A filter material for white blood cells and platelets and its preparation method
A technology for filtering materials and platelets, applied in chemical instruments and methods, filtration and separation, membrane filters, etc., can solve the problems of low platelet retention rate, increased content of anaphylatoxin C3a, inability to efficiently adsorb fibrinogen, etc. The effect of high safety and high retention effect
Active Publication Date: 2018-02-06
广州达济医学科技有限公司
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Problems solved by technology
But it has the following disadvantages: First, in practical applications, although the composite base material prepared by compounding nano-microcrystalline cellulose and polyurethane in a certain proportion has improved the specific surface area and hydrophilicity of the filter membrane, and increased the blood However, due to the large number of hydroxyl groups contained in nano-microcrystalline cellulose itself, it is extremely easy to cause complement activation in blood, resulting in a significant increase in the content of anaphylatoxin C3a in filtered blood products; the second is nano-hydroxyphosphorus Limestone is combined with the substrate in the form of coating, and there is a phenomenon of dissolution during the filtration process, which cannot efficiently adsorb fibrinogen, resulting in a low retention rate of platelets
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preparation example Construction
[0036] A) Preparation of composite base material: it consists of steps S1 to S3:
[0037] S1. Preparation of polyurethane: Take castor oil and add it to a three-neck bottle equipped with an electric stirrer and nitrogen protection, add toluene-2,4 diisocyanate dropwise, and gradually heat up to 60°C, react for 0.5h; then press NCO / OH=4:3, dropwise add the measured chain extender 1,4-butanediol, and disperse with acetone, react for 0.5h to get it;
[0038] S2. Polyurethane heat treatment: heat-treat the polyurethane prepared above, the treatment temperature is 120°C, and the treatment time is 20 minutes;
[0039] S3. Add nano-hydroxyapatite powder to the above-mentioned heat-treated polyurethane, react for 5 hours to obtain nano-hydroxyapatite / polyurethane liquid, use the casting method, drop it on a glass plate, cast it into a film, and vacuum at 40°C Dry for 12 hours; take it out, soak it in absolute ethanol for 1.5 hours, cut it into a film that meets the specifications, a...
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Abstract
The invention specifically relates to a filtering material for leucocytes and platelets, and a preparation method thereof, belonging to the field of cell filters. The filtering material is composed of a composite substrate and pyrolytic carbon coating the surface of the composite substrate, wherein the composite substrate is prepared from polyurethane and nano-hydroxyapatite in a weight ratio of 1: (0.1-0.8). The filtering material provided by the invention has high-efficiency retaining effect on both leucocytes and platelets in the whole blood; and the retention rate of leucocytes reaches 99.9999% and the retention rate of platelets is 95% or more, so the retaining effect is substantially better compared with conventional domestic filtering materials in China.
Description
technical field [0001] The invention belongs to the field of leukocyte filters, and in particular relates to a filter material for leukocytes and platelets and a preparation method thereof. Background technique [0002] Blood products without leukocyte removal are likely to cause mild side effects such as headache, nausea, chills, non-hemolytic fever reactions, and serious side effects such as viral infections. Therefore, a "leukocyte-free blood transfusion" has been widely used in recent years. Currently, methods for removing leukocytes from blood products are broadly classified into two types, centrifugation using a centrifuge to separate and remove leukocytes using the difference in specific gravity between blood components, and filtration using fibrous or porous materials to remove leukocytes. The latter is widely used because of its high ability to filter white blood cells, easy operation, and low cost. However, in recent years, as awareness of the importance of leukoc...
Claims
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IPC IPC(8): B01D39/14B01D39/16B01D39/20C08G18/32C08G18/36
CPCB01D39/14B01D39/16B01D39/2055B01D2239/0407B01D2239/0471B01D2239/10C08G18/3206C08G18/36
Inventor 王衡东
Owner 广州达济医学科技有限公司