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Paclitaxel wine and method for preparing paclitaxel wine

A paclitaxel and liquor technology, applied in the field of health care, can solve the problems of unclear synthesis route, obvious adverse reactions of patients, large toxic and side effects, etc., and achieve the effects of reducing the probability of cancer occurrence, improving the immune function of the human body, and improving the immune function of the human body.

Inactive Publication Date: 2017-11-10
郭正昊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The drugs commonly used in modern clinics to treat cancer are etoposide, cisplatin, vinblastine, etc., but these drugs have relatively large toxic and side effects, and the adverse reactions of patients after taking them are obvious.
Paclitaxel is known as the "third-generation antineoplastic drug", but because its synthetic route is not clear, it can only be extracted from Taxus chinensis. Therefore, its yield and related standards cannot meet the standards of therapeutic drugs, and the amount cannot be widely used. Clinical, and thus cannot be widely used in the treatment of cancer

Method used

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  • Paclitaxel wine and method for preparing paclitaxel wine
  • Paclitaxel wine and method for preparing paclitaxel wine
  • Paclitaxel wine and method for preparing paclitaxel wine

Examples

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Comparison scheme
Effect test

Embodiment 1

[0061] The paclitaxel wine provided in this example is fermented from a variety of raw materials, including 1500Kg white wine, 2Kg paclitaxel extract, 30Kg jujube extract and 10Kg medlar extract.

[0062] The method for preparing this paclitaxel wine is as follows:

[0063] First, 100Kg of yew was pulverized and mixed with 200Kg of ethyl acetate-acetone solvent. Turn on the microwave extractor, set the extraction for 10 minutes, and set the temperature to 45°C. At this time, 100Kg of ethyl acetate and 100Kg of acetone are included in the ethyl acetate-acetone solvent. After the extraction was completed, the crude extract was obtained by filtration. The crude extract is 0.7m 3 The flow rate per hour passes through a hollow fiber ultrafiltration membrane composed of PVDF membrane, and then passes through high-speed countercurrent chromatography to obtain paclitaxel extract. Among them, the solvent used in high-speed countercurrent chromatography is n-hexane-ethyl acetate-eth...

Embodiment 2

[0068] The paclitaxel wine provided in this example is fermented from a variety of raw materials, including 1000Kg white wine, 3Kg paclitaxel extract, 40Kg jujube extract, 15Kg medlar extract and 20Kg collagen extract.

[0069] The method for preparing paclitaxel wine provided in this example is consistent with Example 1, only the operating conditions and relative ratios are changed. The yew used is 120Kg, the volume ratio of ethyl acetate to acetone in the ethyl acetate-acetone solvent is 1:1.2, and the flow rate used is 0.8m 3 / h, the volume ratio among n-hexane, ethyl acetate, ethanol and water is 1:1:1.2:1.3.

[0070] When extracting the jujube extract, the jujube raw material used was 73Kg, the water temperature was 65°C, the consumption of water was 511Kg, and the extraction was performed for 2 hours. The consumption of 70% ethanol is 329Kg, and temperature is 65 ℃. The consumption of 99% ethanol is 329Kg, and the temperature is 65°C. The concentration factor is 6 tim...

Embodiment 3

[0074] The paclitaxel wine provided in this example is fermented from a variety of raw materials, including 2000Kg white wine, 5Kg paclitaxel extract, 50Kg jujube extract, 20Kg medlar extract and 30Kg collagen extract.

[0075] The method for preparing paclitaxel wine provided in this example is consistent with Example 1, only the operating conditions and relative ratios are changed. The yew used is 280Kg, the volume ratio of ethyl acetate to acetone in the ethyl acetate-acetone solvent is 1:1.1, and the flow rate used is 0.7m 3 / h, the volume ratio among n-hexane, ethyl acetate, ethanol and water is 7:4:3:6.

[0076] When extracting the jujube extract, the used jujube raw material is 60Kg, the water temperature is 75° C., the water consumption is 9 times of the jujube raw material, and the extraction is performed for 2 hours. The consumption of 75% ethanol is 6 times of jujube raw material, and temperature is 65 ℃. The consumption of 98% ethanol is 540Kg, and temperature is...

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Abstract

The invention discloses paclitaxel wine and a method for preparing the paclitaxel wine. The paclitaxel wine is prepared by fermenting a variety of raw materials, wherein the raw materials comprise 1000-2000 parts of baijiu, 2-6 parts of paclitaxel extracting solution, 30-50 parts of fructus jujubae extracting solution, and 10-20 parts of Chinese wolfberry fruit extracting solution. Paclitaxel, the Chinese wolfberry fruit extracting solution and the fructus jujubae extracting solution are dissolved in alcohol together, a synergistic effect is generated after the wine is taken by the human body, then uterus cancer and breast cancer are prevented by the synergistic function, and the occurrence probability of cancer is reduced. Meanwhile, by adding the Chinese wolfberry fruit extracting solution and the fructus jujubae extracting solution, the mouthfeel of the health wine can be improved, the efficacy in improving the immune function of the human body of the health wine is promoted, and the efficacies of maintaining beauty and keeping young are achieved.

Description

technical field [0001] The invention relates to the field of health care, and in particular to a paclitaxel wine and a method for preparing the paclitaxel wine. Background technique [0002] In medicine, cancer refers to malignant tumors originating from epithelial tissue, which is the most common type of malignant tumors. Generally speaking, "cancer" generally refers to all malignant tumors. Tumor is a new organism formed by the body under the action of various tumorigenic factors, and the cells of local tissues lose their normal regulation of their growth at the gene level, resulting in abnormal proliferation and differentiation. Once a new organism is formed, it does not stop growing due to the elimination of the cause. Its growth is not regulated by normal body physiology, but destroys normal tissues and organs. This is especially obvious in malignant tumors. [0003] The drugs commonly used in modern clinics for treating cancer are etoposide, cisplatin, vinblastine, e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12G3/04A61K36/815A61P35/00A61P37/02
CPCA61K31/337A61K36/725A61K36/815C12G3/04A61K2300/00
Inventor 田大伟
Owner 郭正昊
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