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Blood sugar monitoring device based on biocompatibility electrode

A biocompatibility, blood glucose monitoring technology, applied in blood characterization devices, catheters, etc., can solve the problems that glucose sensors cannot be clinically applied, unreasonable design, sensor failure, etc., and achieve unique anti-biological pollution performance, noise elimination, good The effect of permeability

Inactive Publication Date: 2017-10-27
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most implantable sensors can only work stably in the body for a few days before failing, mainly due to unreasonable design, or the failure of the sensor due to complex factors such as immune response and tissue response in harsh physiological environments.
Therefore, so far, the existing glucose sensor can not be applied to clinical

Method used

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  • Blood sugar monitoring device based on biocompatibility electrode

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The glucose solution with a known concentration is detected by the zwitterionic polymer-coated continuous monitoring blood glucose monitor, and the measured concentration of the glucose solution is basically the same as the actual concentration of the solution, which proves the accuracy of the device in vitro measurement.

Embodiment 2

[0034] The continuous monitoring blood glucose monitor coated with zwitterionic polymer and the continuous blood glucose monitor without coating were inserted under the skin of the experimental mice at the same time to measure the blood glucose concentration in the mice, and the blood glucose concentration of the mice was regularly drawn to measure the blood glucose concentration. Device measurements were made in mice subcutaneously for comparison. The equipment was not calibrated during the experiment. The experimental results show that the measured value of the continuous monitoring blood glucose monitor after zwitterionic polymer coating is basically the same as the blood glucose concentration obtained by direct measurement of blood, while the blood glucose concentration obtained by the continuous blood glucose monitor without coating is consistent with the blood glucose value obtained by direct measurement There is a certain difference, demonstrating that the continuous mo...

Embodiment 3

[0036] The zwitterionic polymer-coated continuous monitoring blood glucose monitor and the non-coated continuous blood glucose monitor were inserted under the skin of the experimental mice at the same time to measure the blood glucose concentration in the mice. The uncoated sensor started on the first day after implantation Shows significant noise, so blood glucose calibration is required to correct for signal trends. In contrast, zwitterionic polymer-coated sensors showed significant improvements in eliminating sensing noise and enabled accurate recording of glucose levels without recalibration, which is in contrast to uncoated continuous glucose monitors. In stark contrast, it needs to be recalibrated at least 4 times on the first day of use and at least 2 times a day thereafter. This further demonstrates that the Zwitterionic polymer-coated continuous monitoring glucose monitor can accurately measure blood glucose levels in mice without calibration.

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Abstract

The invention belongs to the technical field of blood sugar monitoring products, and particularly discloses a blood sugar monitoring device based on a biocompatibility electrode. The blood sugar monitoring device comprises a continuous monitoring blood sugar monitor body and a probing electrode connected to the continuous monitoring blood sugar monitor, and the surface of the probing electrode is coated with a biocompatibility electrode coating. The blood sugar monitoring device based on the biocompatibility electrode can effectively inhabit the generation of inflammation, improve the blood sugar monitoring precision, and avoid the pain and inconvenience brought to a user due to frequent calibration at the same time.

Description

technical field [0001] The invention belongs to the technical field of blood sugar monitoring devices, and in particular relates to a blood sugar monitoring device based on biocompatible electrodes Background technique [0002] In recent years, the incidence of diabetes has been increasing year by year, which has caused great troubles to people's lives. It has become the third chronic disease that seriously threatens human health after tumors and cardiovascular diseases. my country has become the "hardest-hit area" of diabetes and is the second largest country in the world with diabetes. What is even more worrying is that more and more children have become diabetics. Early diagnosis and treatment of diabetic patients, effective control of blood sugar concentration and good living habits can effectively reduce the risk of complications. Therefore, the research and development of simple, fast and accurate glucose detection methods has become a hot spot that people pay attenti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/145A61B5/1473
Inventor 谢曦陈惠琄杭天柳成林吴江明杨伯儒王自鑫肖帅林迪安杨成端辜美霖潘烁琳
Owner SUN YAT SEN UNIV
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