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High-intensity protein aquagel and preparation method thereof

A protein and hydrogel technology, which is applied in the field of high-strength protein hydrogel and its preparation, can solve the problems of limiting the application range of protein hydrogel, incompatibility between strength and toughness, complex steps, etc., and achieves short preparation time , The production process is simple and easy, and the effect of high control precision

Inactive Publication Date: 2017-11-24
HENAN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although some progress has been made in improving the mechanical properties of natural protein hydrogels, most of the reported protein hydrogels have insufficient strength and toughness or require complex steps and high costs to synthesize recombinant proteins, which limit The scope of application of protein hydrogel

Method used

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  • High-intensity protein aquagel and preparation method thereof
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  • High-intensity protein aquagel and preparation method thereof

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Experimental program
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Embodiment 1

[0026] Such as figure 1 , 2 As shown in and 3, a high-strength protein hydrogel is composed of the following substances in parts by mass: soybean protein isolate 15%, N-(hydroxymethyl)acrylamide 60%, 2-oxoglutaric acid 0.3% , polyethylene glycol diacrylate 10%, and the balance is deionized water.

[0027]A method for preparing a high-strength protein hydrogel, comprising the following steps:

[0028] In the first step, mixing materials, first add deionized water into the reactor, and then sequentially add the protein used to form the first network of the double network gel, and to polymerize the second network of the double network hydrogel Add monomers, initiators, and cross-linking agents to deionized water, stir at a uniform speed in one direction for 15 minutes through a stirring device, and then leave to stand to prepare a clear mixed solution, wherein the stirring speed is 600 rpm;

[0029] In the second step, the reactor is prefabricated, and the air in the reactor i...

Embodiment 2

[0033] A high-strength protein hydrogel, which is composed of the following substances in parts by mass: the protein in the first network is 20% bovine serum albumin, 45% acrylamide, 0.5% 2,2-diethoxyacetophenone, N, N'-methylenebisacrylamide 11%, the balance is deionized water.

[0034] A method for preparing a high-strength protein hydrogel, comprising the following steps:

[0035] In the first step, mixing materials, first add deionized water into the reactor, and then sequentially add the protein used to form the first network of the double network gel, and to polymerize the second network of the double network hydrogel The monomer, initiator, and crosslinking agent are added to deionized water, stirred at a uniform speed in one direction by a stirring device for 10 minutes, and then left to stand to prepare a clear mixed solution, wherein the stirring speed is 500 rpm;

[0036] In the second step, the reactor is prefabricated, and the air in the reactor is discharged thr...

Embodiment 3

[0040] Such as figure 1 and 2 As shown, a high-strength protein hydrogel is composed of the following substances in parts by mass: ovalbumin 2%, N-(2-hydroxyethyl)acrylamide, stearyl methacrylate 55%, 1-hydroxy 0.3% cyclohexylpropiophenone, 10-14% ethylene glycol dimethacrylate, and the balance is deionized water.

[0041] A method for preparing a high-strength protein hydrogel, comprising the following steps:

[0042] In the first step, mixing materials, first add deionized water into the reactor, and then sequentially add the protein used to form the first network of the double network gel, and to polymerize the second network of the double network hydrogel Add monomers, initiators, and cross-linking agents to deionized water, stir at a uniform speed in one direction for 30 minutes through a stirring device, and then leave to stand to prepare a clear mixed solution, wherein the stirring speed is 800 rpm;

[0043] In the second step, the reactor is prefabricated, and the a...

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Abstract

The invention relates to high-intensity protein aquagel, which is prepared from the following substances in parts by weight: 5 to 21 percent of protein used for forming a first network of double-network gel, 45 to 60 percent of monomers used for forming a second network of double-network gel through polymerization, 0.1 to 0.6 percent of initiators, 10 to 14 percent of cross-linking agents and the balance deionized water. A preparation method of the aquagel comprises four steps including material mixing, reaction kettle prefabrication, primary reaction and initiation reaction. On one hand, the production process is simple; the implementation is easy; the time consumption of the preparation process is short; the energy consumption is low; the raw materials are simple; the obtaining is easy; the preparation process is green and safe; on the other hand, the control precision of the process parameters of the production environment is high; the prepared protein aquagel has the characteristics of high intensity and high toughness; the stretch intensity is 0.5 MPa; the stretch modulus is 60 to 800 KPa; the stretch stress reaches 1000 to 4800 percent.

Description

technical field [0001] The invention relates to a high-strength protein hydrogel and a preparation method thereof, belonging to the technical field of hydrogel materials. Background technique [0002] Hydrogel is a material containing a large amount of water with a three-dimensional network structure formed by a certain cross-linking method. According to the source of raw materials, it can be divided into natural polymer hydrogel and synthetic polymer hydrogel, and the hydrogel prepared by combining the two is a hybrid hydrogel. Natural polymer hydrogels can be prepared from natural polysaccharides and their derivatives, natural proteins, DNA, nucleic acids and polypeptides. Among them, natural protein hydrogels are not only rich in sources, but also have excellent biocompatibility and abundant reactive groups, so they have broad development and application prospects in the fields of tissue engineering, drug release, regenerative medicine, and micromanufacturing. . [000...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08J3/28C08F291/12C08F220/54C08F220/56C08F220/58C08F220/18C08F220/20C08L51/00C08L51/08
CPCC08F283/065C08F289/00C08J3/075C08J3/28C08J2451/08C08J2351/00C08F220/58C08F220/1818
Inventor 陈强朱琳杨佳唐自清陈峰
Owner HENAN POLYTECHNIC UNIV