Modular fixture for microfluidic chip

Abstract

A modular fixture for a microfluidic chip comprises upper plate assemblies and lower plate assemblies and further comprises movable clamps, wherein a space for accommodating the microfluidic chip is formed between the upper plate assemblies and the lower plate assemblies; each upper plate assembly comprises a fixture cover plate and a liquid feed module which is detachably connected to the fixture cover plate, and a liquid feed pipe communicated with the space is arranged on the liquid feed module; each lower plate assembly is provided with support rods, through holes allowing the support rods to penetrate out are formed in the corresponding upper plate assembly, the support rods penetrate the corresponding upper plate assembly through the through holes, and the movable clamps are fixed on the support rods at the upper part of the upper plate assembly and propped against or loosened from the upper plate assembly by rotating in different directions, so that the upper plate assembly and the lower plate assembly are in a locking state or unlocking state. The modular fixture for the microfluidic chip is simple in structure and easy to assemble and dismount.

Description

technical field [0001] The invention relates to the field of biomedical detection, and further relates to a modular microfluidic chip fixture. Background technique [0002] In recent years, point-of-care testing (POCT) systems have begun to be applied in the field of biomedicine. It mainly reduces the cost of testing by streamlining testing devices and operating procedures, and realizes on-site testing by non-professionals, which is of great significance for improving medical construction in remote areas and promoting personalized medicine. The microfluidic chip technology that emerged in the 1990s can realize the integration of sampling, separation, detection and other experimental procedures and biochemical reactions on a tiny chip, thereby reducing sample consumption, improving detection sensitivity, shortening reaction time, and realizing Automation of the testing process and informatization of the testing results. The advantages of the above-mentioned microfluidic chi...

AI Technical Summary

Problems solved by technology

In the field of scientific research, for hard plastic, polymer or glass chips, it is often used to enter the fluid by sticking the catheter to the fluid inlet and outlet of the chip, which can only be used once and is irreversible. Risk; for soft polydimethylsiloxane (PDMS) chips, the method of directly inserting the sample hole of the chip into a hard catheter is often used to enter the liquid, which is cumbersome to operate, and the PDMS powder at the sample port is easy to enter the flow path, making it Blockage, and repeated plugging and unplugging of the pipeline will damage the soft chip interface

The accuracy of the above method is poor, it is not easy to withstand high liquid inlet pressure and liquid inlet speed, and it is easy to leak liquid

[0004] In the field of engineering products, the existing fixture design mostly uses bolts to connect the upper and lower cover plates to provide pressure to seal the interface. Although the sealing effect is good, the structure is complicated and disassembly is cumbersome, and additional tools are required.

In addition, most of the fixtures are designed and manufactured in an integrated manner, with fixed dimensions, and can only be applied to microfluidic chips of the same specification.

And every time the chip is replaced, the flow path of the fixture must be carefully cleaned to avoid contamination of the new chip, which greatly limits the application and popularization of this kind of fixture in microfluidic chips.

Especially for the microfluidic chip designed and applied for POCT, the chip system requires a simple structure and can be operated by non-professionals without tools. The current fixture design cannot meet this requirement

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