.

Description

technical field [0001] The invention relates to the technical field of functional food research, in particular to the application of narrow-distribution chitosan oligosaccharide in the preparation of functional food for preventing hyperglycemia induced by long-term high-fat diet. Background technique [0002] Obesity induced by a high-fat diet is the main cause of many chronic diseases, which can easily lead to dyslipidemia, hepatic steatosis and type II diabetes. A large number of studies have shown that obesity is an important factor for insulin resistance, and insulin resistance is the basis of type II diabetes. Body fat accumulation causes insulin resistance, induces hyperinsulinemia, and reduces the utilization of glucose by muscles and other tissues. Impaired glucose tolerance occurs. In addition to inducing obesity, high-fat diet is often accompanied by hyperlipidemia and hyperglycemia. [0003] Chitosan oligosaccharides are obtained by chemical or enzymatic hydrolys...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/125A61K31/702A61P3/10
CPCA23V2002/00A61K31/702A23L33/125A23V2200/328
Inventor 夏文水王斌姜启兴许艳顺于沛沛
Owner JIANGNAN UNIV
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