Preparation method of collagen stanch fiber

A technology of hemostatic fiber and collagen, which is applied in medical science, surgery, surgical adhesives, etc., can solve the problems of long hemostasis time, low adhesion of hemostatic materials and wound surface, poor hemostatic effect, etc. Immunogenicity, Ease of Handling Effects

Inactive Publication Date: 2017-11-17
无锡贝迪生物工程股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The technical problem to be solved by the present invention is to overcome the defects of the existing hemostatic materials such as low adhesion to the wound surface, long hemostatic time and poor hemostatic effect, and to provide a preparation method of collagen hemostatic fiber

Method used

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  • Preparation method of collagen stanch fiber
  • Preparation method of collagen stanch fiber
  • Preparation method of collagen stanch fiber

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A preparation method of collagen hemostatic fiber is as follows:

[0039] S1: Take the back of the whole calfskin, use a shaving machine to remove the hair on the back of the calfskin, then use a blade to scrape off the fat layer and fluff layer on the cowhide, cut it into small pieces of about 1 to 2 cm, and place it in- Freeze at 50°C, then cut the frozen cowhide into slices with a thickness of about 0.2mm and a size of 1cm with a slicer;

[0040] S2: Degreasing treatment: Soak the skin slices in 2% sodium chloride solution, place on a magnetic stirrer and stir slowly for 24 hours, replace the soaking solution after 5-7 hours; then soak the skin slices in 1% sodium carbonate solution, Place it on a magnetic stirrer and stir slowly for 24 hours, and replace the soaking solution after 5-7 hours; finally transfer the skin slices to a lipolysis solution with 1% weight of the skin slices, place it on a magnetic stirrer and stir slowly for 24 hours, and the reaction pH is 9...

Embodiment 2

[0047] A preparation method of collagen hemostatic fiber is as follows:

[0048] S1: Take the back of the whole calfskin, use a shaving machine to remove the hair on the back of the calfskin, then use a blade to scrape off the fat layer and fluff layer on the cowhide, cut it into small pieces of about 1 to 2 cm, and place it in- Freeze at 50°C, and then cut the frozen cowhide into slices with a thickness of about 0.3mm and a size of 0.5cm with a slicer;

[0049] S2: Degreasing treatment: Soak the skin slices in 5% sodium chloride solution, place on a magnetic stirrer and stir slowly for 24 hours, replace the soaking solution after 5-7 hours; then soak the skin slices in 2% sodium carbonate solution, Put it on a magnetic stirrer and stir slowly for 24 hours, and replace the soaking solution after 5-7 hours; finally transfer the skin slices to a lipolysis solution with 2% weight of the skin slices, place it on a magnetic stirrer and stir slowly for 24 hours, and the reaction pH ...

Embodiment 3

[0055] A preparation method of collagen hemostatic fiber is as follows:

[0056] S1: Take the back of the whole calfskin, use a shaving machine to remove the long hair on the back of the calfskin, then use a blade to scrape off the fat layer on the calfskin, and then use Na 2 SO 4 :Na 2 S:CaCl 2 = 1:50:20 hair removal agent for hair removal for 15 minutes, after cleaning, cut into small pieces of about 1-2cm, freeze at -50°C, and then cut the frozen cowhide pieces with a slicer to a thickness of about 0.4mm and a size of 2cm the skin;

[0057] S2: Degreasing treatment: Soak the skin slices in 8% sodium chloride solution, place on a magnetic stirrer and stir slowly for 24 hours, replace the soaking solution after 5-7 hours; then soak the skin slices in 3% sodium carbonate solution, Put it on a magnetic stirrer and stir slowly for 24 hours, and replace the soaking solution after 5-7 hours; finally transfer the skin slices to a lipolysis solution with 3% weight of the skin sl...

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Abstract

The invention discloses a preparation method of collagen stanch fiber. The preparation method comprises following steps: S1, buttermilk skin is treated so as to obtain smashed buttermilk skin; S2, degreasing is carried out; S3, ethanol gradient dehydration is carried out; S4, smashing is carried out; S5, sieving is carried out; and S6, drying and crosslinking are carried out so as to obtain the collagen stanch fiber. The collagen stanch fiber is subjected to irradiation disinfection so as to obtain a non-water-soluble local hemostatic. The collagen stanch fiber possesses high biocompatibility and low immunogenicity, and excellent mechanical strength; dissolving with water or acid is not caused; swelling into gel is not caused; wound adhesiveness is excellent; hemostatic effect on irregular wounds is excellent; the finished product is short fiber, and shapes like cotton balls; scattering is not easily caused in applications; operation is convenient; the collagen stanch fiber possesses high hydrophilic performance; liquid absorption amount is as high as 16 times; absorption of blood or seepage can be realized quickly; the collagen stanch fiber is capable of sealing wounds, promoting formation of thrombus from blood platelet, and realizing rapid and long-lasting hemostatic effect.

Description

technical field [0001] The invention relates to a collagen hemostatic fiber and a preparation method thereof. The prepared collagen hemostatic fiber has strong hydrophilicity, can quickly absorb blood or exudate, adhere to the wound surface, is not easy to fall off under pressure, can promote the adhesion of platelets to form thrombus, and then quickly and long-term hemostasis. Background technique [0002] Biomedical materials are a class of high-tech new materials developed in the past 30 years. Among them, absorbable hemostatic materials have gradually attracted the attention of the medical community with the increase in traffic accidents, major disasters and other accidents. With the rapid development of modern science and technology, the research of various hemostatic materials has made very fast progress, and various new biological hemostatic materials are constantly emerging, and their performance is getting better and better. Currently commonly used hemostatic mater...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00
Inventor 陆金婷程咏梅任伟业
Owner 无锡贝迪生物工程股份有限公司
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