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Filtering medium for selectively filtering out leucocytes and platelets, and preparation method thereof

A filter medium and platelet technology, which is applied in the field of white blood cell filtration, can solve the problems of red blood cell adsorption and reduce electrostatic repulsion, and achieve the effect of improving interception, improving use safety, and not affecting integrity

Active Publication Date: 2017-12-05
广州达济医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this invention still has certain deficiencies: since red blood cells, white blood cells, and platelets are also negatively charged, by reducing the electrostatic repulsion between the filter material and negatively charged blood cells, a certain amount of red blood cell adsorption may also be produced.

Method used

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  • Filtering medium for selectively filtering out leucocytes and platelets, and preparation method thereof
  • Filtering medium for selectively filtering out leucocytes and platelets, and preparation method thereof
  • Filtering medium for selectively filtering out leucocytes and platelets, and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0035] The preparation of embodiment 1 filter substrate

[0036] (1) Dissolve polysulfone in dichloromethane to make a 2% (w / v) solution, add 2% (v / v) chloromethyl ether to the system, heat and react in a water bath at 35°C for 12 hours, and after the reaction, Place the product in absolute ethanol for precipitation, wash with ethanol for several times, and then wash with deionized water for several times to ensure that the chloride ions have been completely removed, filter, and dry the product in an oven at 60°C for 24 hours. Transfer to a vacuum drying oven and dry at room temperature for 12 hours to obtain chloromethylated polysulfone;

[0037] (2) Add 1.5 times the weight of the reaction solution to the chloromethylated polysulfone, and the reaction solution is mixed with phthalimide and sodium hydride at a mass ratio of 1:0.15 to form a concentration of 4%. (w / v) aqueous solution, heated to reflux for 6 hours, cooled, precipitated the product with methanol, washed it rep...

Embodiment 2

[0039] The preparation of embodiment 2 cellulose acetate particles

[0040] Take cellulose acetate and add deionized water to make a suspension with a mass concentration of 4% (m / v), add polyamide polyamine epichlorohydrin, the cellulose acetate and polyamide polyamine epichlorohydrin The mass ratio is 1:0.3; ultrasonic treatment for 30min, then sealed in a high-pressure steam boiler, treated at 180°C for 6h, cooled to room temperature, centrifuged to collect the precipitate, washed 3 times with deionized water, and vacuum-dried at 80°C for 6h , that is, cellulose acetate particles coated with polyamide polyamine epichlorohydrin on the surface.

Embodiment 3

[0041] The preparation of embodiment 3 cellulose acetate particles

[0042] Take cellulose acetate and add deionized water to make a suspension with a mass concentration of 2% (m / v), add polyamide polyamine epichlorohydrin, the cellulose acetate and polyamide polyamine epichlorohydrin The mass ratio is 1:0.24; ultrasonic treatment for 20min, then sealed in a high-pressure steam boiler, treated at 180°C for 4h, cooled to room temperature, centrifuged to collect the precipitate, washed 3 times with deionized water, and vacuum-dried at 80°C for 6h , that is, cellulose acetate particles coated with polyamide polyamine epichlorohydrin on the surface.

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Abstract

The invention relates to a filtering medium for selectively filtering out leucocytes and platelets, and a preparation method thereof. The filtering medium comprises a filtering substrate and a grafting material grafted on the filtering substrate, the filtering substrate is a modified polysulfone fiber film, and the grafting material is cellulose acetate particles with the surface being coated with polyamide polyamine epichlorohydrin. The filtering medium has a good filtering effect on the leucocytes and platelets, has no interception effect on erythrocytes, has no influences on the integrity of blood components, and greatly improves the use safety and the use reliability. The filtering medium does not cause any elution problem, and can avoid the pollution of eluate.

Description

technical field [0001] The invention belongs to the technical field of leukocyte filtration, and in particular relates to a filter medium for selectively filtering out leukocytes and platelets and a preparation method thereof. Background technique [0002] Removing white blood cells from the blood to reduce the risk of blood transfusion is the original intention of people developing white blood cell filters in the past. The principle of the leukocyte filter is to use the principle of mechanical blockage and adsorption to intercept leukocytes, and let the red blood cells with smooth surface and strong deformability pass through. At present, the requirement of the third-generation leukocyte filter is to achieve a 4log filtration rate (that is, the leukocyte filtration rate reaches 99.99%), which is also the quality standard proposed by developed countries for the leukocyte filter. [0003] However, with the development of basic medicine, it has been found that the source of a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/68B01D67/00
CPCB01D67/0002B01D71/16B01D71/68
Inventor 王衡东
Owner 广州达济医学科技有限公司
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