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Biocompatible hemostatic material with wound healing function and preparation method thereof

A technology for biocompatibility and wound repair, which is applied in the field of biocompatible hemostatic materials and its preparation, can solve the problems of affecting wound repair, not promoting wound repair, wound softening, etc., to reduce labor and time costs and process less , High biocompatibility effect

Inactive Publication Date: 2017-11-10
THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, although the starch-based hemostatic material can achieve hemostatic effect, it does not promote wound repair, and even because the hemostatic material adheres to the wound surface, it will cause the wound to soften and affect the wound repair.

Method used

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  • Biocompatible hemostatic material with wound healing function and preparation method thereof

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Embodiment 1

[0024] The preparation of embodiment 1 starch-based nanoparticles

[0025] Raw materials (parts by weight): potato starch, 50 parts; chondroitin sulfate, 15 parts; glutamine, 10 parts; sodium trimetaphosphate, 20 parts; genipin, 20 parts. As the starch, cornstarch can also be used.

[0026] The preparation method comprises the steps of:

[0027] Step S1, gelatinization: Weigh potato starch and add it into distilled water, stir at 50°C to obtain a uniform and transparent starch solution, and let it stand for use; wherein, the mass concentration of potato starch in the starch solution is 15%;

[0028] Step S2, cross-linking: Add chondroitin sulfate, glutamine, sodium trimetaphosphate and genipin to the above starch solution, dissolve and stir evenly, adjust the pH value to 8.5 with sodium hydroxide, and then raise the temperature to 50°C Constant temperature reaction for 3 hours;

[0029] Step S3, granulation: adjust the above solution to neutral with hydrochloric acid, let s...

Embodiment 2

[0031] The preparation of embodiment 2 starch-based nanoparticles

[0032] Raw materials (parts by weight): potato starch, 40 parts; chondroitin sulfate, 10 parts; glutamine, 8 parts; sodium trimetaphosphate, 15 parts; genipin, 15 parts. As the starch, cornstarch can also be used.

[0033] The preparation method comprises the steps of:

[0034] Step S1, gelatinization: Weigh potato starch and add it into distilled water, stir at 50°C to obtain a uniform and transparent starch solution, and let it stand for use; wherein, the mass concentration of potato starch in the starch solution is 10%;

[0035] Step S2, cross-linking: Add chondroitin sulfate, glutamine, sodium trimetaphosphate and genipin to the above starch solution, dissolve and stir evenly, adjust the pH value to 7.5 with sodium hydroxide, and then raise the temperature to 45°C Constant temperature reaction for 4 hours;

[0036] Step S3, granulation: adjust the above solution to neutral with hydrochloric acid, let st...

Embodiment 3

[0038] The preparation of embodiment 3 starch-based nanoparticles

[0039] Raw materials (parts by weight): potato starch, 60 parts; chondroitin sulfate, 20 parts; glutamine, 12 parts; sodium trimetaphosphate, 25 parts; genipin, 25 parts. As the starch, cornstarch can also be used.

[0040] The preparation method comprises the steps of:

[0041] Step S1, gelatinization: Weigh potato starch and add it into distilled water, stir at 50°C to obtain a uniform and transparent starch solution, and let it stand for use; wherein, the mass concentration of potato starch in the starch solution is 20%;

[0042] Step S2, cross-linking: Add chondroitin sulfate, glutamine, sodium trimetaphosphate and genipin to the above starch solution, dissolve and stir evenly, adjust the pH value to 9.5 with sodium hydroxide, and then raise the temperature to 55°C Constant temperature reaction for 2 hours;

[0043] Step S3, granulation: adjust the above solution to neutral with hydrochloric acid, let s...

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Abstract

The invention discloses a biocompatible hemostatic material with a wound healing function and a preparation method thereof, the biocompatible hemostatic material is a starch-based nano particle, is prepared from starch, chondroitin sulfate and glutamine by crosslinking with sodium trimetaphosphate and genipin, and the biocompatible hemostatic material comprises 40-60 parts by weight of the starch, 10-20 parts by weight of the chondroitin sulfate, 8-12 parts by weight of the glutamine, 15-25 parts by weight of the sodium trimetaphosphate and 15-25 parts by weight of the genipin. The starch-based nano particle has high biocompatibility, good wound healing effect and hemostatic effect, can be used as the hemostatic material, has hemostatic, biodegradable, biocompatible and wound repair effects; the invention of rice starch, the preparation process of the starch-based nano particle is simple and less in process, and can significantly reduce the cost of labor and time in the production.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a biocompatible hemostatic material with wound repairing effect and a preparation method thereof. Background technique [0002] Generally, surgical operations and trauma will form bloody wounds, and a large amount of blood will be lost during the period. Good hemostasis technology is the key to ensure the success of the operation. Mechanical hemostasis on the wounds of solid organs with rich blood flow and high fragility, such as the brain, liver, kidney, and spleen, can easily cause tissue damage, bleeding from needle holes or gap bleeding, and even affect the function of the organs in severe cases. [0003] In this regard, domestic and foreign efforts have been devoted to the development of hemostatic materials that can quickly stop bleeding on parenchymal organ wounds, have little impact on their functions, and have good biocompatibility. At present, blood fact...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/02A61L24/00
CPCA61L24/0015A61L24/0042A61L24/02A61L24/08A61L2300/412A61L2300/624A61L2400/04A61L2400/12C08L3/02C08L5/08
Inventor 王严胡骏稀樊星
Owner THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV